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A0LG71

- UPPP_SYNFM

UniProt

A0LG71 - UPPP_SYNFM

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSFUM335543:GH6P-742-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Sfum_0725
    OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
    Taxonomic identifieri335543 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
    ProteomesiUP000001784: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281Undecaprenyl-diphosphatasePRO_0000290776Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi335543.Sfum_0725.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei45 – 6521HelicalUniRule annotationAdd
    BLAST
    Transmembranei93 – 11321HelicalUniRule annotationAdd
    BLAST
    Transmembranei125 – 14521HelicalUniRule annotationAdd
    BLAST
    Transmembranei155 – 17521HelicalUniRule annotationAdd
    BLAST
    Transmembranei195 – 21521HelicalUniRule annotationAdd
    BLAST
    Transmembranei227 – 24721HelicalUniRule annotationAdd
    BLAST
    Transmembranei256 – 27621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiMEIGTIF.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0LG71-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVLQGLLLG LIQGLTEFLP ISSTAHLTLA GKWMGVVSAE HPEHWTAFIA    50
    VIQLGTMAAV LIYFARDVLD ISLTFLEENV FRRMRFKDQS HVSKLGWYVI 100
    LGSLPVATFG LVFKKVIEGS LTKSLIVISA SLIVFGILLG VSEVVARFSK 150
    SIKRISWLDA LVVGFAQVMA LVPGASRSGT TITAGLFMGM TRETAARFSF 200
    LLSIPAVMAS GLLEFRESLD FMGSQDFLVL ASATLMSAVS GYLTIAFLLR 250
    FLRRHSTNVF VVYRVVLGGA LLWMVFRHGV V 281
    Length:281
    Mass (Da):30,725
    Last modified:December 12, 2006 - v1
    Checksum:iB311D3F57C17F326
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000478 Genomic DNA. Translation: ABK16423.1.
    RefSeqiYP_844858.1. NC_008554.1.

    Genome annotation databases

    EnsemblBacteriaiABK16423; ABK16423; Sfum_0725.
    GeneIDi4460791.
    KEGGisfu:Sfum_0725.
    PATRICi23846509. VBISynFum78438_0844.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000478 Genomic DNA. Translation: ABK16423.1 .
    RefSeqi YP_844858.1. NC_008554.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335543.Sfum_0725.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK16423 ; ABK16423 ; Sfum_0725 .
    GeneIDi 4460791.
    KEGGi sfu:Sfum_0725.
    PATRICi 23846509. VBISynFum78438_0844.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi MEIGTIF.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci SFUM335543:GH6P-742-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 10017 / MPOB.

    Entry informationi

    Entry nameiUPPP_SYNFM
    AccessioniPrimary (citable) accession number: A0LG71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3