A0LPR9 (A0LPR9_SYNFM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase HAMAP MF_00392
EC=2.4.1.182 HAMAP MF_00392

Gene names

Name:	lpxB HAMAP MF_00392
Ordered Locus Names:	Sfum_3751

Organism

Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) [Complete proteome] [HAMAP]

Taxonomic identifier

335543 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Syntrophobacterales › Syntrophobacteraceae › Syntrophobacter

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00392 SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP MF_00392 SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP MF_00392 SAAS SAAS003835
Sequence similarities	Belongs to the lpxB family. HAMAP MF_00392

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00392 SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase HAMAP MF_00392 SAAS SAAS003835 EMBL ABK19421.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0LPR9 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 29B97C3544A38E02	FASTA	384	42,503
	10 20 30 40 50 60 MGAFAQRPPR VFLSAGEASG DLHGAGFVRA LKELRPDVRV ACLGGTMLRN AGAEVLADNK 70 80 90 100 110 120 EIAVVGLTEV LRHAKDIFNA WKRIRNHIVR QRPDLIVLID FPDFNFLLAR LARRCGMKIL 130 140 150 160 170 180 YYVSPQVWAW RSGRVRTLKR VVDEMAVILP FEVDFYRRHG MAVRYVGHPL LDAVRNAPPR 190 200 210 220 230 240 DEALTRYGAA DGSLLIGLLP GSRQSEVRLV FPVLIEAARR LRERMPGLSF IVPAAPTLAP 250 260 270 280 290 300 EPIRSALAEA KLPARVVSGD TYGVIRACDL IVTVSGTVTL EAALLDTPMI IVNRVSRLSY 310 320 330 340 350 360 TLGRDLIRVR YVGLPNLIAG RGVVPELLQQ EARADIVCER VLDFLRDPAL PAAQRRAFAG 370 380 IRERLGQPGV ARRVATMALR MLEP

References

[1]

"Complete sequence of Syntrophobacter fumaroxidans MPOB." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.G., Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Boone D.R. , Brockman F., Culley D., Ferry J., Gunsalus R., McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J., Sieber J., Stams A.J.M., Worm P., Henstra A.M., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 10017 / MPOB.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000478 Genomic DNA. Translation: ABK19421.1.
RefSeq	YP_847856.1. NC_008554.1.
3D structure databases
ProteinModelPortal	A0LPR9.
ModBase	Search...
Protein-protein interaction databases
STRING	A0LPR9.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4457918.
GenomeReviews	Gene locus Sfum_3751 in contig CP000478_GR.
KEGG	sfu:Sfum_3751.
NMPDR	fig|335543.6.peg.3869.
PATRIC	23853839. VBISynFum78438_4469.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	AEFAFIC.
PhylomeDB	A0LPR9.
Enzyme and pathway databases
BioCyc	SFUM335543:SFUM_3751-MONOMER.
Family and domain databases
HAMAP	MF_00392. LpxB. [Tree]
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0LPR9_SYNFM

Accession

Primary (citable) accession number: A0LPR9

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)