Skip Header

Contribute Send feedback
Read comments (?) or add your own

A0LSX2 (A0LSX2_ACIC1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Glutamate 5-kinase HAMAP MF_00456
EC=2.7.2.11 HAMAP MF_00456
Alternative name(s):
Gamma-glutamyl kinase HAMAP MF_00456
Gene names
Name:proB HAMAP MF_00456
Ordered Locus Names:Acel_0759
OrganismAcidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]
Taxonomic identifier351607 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline By similarity. HAMAP MF_00456 SAAS SAAS011529

Catalytic activity

ATP + L-glutamate = ADP + L-glutamate 5-phosphate. HAMAP MF_00456 SAAS SAAS011529

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. HAMAP MF_00456 SAAS SAAS011529

Subcellular location

Cytoplasm By similarity HAMAP MF_00456 SAAS SAAS011529.

Sequence similarities

Belongs to the glutamate 5-kinase family. HAMAP MF_00456

Contains 1 PUA domain. HAMAP MF_00456 SAAS SAAS011529

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain296 – 37479PUA By similarity HAMAP MF_00456

Sequences

Sequence LengthMass (Da)Tools
A0LSX2 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 8A69C4310B0B95F4

FASTA39341,332
        10         20         30         40         50         60 
MSGTRPEVTA AQTIVVKIGS SSVTSYPAAR AGSAAADDQP GGSASGLREE NIAALAAAVA 

        70         80         90        100        110        120 
ERVSRGAHCV IVSSGAIAAG LGPLGLVSRP RDLATQQAAA SVGQSLLVRA YARAFAVHRI 

       130        140        150        160        170        180 
TVGQILLTSD DMIRRAHYRN AERTLRRLFE LGVVPIVNEN DTVVTDEIRF GDNDRLAALV 

       190        200        210        220        230        240 
AHLIRADLLV LLSDVDALYT APPNRPGARR IEVVSSERDL DAIDLGGVGT AVGTGGMITK 

       250        260        270        280        290        300 
IEAARLATSA GIPVVLTAAT AVAAALRGDD VGTFFRPTGR RMSSRLLWLA HATAPRGRLV 

       310        320        330        340        350        360 
LDAGAVAAVV DRRLSLLPAG VVGVHGDFNA GDPVDLVDEH GRRVARGLVN YDAADLPNLI 

       370        380        390 
GRSTWELAQQ FGPDYQREVV HRDDLVVLVR RSR

« Hide

References

[1]"Complete sequence of Acidothermus cellulolyticus 11B."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000481 Genomic DNA. Translation: ABK52532.1.
RefSeqYP_872518.1. NC_008578.1.

3D structure databases

ProteinModelPortalA0LSX2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0LSX2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4486676.
GenomeReviewsGene locus Acel_0759 in contig CP000481_GR.
KEGGace:Acel_0759.
PATRIC20671918. VBIAciCel132453_0802.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0263.
HOGENOMHBG507643.
OMATFGDNDM.
PhylomeDBA0LSX2.
ProtClustDBPRK05429.

Family and domain databases

HAMAPMF_00456. ProB.
[Tree]
InterProIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view]
Gene3DG3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KOK00931.
PfamPF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view]
PIRSFPIRSF000729. GK. 1 hit.
PRINTSPR00474. GLU5KINASE.
SMARTSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMSSF53633. Aa_kinase. 1 hit.
SSF88697. PUA-like. 1 hit.
TIGRFAMsTIGR01027. ProB. 1 hit.
PROSITEPS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0LSX2_ACIC1
AccessionPrimary (citable) accession number: A0LSX2
Entry history
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info