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A0LSX9 (UPPP_ACIC1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Acel_0766
OrganismAcidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]
Taxonomic identifier351607 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290675

Regions

Transmembrane42 – 6221Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane253 – 27321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A0LSX9 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 20521CCB03EF892C

FASTA27629,501
        10         20         30         40         50         60 
MNGVSAVVLG VIEGVTEFLP VSSTAHLTIA EALMGMKTDA PAVTAFTAVI QMGAILAAIV 

        70         80         90        100        110        120 
YFRRDIRTVV TAWFRGLVRA DERRSPDALL GWYVIAGTIP IGLAGYLGRN VIKHDLRSLW 

       130        140        150        160        170        180 
YVVAGLVLWS IAIVYAERTA AQRRDLRDMR LPDAVFIGVI QVLALVPGVS RSGATISAGL 

       190        200        210        220        230        240 
RQGFDRVAAT RFSFLLAIPA LLAAGIFELK DAVGTSGVSM ASLVVGTGMA FLTAYASIAW 

       250        260        270 
LLRFVAHHSL TNFVWYRVTV AVFVVAALTT GLVHAV 

« Hide

References

[1]"Complete sequence of Acidothermus cellulolyticus 11B."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000481 Genomic DNA. Translation: ABK52539.1.
RefSeqYP_872525.1. NC_008578.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING351607.Acel_0766.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK52539; ABK52539; Acel_0766.
GeneID4485302.
KEGGace:Acel_0766.
PATRIC20671934. VBIAciCel132453_0809.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAMGASKRS.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycACEL351607:GIXW-783-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_ACIC1
AccessionPrimary (citable) accession number: A0LSX9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: December 12, 2006
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families