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A0LIL1

- KAD_SYNFM

UniProt

A0LIL1 - KAD_SYNFM

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Protein

Adenylate kinase

Gene
adk, Sfum_1576
Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism By similarity.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311AMP By similarity
Binding sitei36 – 361AMP By similarity
Binding sitei92 – 921AMP By similarity
Binding sitei127 – 1271ATP By similarity
Metal bindingi130 – 1301Zinc; structural By similarity
Metal bindingi133 – 1331Zinc; structural By similarity
Metal bindingi150 – 1501Zinc; structural By similarity
Metal bindingi153 – 1531Zinc; structural By similarity
Binding sitei160 – 1601AMP By similarity
Binding sitei171 – 1711AMP By similarity
Binding sitei199 – 1991ATP; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156ATP By similarity
Nucleotide bindingi57 – 593AMP By similarity
Nucleotide bindingi85 – 884AMP By similarity

GO - Molecular functioni

  1. adenylate kinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. AMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSFUM335543:GH6P-1607-MONOMER.
UniPathwayiUPA00588; UER00649.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase (EC:2.7.4.3)
Short name:
AK
Alternative name(s):
ATP-AMP transphosphorylase
ATP:AMP phosphotransferase
Adenylate monophosphate kinase
Gene namesi
Name:adk
Ordered Locus Names:Sfum_1576
OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Taxonomic identifieri335543 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
ProteomesiUP000001784: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Adenylate kinaseUniRule annotationPRO_1000021776Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi335543.Sfum_1576.

Structurei

3D structure databases

ProteinModelPortaliA0LIL1.
SMRiA0LIL1. Positions 1-212.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 5930NMPbind By similarityAdd
BLAST
Regioni126 – 16338LID By similarityAdd
BLAST

Domaini

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the adenylate kinase family.

Phylogenomic databases

eggNOGiCOG0563.
HOGENOMiHOG000238772.
KOiK00939.
OMAiLMKSCID.
OrthoDBiEOG679TH4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00235. Adenylate_kinase_Adk.
InterProiIPR006259. Adenyl_kin_sub.
IPR000850. Adenylat/UMP-CMP_kin.
IPR007862. Adenylate_kinase_lid-dom.
IPR027417. P-loop_NTPase.
IPR001878. Znf_CCHC.
[Graphical view]
PANTHERiPTHR23359. PTHR23359. 1 hit.
PfamiPF05191. ADK_lid. 1 hit.
[Graphical view]
PRINTSiPR00094. ADENYLTKNASE.
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01351. adk. 1 hit.
PROSITEiPS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0LIL1-1 [UniParc]FASTAAdd to Basket

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MNIILLGPPG AGKGTQASRL IGKYAIPQIS TGDMLRAALK EGTPLGLEAK    50
KYMDQGALVP DSVVIGLVKE RIQKPDCSKG YMLDGFPRNV SQAEALDMML 100
GELKQRIDGV VCIEVPNKEL LGRLTGRRTC RSCGAGFHVM FDPPKTDGKC 150
DKCGGELYQR DDDNEATVSS RLKVYEDQTK PLIDYYEKQG KLRRIDGVGS 200
MDAIFGRITA ILG 213
Length:213
Mass (Da):23,226
Last modified:December 12, 2006 - v1
Checksum:i455B36B689579F3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000478 Genomic DNA. Translation: ABK17263.1.
RefSeqiYP_845698.1. NC_008554.1.

Genome annotation databases

EnsemblBacteriaiABK17263; ABK17263; Sfum_1576.
GeneIDi4460146.
KEGGisfu:Sfum_1576.
PATRICi23848531. VBISynFum78438_1839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000478 Genomic DNA. Translation: ABK17263.1 .
RefSeqi YP_845698.1. NC_008554.1.

3D structure databases

ProteinModelPortali A0LIL1.
SMRi A0LIL1. Positions 1-212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335543.Sfum_1576.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK17263 ; ABK17263 ; Sfum_1576 .
GeneIDi 4460146.
KEGGi sfu:Sfum_1576.
PATRICi 23848531. VBISynFum78438_1839.

Phylogenomic databases

eggNOGi COG0563.
HOGENOMi HOG000238772.
KOi K00939.
OMAi LMKSCID.
OrthoDBi EOG679TH4.

Enzyme and pathway databases

UniPathwayi UPA00588 ; UER00649 .
BioCyci SFUM335543:GH6P-1607-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00235. Adenylate_kinase_Adk.
InterProi IPR006259. Adenyl_kin_sub.
IPR000850. Adenylat/UMP-CMP_kin.
IPR007862. Adenylate_kinase_lid-dom.
IPR027417. P-loop_NTPase.
IPR001878. Znf_CCHC.
[Graphical view ]
PANTHERi PTHR23359. PTHR23359. 1 hit.
Pfami PF05191. ADK_lid. 1 hit.
[Graphical view ]
PRINTSi PR00094. ADENYLTKNASE.
SMARTi SM00343. ZnF_C2HC. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01351. adk. 1 hit.
PROSITEi PS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10017 / MPOB.

Entry informationi

Entry nameiKAD_SYNFM
AccessioniPrimary (citable) accession number: A0LIL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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