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A0LRR9

- A0LRR9_ACIC1

UniProt

A0LRR9 - A0LRR9_ACIC1

Protein

Alanine racemase

Gene

Acel_0355

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei59 – 591Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei157 – 1571SubstrateUniRule annotation
    Active sitei291 – 2911Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei340 – 3401Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciACEL351607:GIXW-367-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Acel_0355Imported
    OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)Imported
    Taxonomic identifieri351607 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus
    ProteomesiUP000008221: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei59 – 591N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi351607.Acel_0355.

    Structurei

    3D structure databases

    ProteinModelPortaliA0LRR9.
    SMRiA0LRR9. Positions 27-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiGHTWTAQ.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0LRR9-1 [UniParc]FASTAAdd to Basket

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    MTVSGARGSP AWAAEELAGP ELGVARASRA QAVVDLGAIR ENVRRLRAVT    50
    GVDVMAVVKA DGYGHGLLPA ARAAVRGGAS WLGVAFVEEA LALRMAGIDV 100
    PILCLLAAPG ERFAEAIAAD VDLAVSAEWA LSEVCRAATT AGRTARIHLE 150
    VDTGLSRGGA TPAEWPDLLA ATAQARAAGL VEVVGIWSHL VHGDNPEHAD 200
    TTVQVERFDE ALAVAERFGI RPAVRHLANS GGALLAPRTR YDLVRPGIAV 250
    YGLSPAPALV SAGELGLRPA MHLRAQVALV KELPAGEGIS YGHRYRTLRP 300
    TRVALIPLGY ADGIPRQATN VAPVWFPAVG RRTISGTVCM DQFVVDVGPD 350
    APVAAGDDVV IFGPGDDGEP TADEWASAVG TISYEIVSRI GARVPRVYRD 400
    DDTAG 405
    Length:405
    Mass (Da):42,200
    Last modified:December 12, 2006 - v1
    Checksum:i22D95F5798F14ECE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000481 Genomic DNA. Translation: ABK52129.1.
    RefSeqiYP_872115.1. NC_008578.1.

    Genome annotation databases

    EnsemblBacteriaiABK52129; ABK52129; Acel_0355.
    GeneIDi4485894.
    KEGGiace:Acel_0355.
    PATRICi20671076. VBIAciCel132453_0385.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000481 Genomic DNA. Translation: ABK52129.1 .
    RefSeqi YP_872115.1. NC_008578.1.

    3D structure databases

    ProteinModelPortali A0LRR9.
    SMRi A0LRR9. Positions 27-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351607.Acel_0355.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK52129 ; ABK52129 ; Acel_0355 .
    GeneIDi 4485894.
    KEGGi ace:Acel_0355.
    PATRICi 20671076. VBIAciCel132453_0385.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi GHTWTAQ.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci ACEL351607:GIXW-367-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43068 / 11BImported.

    Entry informationi

    Entry nameiA0LRR9_ACIC1
    AccessioniPrimary (citable) accession number: A0LRR9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 12, 2006
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3