Reviewed, UniProtKB/Swiss-Prot A0LRC5 (PANC_ACIC1)

Names and origin

Protein names

Recommended name:
    Pantothenate synthetase
      Short name=PS
    EC=6.3.2.1
Alternative name(s):
    Pantoate--beta-alanine ligase
    Pantoate-activating enzyme

Gene names

Name:	panC
Ordered Locus Names:	Acel_0211

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP MF_00158
Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP MF_00158
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP MF_00158
Subunit structure	Homodimer By similarity. HAMAP MF_00158
Subcellular location	Cytoplasm Potential HAMAP MF_00158.
Miscellaneous	The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity. HAMAP MF_00158
Sequence similarities	Belongs to the pantothenate synthetase family.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pantothenate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Pantothenate synthetase HAMAP MF_00158		PRO_0000305382
Regions
	Nucleotide binding	48 – 55	8	ATP By similarity
	Nucleotide binding	165 – 168	4	ATP By similarity
	Nucleotide binding	202 – 205	4	ATP By similarity
Sites
	Active site	55	1	Proton donor By similarity
	Binding site	79	1	Beta-alanine By similarity
	Binding site	79	1	Pantoate By similarity
	Binding site	171	1	Pantoate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0LRC5-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 4963B0D9CD3BC119	FASTA	303	32,219
	10 20 30 40 50 60 MIATGHGGAE RRTTAGDGTA RPVVARTIGE LRAARAALTG PVAFVPTMGA LHDGHRSLLR 70 80 90 100 110 120 IARHHGDHVV VSIFVNPLQF GPAEDFDRYP RTLDADLAMC AAEGVDLVFV PPAAEMYPSE 130 140 150 160 170 180 PQVRVSAGPL GERFEGSVRP GHFDGVLTVV AKLFQLVQPD VAVFGRKDAQ QLALVRRMVA 190 200 210 220 230 240 DLNLPVQIIA APTFREPDGL AASSRNRYLT DADRAQARAL PTALTTAAAV AAAGGPPSEM 250 260 270 280 290 300 IEMARKVLAD AAVTLDYVAV VDEATFDEID DAEWSQRGEG LCIAAIRVGG TRLIDNMPMR KAD

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000481 Genomic DNA. Translation: ABK51985.1.
RefSeq	YP_871971.1.
3D structure databases
SMR	A0LRC5. Positions 23-300.
ModBase	Search...
Protein-protein interaction databases
STRING	A0LRC5.
Genome annotation databases
GeneID	4486069.
GenomeReviews	Gene locus Acel_0211 in contig CP000481_GR.
KEGG	ace:Acel_0211.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0414.
HOGENOM	HBG428839.
OMA	EDFGSYP.
PhylomeDB	A0LRC5.
Family and domain databases
HAMAP	MF_00158. PanC. [Tree]
InterPro	IPR004821. Cyt_trans_rel. IPR003721. Pantoate_ligase. [Graphical view]
PANTHER	PTHR21299:SF1. Pantoate_ligase. 1 hit.
Pfam	PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00125. cyt_tran_rel. 1 hit. TIGR00018. panC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANC_ACIC1

Accession

Primary (citable) accession number: A0LRC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	December 12, 2006
Last modified:	February 9, 2010
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)