SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A0LK15

- SYL_SYNFM

UniProt

A0LK15 - SYL_SYNFM

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene
leuS, Sfum_2084
Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei587 – 5871ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSFUM335543:GH6P-2122-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Sfum_2084
OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Taxonomic identifieri335543 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
ProteomesiUP000001784: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Leucine--tRNA ligaseUniRule annotationPRO_1000009454Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335543.Sfum_2084.

Structurei

3D structure databases

ProteinModelPortaliA0LK15.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi584 – 5885"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0LK15-1 [UniParc]FASTAAdd to Basket

« Hide

MDYKYAPKRI EKKWQEHWER EKLFEVSEIP GREKFYLLEM FPYPSGRIHM    50
GHVRNYSIGD VVARFLRMRG YNVLHPMGWD AFGMPAENAA IKAKTHPARW 100
TYENIAYMRS QLKQLGFSYD WSREFATCDV SYYRWEQLFF LKMYEKGLAY 150
KRSAYVNWCG TCLTVLANEQ VEGGACWRCD QPVVQKEMEQ WFFKITDYVE 200
ELLDYTHRLP GWPERVLTMQ QNWIGKSLGS KLLFPLASGD GSITVFTTRA 250
DTLFGATFMS LAPEHPLVEG LCRGNPQESE VLRFVQAAKQ AKRNDREAEL 300
LEKEGVFTGS CCINPVTGAK MPIYVANFVV MEYGTGAVMA VPAHDQRDFE 350
FARKYGLPVK VVIKPADAAA APAAQELSAA FEDDGVLVDS GAYSGMASAE 400
ARTAITADLA GKGLGEQTVQ YRLRDWGISR QRYWGAPIPI VYCDKCGTVP 450
VPEKDLPVVL PTDVALLPNG ASPLPAHAPF LNTDCPRCGG PARRETDTMD 500
TFVESSWYFA RFACARYDQG PLDLPKVKYW MPVDQYIGGI EHAVLHLLYS 550
RFFVKVLRDM GALEVDEPFR NLLTQGMVIK DGAKMSKSKG NVVDPDDMIK 600
AYGADTVRLF CLFASPPEKD LEWSDQGVEG SFRFLSRIWR LVSDNLDALR 650
SAPRHNGGGA LPEPLEALHR KTHQTIKKVT EDIRDRFHFN TAIAAIMELV 700
NQIYQVVEGG SRAGNIWPVV KEAVEALILL VSPMAPHIAE EIWHELGHTR 750
SVLLEPWPEW SGKALQAEEV MLVVQVNGRL RSRITVPSDA TPEQMEAAAL 800
ADSRVQEFIA GKPVRKVVVV PKKIINVVV 829
Length:829
Mass (Da):93,354
Last modified:December 12, 2006 - v1
Checksum:i5AA680E8AE916D5A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000478 Genomic DNA. Translation: ABK17767.1.
RefSeqiWP_011698936.1. NC_008554.1.
YP_846202.1. NC_008554.1.

Genome annotation databases

EnsemblBacteriaiABK17767; ABK17767; Sfum_2084.
GeneIDi4459613.
KEGGisfu:Sfum_2084.
PATRICi23849777. VBISynFum78438_2458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000478 Genomic DNA. Translation: ABK17767.1 .
RefSeqi WP_011698936.1. NC_008554.1.
YP_846202.1. NC_008554.1.

3D structure databases

ProteinModelPortali A0LK15.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335543.Sfum_2084.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK17767 ; ABK17767 ; Sfum_2084 .
GeneIDi 4459613.
KEGGi sfu:Sfum_2084.
PATRICi 23849777. VBISynFum78438_2458.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SFUM335543:GH6P-2122-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10017 / MPOB.

Entry informationi

Entry nameiSYL_SYNFM
AccessioniPrimary (citable) accession number: A0LK15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi