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A0LQR3

- GCH4_SYNFM

UniProt

A0LQR3 - GCH4_SYNFM

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei146 – 1461May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSFUM335543:GH6P-4159-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Sfum_4100
OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Taxonomic identifieri335543 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
ProteomesiUP000001784: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257GTP cyclohydrolase FolE2PRO_0000289527Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335543.Sfum_4100.

Structurei

3D structure databases

ProteinModelPortaliA0LQR3.
SMRiA0LQR3. Positions 12-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LQR3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MIDVQSRFDS RNIRVDKVGV KDIRYPITVM DKTNGIQHTV ASVNMYVNLP
60 70 80 90 100
REFKGTHMSR FIEILNEFHG NLDIREFPSI LQSVQEHLSA ESAHLELSFS
110 120 130 140 150
YFIKKLSPVT GCAGLMEYGC RVAGSLDSNR GHDLVLEVNV PISTVCPCSK
160 170 180 190 200
EISSYGAHNQ RGMVRLAVRF KKFVWIEDLV RLVECAASSE VYSVLKRPDE
210 220 230 240 250
KFVTESAFDN PKFVEDVVRD IAKELKADQN ISWFLVDVEN FESIHNHSAY

ACIERSK
Length:257
Mass (Da):29,236
Last modified:December 12, 2006 - v1
Checksum:iC4E27A7ADE828D9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000478 Genomic DNA. Translation: ABK19765.1.
RefSeqiYP_848200.1. NC_008554.1.

Genome annotation databases

EnsemblBacteriaiABK19765; ABK19765; Sfum_4100.
GeneIDi4457556.
KEGGisfu:Sfum_4100.
PATRICi23854629. VBISynFum78438_4863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000478 Genomic DNA. Translation: ABK19765.1 .
RefSeqi YP_848200.1. NC_008554.1.

3D structure databases

ProteinModelPortali A0LQR3.
SMRi A0LQR3. Positions 12-257.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335543.Sfum_4100.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK19765 ; ABK19765 ; Sfum_4100 .
GeneIDi 4457556.
KEGGi sfu:Sfum_4100.
PATRICi 23854629. VBISynFum78438_4863.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci SFUM335543:GH6P-4159-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10017 / MPOB.

Entry informationi

Entry nameiGCH4_SYNFM
AccessioniPrimary (citable) accession number: A0LQR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3