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Protein

ATP synthase subunit alpha

Gene

atpA

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei374Required for activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi173 – 180ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACEL351607:G1G7K-663-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alphaUniRule annotation (EC:3.6.3.14UniRule annotation)
Alternative name(s):
ATP synthase F1 sector subunit alphaUniRule annotation
F-ATPase subunit alphaUniRule annotation
Gene namesi
Name:atpAUniRule annotation
Ordered Locus Names:Acel_0651
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaAcidothermalesAcidothermaceaeAcidothermus
Proteomesi
  • UP000008221 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003026201 – 554ATP synthase subunit alphaAdd BLAST554

Proteomic databases

PRIDEiA0LSL4

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

Protein-protein interaction databases

STRINGi351607.Acel_0651

Structurei

3D structure databases

ProteinModelPortaliA0LSL4
SMRiA0LSL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDG Bacteria
COG0056 LUCA
HOGENOMiHOG000130111
KOiK02111
OMAiGNAQIKS
OrthoDBiPOG091H01QH

Family and domain databases

CDDicd01132 F1_ATPase_alpha, 1 hit
Gene3Di1.20.150.20, 1 hit
2.40.30.20, 1 hit
HAMAPiMF_01346 ATP_synth_alpha_bact, 1 hit
InterProiView protein in InterPro
IPR023366 ATP_synth_asu-like_sf
IPR000793 ATP_synth_asu_C
IPR038376 ATP_synth_asu_C_sf
IPR033732 ATP_synth_F1_a
IPR005294 ATP_synth_F1_asu
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF00306 ATP-synt_ab_C, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
SUPFAMiSSF50615 SSF50615, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00962 atpA, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

A0LSL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELTIRPEE IRAALEEFVS SYTPDVASRE EVGRVTEAGD GIARIEGLPS
60 70 80 90 100
TMANELLRFE DGTLGLALNL DVREIGAVIL GPFEGIEEGQ TVKRTGEVLS
110 120 130 140 150
VPVGDGFLGR VVDPLGRPLD GKGEIVAEGR RALEIQAPSV VQRQPVKEPL
160 170 180 190 200
QTGIKAIDAM TAIGRGQREL IIGDRQTGKT AVAIDTIINQ RANWESGDPK
210 220 230 240 250
LQVKCIYVAI GQKGSTIAAV RSALEAAGAM EYTTIVAAPA SDPAGFKYLA
260 270 280 290 300
PYTGSAIGQH WMYKGQHALI VFDDLSKQAE AYRAISLLLR RPPGREAYPG
310 320 330 340 350
DVFYLHSRLL ERCAKLSDAM GGGSLTGLPI IETKGNDVSA YIPTNVISIT
360 370 380 390 400
DGQIFLETDL FNSGVRPAIN VGISVSRVGG NAQLKAMKQV AGRLRLDLAQ
410 420 430 440 450
YRELEAFAAF GSDLDAASRA QLERGARLVE LLKQPQYSPY PVEEQVVSLW
460 470 480 490 500
AGTTGQLDDV PVTDIRRFER DFLEYVRLRH HGIFDEILKT GELTDNVVES
510 520 530 540 550
LKLAIAEFKQ TFETHDGKIL GHEEAPQLDE SHLAAEKVRK HVPPSKPTTQ

RTAG
Length:554
Mass (Da):60,166
Last modified:December 12, 2006 - v1
Checksum:i65B75FED9A685EA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA Translation: ABK52424.1
RefSeqiWP_011719487.1, NC_008578.1

Genome annotation databases

EnsemblBacteriaiABK52424; ABK52424; Acel_0651
KEGGiace:Acel_0651

Similar proteinsi

Entry informationi

Entry nameiATPA_ACIC1
AccessioniPrimary (citable) accession number: A0LSL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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