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A0LG64

- NADK_SYNFM

UniProt

A0LG64 - NADK_SYNFM

Protein

NAD kinase

Gene

nadK

Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei66 – 661Proton acceptorUniRule annotation
    Binding sitei151 – 1511NADUniRule annotation
    Binding sitei168 – 1681NADUniRule annotation
    Binding sitei170 – 1701NADUniRule annotation
    Binding sitei240 – 2401NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi66 – 672NADUniRule annotation
    Nucleotide bindingi140 – 1412NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSFUM335543:GH6P-735-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Sfum_0718
    OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
    Taxonomic identifieri335543 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
    ProteomesiUP000001784: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283NAD kinasePRO_1000079526Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi335543.Sfum_0718.

    Structurei

    3D structure databases

    ProteinModelPortaliA0LG64.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiPRKTKFV.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0LG64-1 [UniParc]FASTAAdd to Basket

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    MRHIAVVYKR MRPEAARLAQ DIKSWLAKRN VLVFCMENID SAGVLSSHQR    50
    VDFPQDTDLV IVLGGDGTLL SVARLIESRK IPVIGVNLGG MGFLTGITID 100
    NCYMELERIL GGDYEIEERM RLRVLVRREH REIFSHRVLN DAVINKGALA 150
    RIIDLVTVID GRFLTHYRGD GLIFSTPTGS TAYNLAAGGP IVFPTAQAII 200
    ITPICSFTLT NRPIIFPSHV IIRIELGEPI KDVTLTCDGQ VGCLLAPSDR 250
    IVITAAANPL RLIKTPTVDH FEILRNKLKW GQA 283
    Length:283
    Mass (Da):31,373
    Last modified:December 12, 2006 - v1
    Checksum:i3FB1535E21F60D52
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000478 Genomic DNA. Translation: ABK16416.1.
    RefSeqiYP_844851.1. NC_008554.1.

    Genome annotation databases

    EnsemblBacteriaiABK16416; ABK16416; Sfum_0718.
    GeneIDi4460784.
    KEGGisfu:Sfum_0718.
    PATRICi23846495. VBISynFum78438_0837.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000478 Genomic DNA. Translation: ABK16416.1 .
    RefSeqi YP_844851.1. NC_008554.1.

    3D structure databases

    ProteinModelPortali A0LG64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335543.Sfum_0718.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK16416 ; ABK16416 ; Sfum_0718 .
    GeneIDi 4460784.
    KEGGi sfu:Sfum_0718.
    PATRICi 23846495. VBISynFum78438_0837.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi PRKTKFV.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci SFUM335543:GH6P-735-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 10017 / MPOB.

    Entry informationi

    Entry nameiNADK_SYNFM
    AccessioniPrimary (citable) accession number: A0LG64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3