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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K+UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (Sfum_0467)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (Sfum_0467)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100SubstrateUniRule annotation1
Active sitei109Proton acceptorUniRule annotation1
Metal bindingi129Monovalent cationUniRule annotation1
Binding sitei132ATPUniRule annotation1
Binding sitei185SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 13ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciSFUM335543:G1G7I-564-MONOMER
UniPathwayiUPA00241; UER00352

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaXUniRule annotation
Ordered Locus Names:Sfum_0549
OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Taxonomic identifieri335543 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
Proteomesi
  • UP000001784 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000544121 – 258Type III pantothenate kinaseAdd BLAST258

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi335543.Sfum_0549

Structurei

3D structure databases

ProteinModelPortaliA0LFP6
SMRiA0LFP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 110Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108194 Bacteria
COG1521 LUCA
HOGENOMiHOG000066025
KOiK03525
OMAiHEPWLTL
OrthoDBiPOG091H01V7

Family and domain databases

HAMAPiMF_01274 Pantothen_kinase_3, 1 hit
InterProiView protein in InterPro
IPR004619 Type_III_PanK
PANTHERiPTHR34265 PTHR34265, 1 hit
PfamiView protein in Pfam
PF03309 Pan_kinase, 1 hit
TIGRFAMsiTIGR00671 baf, 1 hit

Sequencei

Sequence statusi: Complete.

A0LFP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAMDIGNT NTVLGLFNEQ RLVHDWRIRT EVNTTVDEYG IAIRSLFDAH
60 70 80 90 100
GFFVADVGSV IISCVVPPVL NSIERFCRKY FNIQPIIVGP GIRTGMPIFY
110 120 130 140 150
DNPKEVGADR IVNAVAAYDY YRCATIVVDF GTATTFDYIS DKGEYMGGVI
160 170 180 190 200
SPGIMISCEA LFFKTSKLPR VEIFARPPSV LAKNTIASMN AGIVYGYAGL
210 220 230 240 250
VEGIITRMRN EIGTNLKVVA TGGLAALIAS ECSLIDDVDD YLTLKGLRII

FERNKKNP
Length:258
Mass (Da):28,367
Last modified:December 12, 2006 - v1
Checksum:i48EC78C9FB91DD1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000478 Genomic DNA Translation: ABK16248.1
RefSeqiWP_011697421.1, NC_008554.1

Genome annotation databases

EnsemblBacteriaiABK16248; ABK16248; Sfum_0549
KEGGisfu:Sfum_0549

Similar proteinsi

Entry informationi

Entry nameiCOAX_SYNFM
AccessioniPrimary (citable) accession number: A0LFP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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