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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei587ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSFUM335543:G1G7I-2158-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Sfum_2084
OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Taxonomic identifieri335543 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
Proteomesi
  • UP000001784 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000094541 – 829Leucine--tRNA ligaseAdd BLAST829

Proteomic databases

PRIDEiA0LK15

Interactioni

Protein-protein interaction databases

STRINGi335543.Sfum_2084

Structurei

3D structure databases

ProteinModelPortaliA0LK15
SMRiA0LK15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi584 – 588"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0LK15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYKYAPKRI EKKWQEHWER EKLFEVSEIP GREKFYLLEM FPYPSGRIHM
60 70 80 90 100
GHVRNYSIGD VVARFLRMRG YNVLHPMGWD AFGMPAENAA IKAKTHPARW
110 120 130 140 150
TYENIAYMRS QLKQLGFSYD WSREFATCDV SYYRWEQLFF LKMYEKGLAY
160 170 180 190 200
KRSAYVNWCG TCLTVLANEQ VEGGACWRCD QPVVQKEMEQ WFFKITDYVE
210 220 230 240 250
ELLDYTHRLP GWPERVLTMQ QNWIGKSLGS KLLFPLASGD GSITVFTTRA
260 270 280 290 300
DTLFGATFMS LAPEHPLVEG LCRGNPQESE VLRFVQAAKQ AKRNDREAEL
310 320 330 340 350
LEKEGVFTGS CCINPVTGAK MPIYVANFVV MEYGTGAVMA VPAHDQRDFE
360 370 380 390 400
FARKYGLPVK VVIKPADAAA APAAQELSAA FEDDGVLVDS GAYSGMASAE
410 420 430 440 450
ARTAITADLA GKGLGEQTVQ YRLRDWGISR QRYWGAPIPI VYCDKCGTVP
460 470 480 490 500
VPEKDLPVVL PTDVALLPNG ASPLPAHAPF LNTDCPRCGG PARRETDTMD
510 520 530 540 550
TFVESSWYFA RFACARYDQG PLDLPKVKYW MPVDQYIGGI EHAVLHLLYS
560 570 580 590 600
RFFVKVLRDM GALEVDEPFR NLLTQGMVIK DGAKMSKSKG NVVDPDDMIK
610 620 630 640 650
AYGADTVRLF CLFASPPEKD LEWSDQGVEG SFRFLSRIWR LVSDNLDALR
660 670 680 690 700
SAPRHNGGGA LPEPLEALHR KTHQTIKKVT EDIRDRFHFN TAIAAIMELV
710 720 730 740 750
NQIYQVVEGG SRAGNIWPVV KEAVEALILL VSPMAPHIAE EIWHELGHTR
760 770 780 790 800
SVLLEPWPEW SGKALQAEEV MLVVQVNGRL RSRITVPSDA TPEQMEAAAL
810 820
ADSRVQEFIA GKPVRKVVVV PKKIINVVV
Length:829
Mass (Da):93,354
Last modified:December 12, 2006 - v1
Checksum:i5AA680E8AE916D5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000478 Genomic DNA Translation: ABK17767.1
RefSeqiWP_011698936.1, NC_008554.1

Genome annotation databases

EnsemblBacteriaiABK17767; ABK17767; Sfum_2084
KEGGisfu:Sfum_2084

Similar proteinsi

Entry informationi

Entry nameiSYL_SYNFM
AccessioniPrimary (citable) accession number: A0LK15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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