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A0LQR3 (GCH4_SYNFM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Sfum_4100
OrganismSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB) [Complete proteome] [HAMAP]
Taxonomic identifier335543 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289527

Sites

Site1461May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
A0LQR3 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: C4E27A7ADE828D9F

FASTA25729,236
        10         20         30         40         50         60 
MIDVQSRFDS RNIRVDKVGV KDIRYPITVM DKTNGIQHTV ASVNMYVNLP REFKGTHMSR 

        70         80         90        100        110        120 
FIEILNEFHG NLDIREFPSI LQSVQEHLSA ESAHLELSFS YFIKKLSPVT GCAGLMEYGC 

       130        140        150        160        170        180 
RVAGSLDSNR GHDLVLEVNV PISTVCPCSK EISSYGAHNQ RGMVRLAVRF KKFVWIEDLV 

       190        200        210        220        230        240 
RLVECAASSE VYSVLKRPDE KFVTESAFDN PKFVEDVVRD IAKELKADQN ISWFLVDVEN 

       250 
FESIHNHSAY ACIERSK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000478 Genomic DNA. Translation: ABK19765.1.
RefSeqYP_848200.1. NC_008554.1.

3D structure databases

ProteinModelPortalA0LQR3.
SMRA0LQR3. Positions 12-257.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING335543.Sfum_4100.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK19765; ABK19765; Sfum_4100.
GeneID4457556.
KEGGsfu:Sfum_4100.
PATRIC23854629. VBISynFum78438_4863.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMADVQSSRD.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycSFUM335543:GH6P-4159-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00294. TIGR00294. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCH4_SYNFM
AccessionPrimary (citable) accession number: A0LQR3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways