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A0LJL8

- NUON2_SYNFM

UniProt

A0LJL8 - NUON2_SYNFM

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Protein
NADH-quinone oxidoreductase subunit N 2
Gene
nuoN2, Sfum_1935
Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciSFUM335543:GH6P-1972-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit N 2 (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit N 2
NDH-1 subunit N 2
Gene namesi
Name:nuoN2
Ordered Locus Names:Sfum_1935
OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Taxonomic identifieri335543 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
ProteomesiUP000001784: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321Helical; Reviewed prediction
Add
BLAST
Transmembranei34 – 5421Helical; Reviewed prediction
Add
BLAST
Transmembranei67 – 8721Helical; Reviewed prediction
Add
BLAST
Transmembranei106 – 12621Helical; Reviewed prediction
Add
BLAST
Transmembranei156 – 17621Helical; Reviewed prediction
Add
BLAST
Transmembranei198 – 21821Helical; Reviewed prediction
Add
BLAST
Transmembranei233 – 25321Helical; Reviewed prediction
Add
BLAST
Transmembranei263 – 28321Helical; Reviewed prediction
Add
BLAST
Transmembranei291 – 31121Helical; Reviewed prediction
Add
BLAST
Transmembranei317 – 33721Helical; Reviewed prediction
Add
BLAST
Transmembranei360 – 38021Helical; Reviewed prediction
Add
BLAST
Transmembranei398 – 41821Helical; Reviewed prediction
Add
BLAST
Transmembranei441 – 46121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472NADH-quinone oxidoreductase subunit N 2UniRule annotation
PRO_5000166272Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Protein-protein interaction databases

STRINGi335543.Sfum_1935.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1007.
HOGENOMiHOG000100794.
KOiK00343.
OMAiVFTTAFP.
OrthoDBiEOG64JFNZ.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LJL8-1 [UniParc]FASTAAdd to Basket

« Hide

MNWMSFAPEL ITLTSALWFL LLSMTARSDP KREHVAALVL SALGLAACLA    50
SVGAEGYCFA GAYKVDLFSQ VFKVLLAAGL FLIVTLCGEL SDIEERNRRE 100
FYVLLFVCTL AMMLLVGANH FLVVFISLEL SSYSLYVLVA LRRDRGLGLE 150
AGIKYFLVGI FASGVMIFGL ALLYGASGIA ALDGMARVLP GIIHQPAVVI 200
GLLLTLSGFF FKLAVFPFHF WAPDAYQGAA NQVSAYIATA SKVAAIGVLV 250
RVIASAGDGG TYLVHVLAVL SVVSMTVGNL AAIAQQDLKR LLAYSTVAHA 300
GYVLIGVLSM NPAGYSAAVF YAFALLVMKF TAFLVLVEVA SDGGNLRVEE 350
LAGLHRRSPI LALALMVSLF SLAGIPPTVG FTGKFLVFVA AMGEGHFTLV 400
LIAMINVVIS LYYYLLVIKA AYLLEPRQEL PALRVSPPLK LLSGVLVIAM 450
VAAGFFPNQI IRVAESAAKA LL 472
Length:472
Mass (Da):50,331
Last modified:December 12, 2006 - v1
Checksum:iA9F7BBF6C1DCCD73
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000478 Genomic DNA. Translation: ABK17620.1.
RefSeqiYP_846055.1. NC_008554.1.

Genome annotation databases

EnsemblBacteriaiABK17620; ABK17620; Sfum_1935.
GeneIDi4459740.
KEGGisfu:Sfum_1935.
PATRICi23849405. VBISynFum78438_2273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000478 Genomic DNA. Translation: ABK17620.1 .
RefSeqi YP_846055.1. NC_008554.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335543.Sfum_1935.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK17620 ; ABK17620 ; Sfum_1935 .
GeneIDi 4459740.
KEGGi sfu:Sfum_1935.
PATRICi 23849405. VBISynFum78438_2273.

Phylogenomic databases

eggNOGi COG1007.
HOGENOMi HOG000100794.
KOi K00343.
OMAi VFTTAFP.
OrthoDBi EOG64JFNZ.

Enzyme and pathway databases

BioCyci SFUM335543:GH6P-1972-MONOMER.

Family and domain databases

HAMAPi MF_00445. NDH1_NuoN_1.
InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10017 / MPOB.

Entry informationi

Entry nameiNUON2_SYNFM
AccessioniPrimary (citable) accession number: A0LJL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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