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A0LSX9

- UPPP_ACIC1

UniProt

A0LSX9 - UPPP_ACIC1

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciACEL351607:GIXW-783-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Acel_0766
    OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
    Taxonomic identifieri351607 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus
    ProteomesiUP000008221: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Undecaprenyl-diphosphatasePRO_0000290675Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351607.Acel_0766.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221HelicalUniRule annotationAdd
    BLAST
    Transmembranei88 – 10821HelicalUniRule annotationAdd
    BLAST
    Transmembranei116 – 13621HelicalUniRule annotationAdd
    BLAST
    Transmembranei149 – 16921HelicalUniRule annotationAdd
    BLAST
    Transmembranei187 – 20721HelicalUniRule annotationAdd
    BLAST
    Transmembranei222 – 24221HelicalUniRule annotationAdd
    BLAST
    Transmembranei253 – 27321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiLHIILAC.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0LSX9-1 [UniParc]FASTAAdd to Basket

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    MNGVSAVVLG VIEGVTEFLP VSSTAHLTIA EALMGMKTDA PAVTAFTAVI    50
    QMGAILAAIV YFRRDIRTVV TAWFRGLVRA DERRSPDALL GWYVIAGTIP 100
    IGLAGYLGRN VIKHDLRSLW YVVAGLVLWS IAIVYAERTA AQRRDLRDMR 150
    LPDAVFIGVI QVLALVPGVS RSGATISAGL RQGFDRVAAT RFSFLLAIPA 200
    LLAAGIFELK DAVGTSGVSM ASLVVGTGMA FLTAYASIAW LLRFVAHHSL 250
    TNFVWYRVTV AVFVVAALTT GLVHAV 276
    Length:276
    Mass (Da):29,501
    Last modified:December 12, 2006 - v1
    Checksum:i20521CCB03EF892C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000481 Genomic DNA. Translation: ABK52539.1.
    RefSeqiYP_872525.1. NC_008578.1.

    Genome annotation databases

    EnsemblBacteriaiABK52539; ABK52539; Acel_0766.
    GeneIDi4485302.
    KEGGiace:Acel_0766.
    PATRICi20671934. VBIAciCel132453_0809.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000481 Genomic DNA. Translation: ABK52539.1 .
    RefSeqi YP_872525.1. NC_008578.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351607.Acel_0766.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK52539 ; ABK52539 ; Acel_0766 .
    GeneIDi 4485302.
    KEGGi ace:Acel_0766.
    PATRICi 20671934. VBIAciCel132453_0809.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi LHIILAC.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci ACEL351607:GIXW-783-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43068 / 11B.

    Entry informationi

    Entry nameiUPPP_ACIC1
    AccessioniPrimary (citable) accession number: A0LSX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3