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A0LQR5 (DDL_SYNFM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Sfum_4102
OrganismSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB) [Complete proteome] [HAMAP]
Taxonomic identifier335543 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000074802

Regions

Domain105 – 306202ATP-grasp
Nucleotide binding133 – 18856ATP By similarity

Sites

Metal binding2611Magnesium or manganese 1 By similarity
Metal binding2731Magnesium or manganese 1 By similarity
Metal binding2731Magnesium or manganese 2 By similarity
Metal binding2751Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
A0LQR5 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 5C2381283836A2CB

FASTA31133,650
        10         20         30         40         50         60 
MSTEKLTVAL LSGGASAERE VSLKSGEQVF NALDKQRYLV LRYDPAHDLT RLAADAEKID 

        70         80         90        100        110        120 
VALIILHGRM GEDGTIQGLL ESLGIPYQGS GVLGSAVAMN KILSKQLYIH AGLPVAPHLV 

       130        140        150        160        170        180 
ADRREPPDLD TVADRLGLPV VVKPEHEGSS IGLSIVRNRD QLAAAVETGW QYDRRCLIEK 

       190        200        210        220        230        240 
YVHGIEITGG VLGNDHLQAL PLIEIIPGEA YEFFDYKAKY TPGASREICP ARLSDTITAK 

       250        260        270        280        290        300 
AQEYARKAHQ ALCCKGYSRT DMIVSGNDIF ILETNTIPGM TATSLFPQAA AVAGISFSAL 

       310 
LDRLIELALE D 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000478 Genomic DNA. Translation: ABK19767.1.
RefSeqYP_848202.1. NC_008554.1.

3D structure databases

ProteinModelPortalA0LQR5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING335543.Sfum_4102.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK19767; ABK19767; Sfum_4102.
GeneID4457558.
KEGGsfu:Sfum_4102.
PATRIC23854633. VBISynFum78438_4865.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAKYMDFSR.
OrthoDBEOG6ND0KB.
ProtClustDBCLSK928465.

Enzyme and pathway databases

BioCycSFUM335543:GH6P-4161-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_SYNFM
AccessionPrimary (citable) accession number: A0LQR5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 12, 2006
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways