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Protein
Submitted name:

2-oxoglutarate dehydrogenase E1 component

Gene

Sfum_3547

Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Enzyme and pathway databases

BioCyciSFUM335543:GH6P-3602-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
2-oxoglutarate dehydrogenase E1 componentImported (EC:1.2.4.2Imported)
Gene namesi
Ordered Locus Names:Sfum_3547Imported
OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)Imported
Taxonomic identifieri335543 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
ProteomesiUP000001784: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi335543.Sfum_3547.

Structurei

3D structure databases

ProteinModelPortaliA0LP65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259587.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LP65-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MEFSIGWNAD YIDAQYRLWK SDPKKVSREW RIFFEGFELA SFPEPSGICD
60 70 80 90 100
REEVLLQAGV QELIHRYRDI GHLLACLDPL ASCPIDHPLL RLSSFNLSEA
110 120 130 140 150
ALDRNVQAPG FLHSKRMPLR EIVSILRDTY CGSVGVEYMH LQDPSERAWL
160 170 180 190 200
QDRMEPIRNR PDPAADEKLA ILSVLTRATL FEQFLHTKYV GQKRFSLEGA
210 220 230 240 250
EVVTAMLDSL LRRAAEAQCR EVILGMAHRG RLNVLVNVLR KPYSDIFCEF
260 270 280 290 300
EDHYDPESMV GSGDVKYHKG YMADLEIPGG RSLRVLLAAN PSHLEAVDPV
310 320 330 340 350
VEGIARARQD GCGDCLRRQV LSVLLHGDAA FAGQGVVAET LNLSLLEGYS
360 370 380 390 400
TGGTIHVVVN NQIGFTTLPD HARSTRYSTD VAKMLMVPIF HVHGEDPEAA
410 420 430 440 450
CFLVKLALDY RMEFAKDVVI DVVCFRRYGH NEGDEPYFTQ PVMYDRIKER
460 470 480 490 500
PQLWRGYAAK LRDEGVVSDG EIEAMQDGIR ECLEKAFDSV HDKTCPLPVN
510 520 530 540 550
RFIESWDDIG RDDPETPVET GVAEETLVSL ARGMNAFPSG FSVHPRLERI
560 570 580 590 600
LARRLESVEK GEGIDWATAE LLAFGTLLEE RTPVRLSGQD SLRGTFSHRH
610 620 630 640 650
SVLTDVKTGE RFTPLNALSP RQARYCGYDS MLSENAVLGF EYGYSLAEPR
660 670 680 690 700
TLVIWEAQFG DFANNAQVMI DQFISSGETK WQRRSGLVLL LPHGLEGQGA
710 720 730 740 750
EHSSARLERF LQLCAEDNIQ VCNPSTPAQY FHLLRRQVKR NVRKPLVVMA
760 770 780 790 800
PKSLLRHPLA VSAMADLSVG RFREVLDDPG ESEAPERVLF CSGKIYYDLV
810 820 830 840 850
GKRDEARTGR IPIIRIEQFH PFPERLLEEI AAKRSRAGEW VWVQEEPRNM
860 870 880 890 900
GGWGFVGPRL EALTGREVGF IGRKAAASPA TGSHRAHLAE QEAILREALK

L
Length:901
Mass (Da):101,344
Last modified:December 12, 2006 - v1
Checksum:i7A083F8661CED227
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000478 Genomic DNA. Translation: ABK19217.1.
RefSeqiYP_847652.1. NC_008554.1.

Genome annotation databases

EnsemblBacteriaiABK19217; ABK19217; Sfum_3547.
GeneIDi4458143.
KEGGisfu:Sfum_3547.
PATRICi23853331. VBISynFum78438_4218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000478 Genomic DNA. Translation: ABK19217.1.
RefSeqiYP_847652.1. NC_008554.1.

3D structure databases

ProteinModelPortaliA0LP65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi335543.Sfum_3547.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK19217; ABK19217; Sfum_3547.
GeneIDi4458143.
KEGGisfu:Sfum_3547.
PATRICi23853331. VBISynFum78438_4218.

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259587.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Enzyme and pathway databases

BioCyciSFUM335543:GH6P-3602-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10017 / MPOBImported.

Entry informationi

Entry nameiA0LP65_SYNFM
AccessioniPrimary (citable) accession number: A0LP65
Entry historyi
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: January 7, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.