Reviewed, UniProtKB/Swiss-Prot A0LS98 (AROA_ACIC1)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
      Short name=EPSP synthase
      Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Acel_0535

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 423	423	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000099658

Sequences

	Sequence		Length	Mass (Da)
	A0LS98-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 646E607EBB8EC075	FASTA	423	44,002
	10 20 30 40 50 60 MTTTELTGWP APTASGRVDA VVHLPGSKSM TNRALVLAAL AAEPTAIRGG LRARDTELMM 70 80 90 100 110 120 AGLRSLGVGI DDAGDMWLVS PAELRGPAAI DCGLAGTVMR FLLAAATLAT GEVSFDGDPR 130 140 150 160 170 180 ARERPLRPLL DALRQLGAEL RDTGGRLPVT VVGSGHLPGG HCVVDASASS QFVSALLLVA 190 200 210 220 230 240 PRADTPVTVG HVGRTLPSVP HITMTVAMLR ERGVEVAGTD GSWRVQPGPI RGGTVQIEPD 250 260 270 280 290 300 LSNAAPFLAA ALVTGGRVRV PDWPMRTTQA GDALRDLLTA MGARCELDAT GLTVTGGPVI 310 320 330 340 350 360 HGLDADLRDV SELVPTLAAL AALADRPSTF RGIGHMRGHE TDRLAALAAE LTRLGGDVTA 370 380 390 400 410 420 TDDGLVIRPR PLHGGVFHSY GDHRMATTGA VLGLVIPGIV VENIQTVAKT MPTFVELWTG MLR

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000481 Genomic DNA. Translation: ABK52308.1.
RefSeq	YP_872294.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0LS98.
Genome annotation databases
GeneID	4485118.
GenomeReviews	Gene locus Acel_0535 in contig CP000481_GR.
KEGG	ace:Acel_0535.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HRMATAG.
Family and domain databases
HAMAP	MF_00210. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. [Graphical view]
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_ACIC1

Accession

Primary (citable) accession number: A0LS98

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)