A0LLU8 (AROD_SYNFM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	Sfum_2722

Organism

Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) [Complete proteome] [HAMAP]

Taxonomic identifier

335543 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Syntrophobacterales › Syntrophobacteraceae › Syntrophobacter

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 234	234	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000325531
Sites
	Active site	124	1	Proton acceptor By similarity
	Active site	151	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0LLU8 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 1DC43900AEBBCEB8	FASTA	234	25,847
	10 20 30 40 50 60 MSLAHSLICG CLMRESTEDT ARFLEYPGIG LVEWRLDALH GIHTRNGLDE ALAGLSLPGR 70 80 90 100 110 120 HPVIATVRPE RFRGGFRGTE EARIRALERT VRAGAEWIDL EDDLPEDVLS PFRDSAARVV 130 140 150 160 170 180 ISHHDFDGTP ASDPLKHRVE HLATLGAHVL KIATYARTVE DNLRVLELIP FARKQFGAET 190 200 210 220 230 IAFCMGPTGR WSRLACLLMG SPWTYVRFPE LPASAPGQFT VAQMQTLLEI VGAG

References

[1]

"Complete sequence of Syntrophobacter fumaroxidans MPOB." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.G., Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Boone D.R. , Brockman F., Culley D., Ferry J., Gunsalus R., McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J., Sieber J., Stams A.J.M., Worm P., Henstra A.M., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 10017 / MPOB.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000478 Genomic DNA. Translation: ABK18400.1.
RefSeq	YP_846835.1. NC_008554.1.
3D structure databases
ProteinModelPortal	A0LLU8.
ModBase	Search...
Protein-protein interaction databases
STRING	A0LLU8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4458951.
GenomeReviews	Gene locus Sfum_2722 in contig CP000478_GR.
KEGG	sfu:Sfum_2722.
NMPDR	fig|335543.6.peg.2803.
PATRIC	23851341. VBISynFum78438_3231.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0710.
OMA	HYIDVEA.
PhylomeDB	A0LLU8.
Enzyme and pathway databases
BioCyc	SFUM335543:SFUM_2722-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_SYNFM

Accession

Primary (citable) accession number: A0LLU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	December 12, 2006
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program