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A0LLR3

- FTHS_SYNFM

UniProt

A0LLR3 - FTHS_SYNFM

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 808ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSFUM335543:GH6P-2735-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Sfum_2687
OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Taxonomic identifieri335543 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
ProteomesiUP000001784: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Formate--tetrahydrofolate ligasePRO_0000293071Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335543.Sfum_2687.

Structurei

3D structure databases

ProteinModelPortaliA0LLR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiTWRRCLD.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LLR3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPYDATKMMD WQISEEAEKD MPSPWQWQEK LGLLKEEILP MGRLCKLDFL
60 70 80 90 100
KIMNRLKDKP DGKYIEVTAI TPTPLGEGKS TTSVGLMEGL GKRGVNVGGC
110 120 130 140 150
LRQPSGGPTM NIKGTAAGGG NALLIPMTEF SMGLTGDIND IMNAHNLAMV
160 170 180 190 200
ALTARMQHER NYTDEQLDRL TKMRRLHIDP TRVEMGWIMD FCAQALRNII
210 220 230 240 250
IGIGGRQDGY MMQSKFGIAV SSELMAILSI VKDLPDLRKR LNEITVAFDR
260 270 280 290 300
RGNPVTTGDL EVGGAMTAFM RNTINPTLMC TAEYQPCMVH AGPFANIAVG
310 320 330 340 350
QSSIIADRIG LKMFDYHVTE SGFAADIGFE KFWNVKCRYS GLKPHVSVLT
360 370 380 390 400
TTIRALKMHG GGPKVVAGLA MPEEYTKENL KLLEKGIVNM VHHINTIRKS
410 420 430 440 450
GMNPVVCINA FHTDTKDEIA LVRKHAEAAG ARCALSEHWA KGGEGALEFA
460 470 480 490 500
DAVIDACKQE SQFKFLYPLE MKLRDRVSTV AREVYGADGV SWTPDAEAKA
510 520 530 540 550
KMLENDPKYD DYATMMVKTH LSLTHDPSVK GVPKGWVLPI RDVLIYSGAK
560 570 580
FLCPCAGTIS LMPGTSSNPA FRRIDVDVNT GKVKGLF
Length:587
Mass (Da):64,624
Last modified:December 12, 2006 - v1
Checksum:i174E693ECDA3007E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000478 Genomic DNA. Translation: ABK18365.1.
RefSeqiWP_011699532.1. NC_008554.1.
YP_846800.1. NC_008554.1.

Genome annotation databases

EnsemblBacteriaiABK18365; ABK18365; Sfum_2687.
GeneIDi4458986.
KEGGisfu:Sfum_2687.
PATRICi23851269. VBISynFum78438_3195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000478 Genomic DNA. Translation: ABK18365.1 .
RefSeqi WP_011699532.1. NC_008554.1.
YP_846800.1. NC_008554.1.

3D structure databases

ProteinModelPortali A0LLR3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335543.Sfum_2687.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK18365 ; ABK18365 ; Sfum_2687 .
GeneIDi 4458986.
KEGGi sfu:Sfum_2687.
PATRICi 23851269. VBISynFum78438_3195.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi TWRRCLD.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SFUM335543:GH6P-2735-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10017 / MPOB.

Entry informationi

Entry nameiFTHS_SYNFM
AccessioniPrimary (citable) accession number: A0LLR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3