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Protein

NADH-quinone oxidoreductase subunit N 1

Gene

nuoN1

Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciSFUM335543:GH6P-214-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit N 1UniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit N 1UniRule annotation
NDH-1 subunit N 1UniRule annotation
Gene namesi
Name:nuoN1UniRule annotation
Ordered Locus Names:Sfum_0209
OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Taxonomic identifieri335543 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
ProteomesiUP000001784 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalUniRule annotationAdd
BLAST
Transmembranei33 – 5321HelicalUniRule annotationAdd
BLAST
Transmembranei66 – 8621HelicalUniRule annotationAdd
BLAST
Transmembranei102 – 12221HelicalUniRule annotationAdd
BLAST
Transmembranei157 – 17721HelicalUniRule annotationAdd
BLAST
Transmembranei199 – 21921HelicalUniRule annotationAdd
BLAST
Transmembranei226 – 24823HelicalUniRule annotationAdd
BLAST
Transmembranei265 – 28521HelicalUniRule annotationAdd
BLAST
Transmembranei292 – 31221HelicalUniRule annotationAdd
BLAST
Transmembranei318 – 33821HelicalUniRule annotationAdd
BLAST
Transmembranei362 – 38221HelicalUniRule annotationAdd
BLAST
Transmembranei399 – 41921HelicalUniRule annotationAdd
BLAST
Transmembranei445 – 46521HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473NADH-quinone oxidoreductase subunit N 1PRO_0000391237Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi335543.Sfum_0209.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1007.
HOGENOMiHOG000100795.
KOiK00343.
OMAiIATASKM.
OrthoDBiEOG6J48M3.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LEQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKWVLFIPE LYYLLMAVVF FACSLSRRLQ SGVLYRWAVI LAGGGLLATV
60 70 80 90 100
LAVNQNGFIF FDCYRVDLYS QLFKILLALG TFWVIFSCSE LQGIDSRYHA
110 120 130 140 150
EFFLLTTVCT LGMMMLVSAN ELLTVYVSIE LSSYSLYLLV PMRKQTEIYV
160 170 180 190 200
ETGIKYFMIG VTASAFMLFG ISFIFGVAHT TYVPDLVKTL PSLIKEPAAI
210 220 230 240 250
IGLVLTLCGF FFKQALFPFH SWAPDVYMGA ANQVTTYIAT ASKMAAAAMV
260 270 280 290 300
IRFVNLSGGE SPLFTQVLVG LAVLSMTFGN LVAIIQKDLK RLLAYSSIAH
310 320 330 340 350
AGYMMIGILT MSEHGVASAI YYSAAYLVMN FACFMVIMKV ADDGRNLQIK
360 370 380 390 400
ELAGLHKRSP LLAMTLMLGL FGLAGIPPTV GFTGKFLVFA AALRKGYLIL
410 420 430 440 450
VIIGMINATI SLYYYLIVIK AAYLLEPERP YPDVRVDTWT RALSYGLIVL
460 470
MIYLGVFPDQ FVALTEAAAR SLP
Length:473
Mass (Da):52,334
Last modified:December 12, 2006 - v1
Checksum:i761B65B42450C1A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000478 Genomic DNA. Translation: ABK15910.1.
RefSeqiWP_011697083.1. NC_008554.1.

Genome annotation databases

EnsemblBacteriaiABK15910; ABK15910; Sfum_0209.
KEGGisfu:Sfum_0209.
PATRICi23845281. VBISynFum78438_0241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000478 Genomic DNA. Translation: ABK15910.1.
RefSeqiWP_011697083.1. NC_008554.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi335543.Sfum_0209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK15910; ABK15910; Sfum_0209.
KEGGisfu:Sfum_0209.
PATRICi23845281. VBISynFum78438_0241.

Phylogenomic databases

eggNOGiCOG1007.
HOGENOMiHOG000100795.
KOiK00343.
OMAiIATASKM.
OrthoDBiEOG6J48M3.

Enzyme and pathway databases

BioCyciSFUM335543:GH6P-214-MONOMER.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10017 / MPOB.

Entry informationi

Entry nameiNUON1_SYNFM
AccessioniPrimary (citable) accession number: A0LEQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: December 12, 2006
Last modified: July 22, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.