Reviewed, UniProtKB/Swiss-Prot A0LRS4 (GCP_ACIC1)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	Acel_0360

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303242
Sites
	Metal binding	114	1	Zinc Potential
	Metal binding	118	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	A0LRS4-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 9BF146B69DB5FD2A	FASTA	343	35,112
	10 20 30 40 50 60 MTDEPLVLGI ETSCDETGVG VVRGRTLLAN EIASSVDLHA RFGGVVPEVA SRAHLEALVP 70 80 90 100 110 120 TMHRALEKAG LRLADVDAIA VTAGPGLAGT LLVGVAAAKA YALALGKPLF GVNHLAAHVA 130 140 150 160 170 180 VDILEHGPLP RPCVALLVSG GHSSLLLVED VTGTVRPLGS TVDDAAGEAF DKVARVLGLP 190 200 210 220 230 240 FPGGPPIDRA AQEGDPQFVA FPRGKADDGT FDFSFAGLKT AVARWVEKRE RDGEPVPVAD 250 260 270 280 290 300 VAAAFQEAVA DVLTAKAVAA CRTYGVGDLL IGGGVAANSR LRSLAAERCE AAGIRLRVPR 310 320 330 340 PGLCTDNGAM VAALGACLIK AGRTPSEPEF PADSSLPITE VLV

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000481 Genomic DNA. Translation: ABK52134.1.
RefSeq	YP_872120.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0LRS4.
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	4485899.
GenomeReviews	Gene locus Acel_0360 in contig CP000481_GR.
KEGG	ace:Acel_0360.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EHSAYGG.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_ACIC1

Accession

Primary (citable) accession number: A0LRS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)