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A0LRT5 (A0LRT5_ACIC1) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing] HAMAP MF_00344
EC=6.3.5.2 HAMAP MF_00344
Alternative name(s):
GMP synthetase HAMAP MF_00344
Glutamine amidotransferase HAMAP MF_00344
Gene names
Name:guaA HAMAP MF_00344
Ordered Locus Names:Acel_0371
OrganismAcidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]
Taxonomic identifier351607 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_00344

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_00344

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_00344

Subunit structure

Homodimer By similarity. HAMAP MF_00344

Sequence similarities

Contains 1 GMP-binding domain. HAMAP MF_00344

Contains 1 glutamine amidotransferase type-1 domain. HAMAP MF_00344

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain12 – 202191Glutamine amidotransferase type-1 By similarity HAMAP MF_00344
Domain234 – 397164GMP-binding By similarity HAMAP MF_00344
Nucleotide binding230 – 2367ATP By similarity HAMAP MF_00344

Sites

Active site891Nucleophile By similarity HAMAP MF_00344
Active site1761 By similarity HAMAP MF_00344
Active site1781 By similarity HAMAP MF_00344

Sequences

Sequence LengthMass (Da)Tools
A0LRT5 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: F989302C02F58D41

FASTA52256,090
        10         20         30         40         50         60 
MTESSGPRPR RPVLVIDFGA QYAQLIARRV RELGHYSEIV PHHADAAEVA TREPLALILS 

        70         80         90        100        110        120 
GGPASVYEPG APALNPKIFE LGVPVFGICY GFQLMAATLG GSVANTGGAE FGATPLRAAG 

       130        140        150        160        170        180 
SSRLFAGLPE EQTVWMSHRD TVSAAPPGFQ VAAATPNTRI AAFENPERRM AGVQFHPEVR 

       190        200        210        220        230        240 
HTEYGQAILR RFLQDIAGLK PDWTPSNIVS ELVTAIREQI GDGYAICGLS GGVDSAVAAA 

       250        260        270        280        290        300 
LVQRAIGDRL TCVFVDHGLL RAGEAEQVEQ DFVAATGVRL HVVDAADRFL AALSGVVDPE 

       310        320        330        340        350        360 
EKRRIIGREF IRVFEAAAQD IAASAPVEFL VQGTLYPDVV ESGGGANAAT IKSHHNVGGL 

       370        380        390        400        410        420 
PPDLRFRLVE PLRTLFKDEV RAVGAELGLP ESLVWRQPFP GPGLAVRIIG EVTRDRLSVL 

       430        440        450        460        470        480 
RRADAVVREE LTAAGLDRAI WQCPVVLLAD VRSVGVQGDG RTYGHPVVLR PVTSEDAMTA 

       490        500        510        520 
DWARIPHDVL AHISTRLTNE IPEINRVVLD ITSKPPATIE WE

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References

[1]"Complete sequence of Acidothermus cellulolyticus 11B."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000481 Genomic DNA. Translation: ABK52145.1.
RefSeqYP_872131.1. NC_008578.1.

3D structure databases

ProteinModelPortalA0LRT5.
SMRA0LRT5. Positions 13-522.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0LRT5.

Protein family/group databases

MEROPSC26.A17.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4485782.
GenomeReviewsGene locus Acel_0371 in contig CP000481_GR.
KEGGace:Acel_0371.
PATRIC20671108. VBIAciCel132453_0401.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0519.
HOGENOMHBG391775.
OMADGRTYEY.
ProtClustDBPRK00074.

Family and domain databases

HAMAPMF_00344. GMP_synthase.
[Tree]
InterProIPR017926. GATASE_1.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01951.
PfamPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00884. GuaA_Cterm. 1 hit.
TIGR00888. GuaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0LRT5_ACIC1
AccessionPrimary (citable) accession number: A0LRT5
Entry history
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info