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A0LSR8 (ILVD_ACIC1) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase
Short name=DAD
EC=4.2.1.9
Gene names
Name:ilvD
Ordered Locus Names:Acel_0705
OrganismAcidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]
Taxonomic identifier351607 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012

Cofactor

Binds 1 4Fe-4S cluster Potential.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012

Sequence similarities

Belongs to the IlvD/Edd family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558Dihydroxy-acid dehydratase HAMAP MF_00012
PRO_0000321588

Sites

Metal binding1271Iron-sulfur (4Fe-4S) Potential
Metal binding1991Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
A0LSR8 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 25A6D7FBC485AC2C

FASTA55858,600
        10         20         30         40         50         60 
MRAQPDLKPR SRDVTDGLER AAARGMLRAV GMTDADWEKP QIGVASSWNE ITPCNLSLDR 

        70         80         90        100        110        120 
LAQAAKEGVH AAGGYPLEFA TISVSDGISM GHEGMHFSLI SREVIADSVE TVFMAERFDG 

       130        140        150        160        170        180 
AVLLAGCDKS EPGMLMAAAR LDLAAVFLYA GSTLPGKLGD RDINIVDAFE AVGGCLRGLV 

       190        200        210        220        230        240 
SREEVDAIER NFCPVEGACA GMFTANTMAS AAEALGMSLP GSASPPAPDR RRDGFARASG 

       250        260        270        280        290        300 
EAVVNLLRRG ITARDIMTRE AFENAIAVVM ALGGSTNAVL HLLAIAREAN VDLAIDDFNR 

       310        320        330        340        350        360 
IGDRVPHLAD VKPFGRYVMS DVDRVGGVPV VMKALLDAGL LHGDCLTVTG KTVAENLADI 

       370        380        390        400        410        420 
TPPDPDGKVI HALTQPIHRT GGLAILRGSL APDGAVVKTA GLESTFFEGT ARVFDGEEAA 

       430        440        450        460        470        480 
MRAVPELRPG DVVVIRYEGP KGGPGMREML AVTGAIKGAG LGKDVLLVTD GRFSGGTTGF 

       490        500        510        520        530        540 
CVAHVAPEAV DGGPIAFVRD GDRIRLDAQA RTLDLLVDAD ELAKRRADWQ PPPPRYTTGV 

       550 
AAKYVKLVGS ASEGAICR

« Hide

References

[1]"Complete sequence of Acidothermus cellulolyticus 11B."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000481 Genomic DNA. Translation: ABK52478.1.
RefSeqYP_872464.1. NC_008578.1.

3D structure databases

ProteinModelPortalA0LSR8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0LSR8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4486013.
GenomeReviewsGene locus Acel_0705 in contig CP000481_GR.
KEGGace:Acel_0705.
PATRIC20671804. VBIAciCel132453_0747.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0129.
HOGENOMHBG671001.
OMANMPGAMI.
PhylomeDBA0LSR8.
ProtClustDBPRK00911.

Enzyme and pathway databases

BioCycACEL351607:ACEL_0705-MONOMER.

Family and domain databases

HAMAPMF_00012. IlvD.
[Tree]
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
KOK01687.
PANTHERPTHR21000. ILVD_EDD_family. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00110. IlvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVD_ACIC1
AccessionPrimary (citable) accession number: A0LSR8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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