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A0LRJ4

- NUON_ACIC1

UniProt

A0LRJ4 - NUON_ACIC1

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Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciACEL351607:GIXW-288-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit NUniRule annotation
NDH-1 subunit NUniRule annotation
Gene namesi
Name:nuoNUniRule annotation
Ordered Locus Names:Acel_0280
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus
ProteomesiUP000008221: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalUniRule annotationAdd
BLAST
Transmembranei53 – 7321HelicalUniRule annotationAdd
BLAST
Transmembranei87 – 10721HelicalUniRule annotationAdd
BLAST
Transmembranei141 – 16121HelicalUniRule annotationAdd
BLAST
Transmembranei163 – 18321HelicalUniRule annotationAdd
BLAST
Transmembranei198 – 21821HelicalUniRule annotationAdd
BLAST
Transmembranei242 – 26221HelicalUniRule annotationAdd
BLAST
Transmembranei287 – 30721HelicalUniRule annotationAdd
BLAST
Transmembranei310 – 33021HelicalUniRule annotationAdd
BLAST
Transmembranei336 – 35621HelicalUniRule annotationAdd
BLAST
Transmembranei363 – 38321HelicalUniRule annotationAdd
BLAST
Transmembranei406 – 42621HelicalUniRule annotationAdd
BLAST
Transmembranei442 – 46120HelicalUniRule annotationAdd
BLAST
Transmembranei483 – 50321HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519NADH-quinone oxidoreductase subunit NPRO_0000391089Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi351607.Acel_0280.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1007.
HOGENOMiHOG000100794.
KOiK00343.
OMAiSATMFYL.
OrthoDBiEOG64JFNZ.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LRJ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFYAAANPN AIPAPHIEYR ALLPMLIVFG VACAGVLVEA FVPRAQRALT
60 70 80 90 100
QTVLALGGLV AALIAVVSNT GLPRKLVAQS AIAADGPTLF IQGTILALSI
110 120 130 140 150
GALLLIADRS IGADSDFVAQ AADLPGSEQE RASVQAGLRQ TEVFPLAMFA
160 170 180 190 200
VGGMMLFPAA NDLITAFVAL EVLSLPLYLL AGMARRRRLL SQEAAVKYFL
210 220 230 240 250
LGAFSSAFFV YGLALVYGYA KSVEYGDIAT ALTASDRGDS LIIVGLALIG
260 270 280 290 300
ISLLFKLSGV PFHWWTPDVY QGAPTPITAF MAAGTKVAAF GALLRVFFVA
310 320 330 340 350
FGGLAWDWRP VIWGVAIATM VVGAILGITQ TDVKRLLAYS SIAHAGFVLT
360 370 380 390 400
AFAATTRASE SSVLFYLVAY GFMTIGAFAI VILVRDGDGE ANHLSRWVGL
410 420 430 440 450
GRRSPLVAGI FALFLLAMAG LPPTSGLWAK VAVFTAAYQG GAGPLVIVGV
460 470 480 490 500
LASAVTAYYY LRIIVLMFAQ EPAVEGPTVA VPGALASAAI ALGVIVTVVL
510
GIVPQPVLDL ADKAVPFLR
Length:519
Mass (Da):54,151
Last modified:December 12, 2006 - v1
Checksum:i50D0124954A29947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK52054.1.
RefSeqiWP_011719117.1. NC_008578.1.
YP_872040.1. NC_008578.1.

Genome annotation databases

EnsemblBacteriaiABK52054; ABK52054; Acel_0280.
GeneIDi4486543.
KEGGiace:Acel_0280.
PATRICi20670910. VBIAciCel132453_0306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK52054.1 .
RefSeqi WP_011719117.1. NC_008578.1.
YP_872040.1. NC_008578.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351607.Acel_0280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK52054 ; ABK52054 ; Acel_0280 .
GeneIDi 4486543.
KEGGi ace:Acel_0280.
PATRICi 20670910. VBIAciCel132453_0306.

Phylogenomic databases

eggNOGi COG1007.
HOGENOMi HOG000100794.
KOi K00343.
OMAi SATMFYL.
OrthoDBi EOG64JFNZ.

Enzyme and pathway databases

BioCyci ACEL351607:GIXW-288-MONOMER.

Family and domain databases

HAMAPi MF_00445. NDH1_NuoN_1.
InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43068 / 11B.

Entry informationi

Entry nameiNUON_ACIC1
AccessioniPrimary (citable) accession number: A0LRJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3