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A0LQR3

- GCH4_SYNFM

UniProt

A0LQR3 - GCH4_SYNFM

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei146 – 1461May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciSFUM335543:GH6P-4159-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Sfum_4100
    OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
    Taxonomic identifieri335543 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
    ProteomesiUP000001784: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257GTP cyclohydrolase FolE2PRO_0000289527Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi335543.Sfum_4100.

    Structurei

    3D structure databases

    ProteinModelPortaliA0LQR3.
    SMRiA0LQR3. Positions 12-257.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0LQR3-1 [UniParc]FASTAAdd to Basket

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    MIDVQSRFDS RNIRVDKVGV KDIRYPITVM DKTNGIQHTV ASVNMYVNLP    50
    REFKGTHMSR FIEILNEFHG NLDIREFPSI LQSVQEHLSA ESAHLELSFS 100
    YFIKKLSPVT GCAGLMEYGC RVAGSLDSNR GHDLVLEVNV PISTVCPCSK 150
    EISSYGAHNQ RGMVRLAVRF KKFVWIEDLV RLVECAASSE VYSVLKRPDE 200
    KFVTESAFDN PKFVEDVVRD IAKELKADQN ISWFLVDVEN FESIHNHSAY 250
    ACIERSK 257
    Length:257
    Mass (Da):29,236
    Last modified:December 12, 2006 - v1
    Checksum:iC4E27A7ADE828D9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000478 Genomic DNA. Translation: ABK19765.1.
    RefSeqiWP_011700878.1. NC_008554.1.
    YP_848200.1. NC_008554.1.

    Genome annotation databases

    EnsemblBacteriaiABK19765; ABK19765; Sfum_4100.
    GeneIDi4457556.
    KEGGisfu:Sfum_4100.
    PATRICi23854629. VBISynFum78438_4863.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000478 Genomic DNA. Translation: ABK19765.1 .
    RefSeqi WP_011700878.1. NC_008554.1.
    YP_848200.1. NC_008554.1.

    3D structure databases

    ProteinModelPortali A0LQR3.
    SMRi A0LQR3. Positions 12-257.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335543.Sfum_4100.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK19765 ; ABK19765 ; Sfum_4100 .
    GeneIDi 4457556.
    KEGGi sfu:Sfum_4100.
    PATRICi 23854629. VBISynFum78438_4863.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci SFUM335543:GH6P-4159-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 10017 / MPOB.

    Entry informationi

    Entry nameiGCH4_SYNFM
    AccessioniPrimary (citable) accession number: A0LQR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3