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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 3511D-inositol 3-phosphateUniRule annotation
Binding sitei49 – 491UDP-GlcNAc; via amide nitrogenUniRule annotation
Binding sitei104 – 10411D-inositol 3-phosphateUniRule annotation
Binding sitei137 – 13711D-inositol 3-phosphateUniRule annotation
Binding sitei161 – 16111D-inositol 3-phosphateUniRule annotation
Binding sitei181 – 18111D-inositol 3-phosphateUniRule annotation
Binding sitei255 – 2551UDP-GlcNAcUniRule annotation
Binding sitei260 – 2601UDP-GlcNAcUniRule annotation
Binding sitei321 – 3211UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation
Metal bindingi330 – 3301Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi331 – 3311Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi333 – 3331Magnesium; via carbonyl oxygenUniRule annotation
Binding sitei343 – 3431UDP-GlcNAcUniRule annotation
Binding sitei351 – 3511UDP-GlcNAcUniRule annotation
Metal bindingi357 – 3571MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciACEL351607:GIXW-78-MONOMER.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Acel_0073
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaAcidothermalesAcidothermaceaeAcidothermus
Proteomesi
  • UP000008221 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448D-inositol 3-phosphate glycosyltransferasePRO_0000400107Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi351607.Acel_0073.

Structurei

3D structure databases

ProteinModelPortaliA0LQY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 5161D-inositol 3-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiEOG647TVR.

Family and domain databases

HAMAPiMF_01695. MshA.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LQY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRWLSAPEH ARHRTVAASA GAPWTPRRVA MIAVHTSPLE IPGCGDAGGL
60 70 80 90 100
NVYVAQIARR LASRGIDVDV FTRATRRDLP PQQRLAPGVT VRNVVAGPLE
110 120 130 140 150
PLPKDELPVH LCAFTAAVLR AEAMREPGWY DVIHSHYWLS GEVGRVASQR
160 170 180 190 200
WGVPLVHTMH TLAKVKNAAL AEGDVPEPGR RVIGEADVVA AADRLVTNTW
210 220 230 240 250
TEARQLVDLY GAEPDRIRVV PPGVETAIFR PGDSARARRR LGLPIDGCVV
260 270 280 290 300
LFVGRLQPLK GPDIAVRAAA EFLSTHPGMR STFRLVIVGG PSGSRSTEPE
310 320 330 340 350
RLRALAADLG VADAVIFAPP MPPDRLVEFY RAATVTIVPS HSESFGLVAL
360 370 380 390 400
ESQACGTPVV AARVGGLTTA VRDGESGLLV DGHDPARYAG AIGRLLDPGL
410 420 430 440
RAELVRGAVA HAMRFHWDNT VEGILGVYRD ALAERRTAAT QRLASRVG
Length:448
Mass (Da):48,018
Last modified:December 12, 2006 - v1
Checksum:i3BA99E4D69C2AD72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK51849.1.
RefSeqiWP_011718913.1. NC_008578.1.

Genome annotation databases

EnsemblBacteriaiABK51849; ABK51849; Acel_0073.
KEGGiace:Acel_0073.
PATRICi20670446. VBIAciCel132453_0077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK51849.1.
RefSeqiWP_011718913.1. NC_008578.1.

3D structure databases

ProteinModelPortaliA0LQY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351607.Acel_0073.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK51849; ABK51849; Acel_0073.
KEGGiace:Acel_0073.
PATRICi20670446. VBIAciCel132453_0077.

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiEOG647TVR.

Enzyme and pathway databases

BioCyciACEL351607:GIXW-78-MONOMER.

Family and domain databases

HAMAPiMF_01695. MshA.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43068 / 11B.

Entry informationi

Entry nameiMSHA_ACIC1
AccessioniPrimary (citable) accession number: A0LQY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: December 12, 2006
Last modified: May 11, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.