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Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 38C4-typeUniRule annotationAdd BLAST26
Nucleotide bindingi121 – 128ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
Gene namesi
Name:clpXUniRule annotation
Ordered Locus Names:Acel_0739
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaAcidothermalesAcidothermaceaeAcidothermus
Proteomesi
  • UP000008221 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000245071 – 427ATP-dependent Clp protease ATP-binding subunit ClpXAdd BLAST427

Proteomic databases

PRIDEiA0LSV2.

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi351607.Acel_0739.

Structurei

3D structure databases

ProteinModelPortaliA0LSV2.
SMRiA0LSV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 38C4-typeUniRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4105CHN. Bacteria.
COG1219. LUCA.
HOGENOMiHOG000010093.
KOiK03544.
OMAiDIMYDLP.
OrthoDBiPOG091H01U4.

Family and domain databases

HAMAPiMF_00175. ClpX. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
PANTHERiPTHR11262. PTHR11262. 2 hits.
PfamiView protein in Pfam
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00382. clpX. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LSV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLGDGGDL LKCSFCGKSQ KQVKKLIAGP GVYICDECID LCNEIIEEEL
60 70 80 90 100
SESHEPKFDQ LPKPREICEF LDQYVIGQET AKKALSVAVY NHYKRIQVGG
110 120 130 140 150
SSRSSNDSVE LAKSNILLIG PTGCGKTYLA QTLARMLNVP FAIADATALT
160 170 180 190 200
EAGYVGEDVE NILLKLIQAA DYDVKRAETG IIYIDEIDKI ARKSENPSIT
210 220 230 240 250
RDVSGEGVQQ ALLKILEGTT ASVPPQGGRK HPHQEFIQID TTNILFIVGG
260 270 280 290 300
AFAGLEKIIE ARIGKKGIGF TATLHGKRDL NTADIFSHVM PEDLLKYGMI
310 320 330 340 350
PEFVGRLPVI TTVTSLDREA LIRILTEPKN ALVRQYQRLF ELDSVDLEFT
360 370 380 390 400
DDALEAIADQ AILRGTGARG LRAIMEEVLL SVMYDIPSRT DVARVVITRD
410 420
VVLNNVNPTL VPRDSVVAKR ERREKTA
Length:427
Mass (Da):46,980
Last modified:December 12, 2006 - v1
Checksum:iED443C28D36CB11C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK52512.1.
RefSeqiWP_011719575.1. NC_008578.1.

Genome annotation databases

EnsemblBacteriaiABK52512; ABK52512; Acel_0739.
KEGGiace:Acel_0739.

Similar proteinsi

Entry informationi

Entry nameiCLPX_ACIC1
AccessioniPrimary (citable) accession number: A0LSV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: October 25, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families