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A0LRE5

- GSA_ACIC1

UniProt

A0LRE5 - GSA_ACIC1

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciACEL351607:GIXW-239-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:Acel_0231
    OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
    Taxonomic identifieri351607 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus
    ProteomesiUP000008221: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000300886Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei271 – 2711N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi351607.Acel_0231.

    Structurei

    3D structure databases

    ProteinModelPortaliA0LRE5.
    SMRiA0LRE5. Positions 1-426.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiADIAHEN.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0LRE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSPGTDAVS AACFERARAR IPGGVNSPVR AFRAVGGTPR FIQSGAGPYL    50
    VDVDGNRYVD LVCSWGPLIL GHAHPAVVAA VKQAAERGTS FGAPTEAEIE 100
    MAEEIARRVP AVEMIRLVNS GTEATMSALR LARAYTNRPL VVKFAGCYHG 150
    HVDALLSAAG SGVATLGLPG TPGVTPGQAA ETIVLPYNDI DAVRTAFERY 200
    GGEIACVIVE AAAANMGVVP PEPGFNRALA DIAHENGALL VLDEVLTGFR 250
    VSSAGWWGRD PVAADLFTFG KVIGGGLPIG AFGGRRDIMQ LLAPAGTVYQ 300
    AGTLSGNPVA VAAGLATLRE STPDIYARLD HVAAVLARAL RDEFGRIGLP 350
    HQVQQAGNLF SVFFTTEPVR NYAQATGQEA WRYPPFFHAL LDRGVHPPPS 400
    VYEAWFVSAA HDDAAVNQIL DALPAAVRAA ADARPPG 437
    Length:437
    Mass (Da):45,713
    Last modified:December 12, 2006 - v1
    Checksum:i828795AA4811CA3F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000481 Genomic DNA. Translation: ABK52005.1.
    RefSeqiWP_011719069.1. NC_008578.1.
    YP_871991.1. NC_008578.1.

    Genome annotation databases

    EnsemblBacteriaiABK52005; ABK52005; Acel_0231.
    GeneIDi4485369.
    KEGGiace:Acel_0231.
    PATRICi20670806. VBIAciCel132453_0254.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000481 Genomic DNA. Translation: ABK52005.1 .
    RefSeqi WP_011719069.1. NC_008578.1.
    YP_871991.1. NC_008578.1.

    3D structure databases

    ProteinModelPortali A0LRE5.
    SMRi A0LRE5. Positions 1-426.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351607.Acel_0231.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK52005 ; ABK52005 ; Acel_0231 .
    GeneIDi 4485369.
    KEGGi ace:Acel_0231.
    PATRICi 20670806. VBIAciCel132453_0254.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi ADIAHEN.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci ACEL351607:GIXW-239-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43068 / 11B.

    Entry informationi

    Entry nameiGSA_ACIC1
    AccessioniPrimary (citable) accession number: A0LRE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3