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A0LRJ4

- NUON_ACIC1

UniProt

A0LRJ4 - NUON_ACIC1

Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciACEL351607:GIXW-288-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit NUniRule annotation
    NDH-1 subunit NUniRule annotation
    Gene namesi
    Name:nuoNUniRule annotation
    Ordered Locus Names:Acel_0280
    OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
    Taxonomic identifieri351607 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus
    ProteomesiUP000008221: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519NADH-quinone oxidoreductase subunit NPRO_0000391089Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi351607.Acel_0280.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalUniRule annotationAdd
    BLAST
    Transmembranei53 – 7321HelicalUniRule annotationAdd
    BLAST
    Transmembranei87 – 10721HelicalUniRule annotationAdd
    BLAST
    Transmembranei141 – 16121HelicalUniRule annotationAdd
    BLAST
    Transmembranei163 – 18321HelicalUniRule annotationAdd
    BLAST
    Transmembranei198 – 21821HelicalUniRule annotationAdd
    BLAST
    Transmembranei242 – 26221HelicalUniRule annotationAdd
    BLAST
    Transmembranei287 – 30721HelicalUniRule annotationAdd
    BLAST
    Transmembranei310 – 33021HelicalUniRule annotationAdd
    BLAST
    Transmembranei336 – 35621HelicalUniRule annotationAdd
    BLAST
    Transmembranei363 – 38321HelicalUniRule annotationAdd
    BLAST
    Transmembranei406 – 42621HelicalUniRule annotationAdd
    BLAST
    Transmembranei442 – 46120HelicalUniRule annotationAdd
    BLAST
    Transmembranei483 – 50321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 2 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1007.
    HOGENOMiHOG000100794.
    KOiK00343.
    OMAiSATMFYL.
    OrthoDBiEOG64JFNZ.

    Family and domain databases

    HAMAPiMF_00445. NDH1_NuoN_1.
    InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0LRJ4-1 [UniParc]FASTAAdd to Basket

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    MSFYAAANPN AIPAPHIEYR ALLPMLIVFG VACAGVLVEA FVPRAQRALT    50
    QTVLALGGLV AALIAVVSNT GLPRKLVAQS AIAADGPTLF IQGTILALSI 100
    GALLLIADRS IGADSDFVAQ AADLPGSEQE RASVQAGLRQ TEVFPLAMFA 150
    VGGMMLFPAA NDLITAFVAL EVLSLPLYLL AGMARRRRLL SQEAAVKYFL 200
    LGAFSSAFFV YGLALVYGYA KSVEYGDIAT ALTASDRGDS LIIVGLALIG 250
    ISLLFKLSGV PFHWWTPDVY QGAPTPITAF MAAGTKVAAF GALLRVFFVA 300
    FGGLAWDWRP VIWGVAIATM VVGAILGITQ TDVKRLLAYS SIAHAGFVLT 350
    AFAATTRASE SSVLFYLVAY GFMTIGAFAI VILVRDGDGE ANHLSRWVGL 400
    GRRSPLVAGI FALFLLAMAG LPPTSGLWAK VAVFTAAYQG GAGPLVIVGV 450
    LASAVTAYYY LRIIVLMFAQ EPAVEGPTVA VPGALASAAI ALGVIVTVVL 500
    GIVPQPVLDL ADKAVPFLR 519
    Length:519
    Mass (Da):54,151
    Last modified:December 12, 2006 - v1
    Checksum:i50D0124954A29947
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000481 Genomic DNA. Translation: ABK52054.1.
    RefSeqiWP_011719117.1. NC_008578.1.
    YP_872040.1. NC_008578.1.

    Genome annotation databases

    EnsemblBacteriaiABK52054; ABK52054; Acel_0280.
    GeneIDi4486543.
    KEGGiace:Acel_0280.
    PATRICi20670910. VBIAciCel132453_0306.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000481 Genomic DNA. Translation: ABK52054.1 .
    RefSeqi WP_011719117.1. NC_008578.1.
    YP_872040.1. NC_008578.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351607.Acel_0280.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK52054 ; ABK52054 ; Acel_0280 .
    GeneIDi 4486543.
    KEGGi ace:Acel_0280.
    PATRICi 20670910. VBIAciCel132453_0306.

    Phylogenomic databases

    eggNOGi COG1007.
    HOGENOMi HOG000100794.
    KOi K00343.
    OMAi SATMFYL.
    OrthoDBi EOG64JFNZ.

    Enzyme and pathway databases

    BioCyci ACEL351607:GIXW-288-MONOMER.

    Family and domain databases

    HAMAPi MF_00445. NDH1_NuoN_1.
    InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43068 / 11B.

    Entry informationi

    Entry nameiNUON_ACIC1
    AccessioniPrimary (citable) accession number: A0LRJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 9, 2010
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3