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A0LLR3

- FTHS_SYNFM

UniProt

A0LLR3 - FTHS_SYNFM

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi73 – 808ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSFUM335543:GH6P-2735-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Sfum_2687
    OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
    Taxonomic identifieri335543 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
    ProteomesiUP000001784: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 587587Formate--tetrahydrofolate ligasePRO_0000293071Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi335543.Sfum_2687.

    Structurei

    3D structure databases

    ProteinModelPortaliA0LLR3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiTWRRCLD.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0LLR3-1 [UniParc]FASTAAdd to Basket

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    MPYDATKMMD WQISEEAEKD MPSPWQWQEK LGLLKEEILP MGRLCKLDFL    50
    KIMNRLKDKP DGKYIEVTAI TPTPLGEGKS TTSVGLMEGL GKRGVNVGGC 100
    LRQPSGGPTM NIKGTAAGGG NALLIPMTEF SMGLTGDIND IMNAHNLAMV 150
    ALTARMQHER NYTDEQLDRL TKMRRLHIDP TRVEMGWIMD FCAQALRNII 200
    IGIGGRQDGY MMQSKFGIAV SSELMAILSI VKDLPDLRKR LNEITVAFDR 250
    RGNPVTTGDL EVGGAMTAFM RNTINPTLMC TAEYQPCMVH AGPFANIAVG 300
    QSSIIADRIG LKMFDYHVTE SGFAADIGFE KFWNVKCRYS GLKPHVSVLT 350
    TTIRALKMHG GGPKVVAGLA MPEEYTKENL KLLEKGIVNM VHHINTIRKS 400
    GMNPVVCINA FHTDTKDEIA LVRKHAEAAG ARCALSEHWA KGGEGALEFA 450
    DAVIDACKQE SQFKFLYPLE MKLRDRVSTV AREVYGADGV SWTPDAEAKA 500
    KMLENDPKYD DYATMMVKTH LSLTHDPSVK GVPKGWVLPI RDVLIYSGAK 550
    FLCPCAGTIS LMPGTSSNPA FRRIDVDVNT GKVKGLF 587
    Length:587
    Mass (Da):64,624
    Last modified:December 12, 2006 - v1
    Checksum:i174E693ECDA3007E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000478 Genomic DNA. Translation: ABK18365.1.
    RefSeqiYP_846800.1. NC_008554.1.

    Genome annotation databases

    EnsemblBacteriaiABK18365; ABK18365; Sfum_2687.
    GeneIDi4458986.
    KEGGisfu:Sfum_2687.
    PATRICi23851269. VBISynFum78438_3195.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000478 Genomic DNA. Translation: ABK18365.1 .
    RefSeqi YP_846800.1. NC_008554.1.

    3D structure databases

    ProteinModelPortali A0LLR3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335543.Sfum_2687.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK18365 ; ABK18365 ; Sfum_2687 .
    GeneIDi 4458986.
    KEGGi sfu:Sfum_2687.
    PATRICi 23851269. VBISynFum78438_3195.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi TWRRCLD.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SFUM335543:GH6P-2735-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 10017 / MPOB.

    Entry informationi

    Entry nameiFTHS_SYNFM
    AccessioniPrimary (citable) accession number: A0LLR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3