Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A0LRE5

- GSA_ACIC1

UniProt

A0LRE5 - GSA_ACIC1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciACEL351607:GIXW-239-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:Acel_0231
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus
ProteomesiUP000008221: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000300886Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei271 – 2711N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi351607.Acel_0231.

Structurei

3D structure databases

ProteinModelPortaliA0LRE5.
SMRiA0LRE5. Positions 1-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiADIAHEN.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0LRE5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSPGTDAVS AACFERARAR IPGGVNSPVR AFRAVGGTPR FIQSGAGPYL
60 70 80 90 100
VDVDGNRYVD LVCSWGPLIL GHAHPAVVAA VKQAAERGTS FGAPTEAEIE
110 120 130 140 150
MAEEIARRVP AVEMIRLVNS GTEATMSALR LARAYTNRPL VVKFAGCYHG
160 170 180 190 200
HVDALLSAAG SGVATLGLPG TPGVTPGQAA ETIVLPYNDI DAVRTAFERY
210 220 230 240 250
GGEIACVIVE AAAANMGVVP PEPGFNRALA DIAHENGALL VLDEVLTGFR
260 270 280 290 300
VSSAGWWGRD PVAADLFTFG KVIGGGLPIG AFGGRRDIMQ LLAPAGTVYQ
310 320 330 340 350
AGTLSGNPVA VAAGLATLRE STPDIYARLD HVAAVLARAL RDEFGRIGLP
360 370 380 390 400
HQVQQAGNLF SVFFTTEPVR NYAQATGQEA WRYPPFFHAL LDRGVHPPPS
410 420 430
VYEAWFVSAA HDDAAVNQIL DALPAAVRAA ADARPPG
Length:437
Mass (Da):45,713
Last modified:December 12, 2006 - v1
Checksum:i828795AA4811CA3F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000481 Genomic DNA. Translation: ABK52005.1.
RefSeqiWP_011719069.1. NC_008578.1.
YP_871991.1. NC_008578.1.

Genome annotation databases

EnsemblBacteriaiABK52005; ABK52005; Acel_0231.
GeneIDi4485369.
KEGGiace:Acel_0231.
PATRICi20670806. VBIAciCel132453_0254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000481 Genomic DNA. Translation: ABK52005.1 .
RefSeqi WP_011719069.1. NC_008578.1.
YP_871991.1. NC_008578.1.

3D structure databases

ProteinModelPortali A0LRE5.
SMRi A0LRE5. Positions 1-426.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351607.Acel_0231.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK52005 ; ABK52005 ; Acel_0231 .
GeneIDi 4485369.
KEGGi ace:Acel_0231.
PATRICi 20670806. VBIAciCel132453_0254.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi ADIAHEN.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci ACEL351607:GIXW-239-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43068 / 11B.

Entry informationi

Entry nameiGSA_ACIC1
AccessioniPrimary (citable) accession number: A0LRE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3