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A0LIN6 (PDXA_SYNFM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxythreonine-4-phosphate dehydrogenase

EC=1.1.1.262
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene names
Name:pdxA
Ordered Locus Names:Sfum_1601
OrganismSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB) [Complete proteome] [HAMAP]
Taxonomic identifier335543 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity. HAMAP-Rule MF_00536

Catalytic activity

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. HAMAP-Rule MF_00536

Cofactor

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. HAMAP-Rule MF_00536

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00536

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00536.

Miscellaneous

The active site is located at the dimer interface By similarity.

Sequence similarities

Belongs to the PdxA family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3453454-hydroxythreonine-4-phosphate dehydrogenase HAMAP-Rule MF_00536
PRO_1000051520

Sites

Metal binding1731Divalent metal cation; shared with dimeric partner By similarity
Metal binding2181Divalent metal cation; shared with dimeric partner By similarity
Metal binding2741Divalent metal cation; shared with dimeric partner By similarity
Binding site1431Substrate By similarity
Binding site1441Substrate By similarity
Binding site2821Substrate By similarity
Binding site2911Substrate By similarity
Binding site3001Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A0LIN6 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 030A0107EA02ED92

FASTA34536,533
        10         20         30         40         50         60 
MSSSKPRIAL TMGDPCGVGP DVIAQALASP TLFECCTPIV VGDPSALQRS MALSGASKKV 

        70         80         90        100        110        120 
LVLREPAELP DDPGSDRIPL IAPVELSGRD IEHGRPTAAT CGAVVRYIES AVAFALAGQV 

       130        140        150        160        170        180 
RGVCTGPINK ARMHEHGFDF PGHTEFLQAL TGSRRVVMML AGPRLRVSLA TIHEALADVP 

       190        200        210        220        230        240 
ALLNVEMLRE VIRITAEALI RDFGLQAPRL AVAGLNPHAG EEGRFGREEI EILRPAIESL 

       250        260        270        280        290        300 
RPPGRCTVTG PYPADTLFQR AHAGEFDAVV AMYHDQGLVP IKLVHFYDAV NVSLGLPIVR 

       310        320        330        340 
TSVDHGTAYD LAGTGRAHPG SLTAAVQLAA LMAHNRFAAV SPVVP 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000478 Genomic DNA. Translation: ABK17288.1.
RefSeqYP_845723.1. NC_008554.1.

3D structure databases

ProteinModelPortalA0LIN6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING335543.Sfum_1601.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK17288; ABK17288; Sfum_1601.
GeneID4460101.
KEGGsfu:Sfum_1601.
PATRIC23848593. VBISynFum78438_1870.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1995.
HOGENOMHOG000221592.
KOK00097.
OMANLRVFFL.
OrthoDBEOG6GN6ZC.

Enzyme and pathway databases

BioCycSFUM335543:GH6P-1632-MONOMER.
UniPathwayUPA00244; UER00312.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
HAMAPMF_00536. PdxA.
InterProIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00557. pdxA. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDXA_SYNFM
AccessionPrimary (citable) accession number: A0LIN6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways