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A0LEQ8 (NUON1_SYNFM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit N 1

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit N 1
NDH-1 subunit N 1
Gene names
Name:nuoN1
Ordered Locus Names:Sfum_0209
OrganismSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB) [Complete proteome] [HAMAP]
Taxonomic identifier335543 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_00445

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_00445

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00445.

Sequence similarities

Belongs to the complex I subunit 2 family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processATP synthesis coupled electron transport

Inferred from electronic annotation. Source: InterPro

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 473473NADH-quinone oxidoreductase subunit N 1 HAMAP-Rule MF_00445
PRO_0000391237

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane33 – 5321Helical; Potential
Transmembrane66 – 8621Helical; Potential
Transmembrane102 – 12221Helical; Potential
Transmembrane157 – 17721Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane226 – 24823Helical; Potential
Transmembrane265 – 28521Helical; Potential
Transmembrane292 – 31221Helical; Potential
Transmembrane318 – 33821Helical; Potential
Transmembrane362 – 38221Helical; Potential
Transmembrane399 – 41921Helical; Potential
Transmembrane445 – 46521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A0LEQ8 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 761B65B42450C1A0

FASTA47352,334
        10         20         30         40         50         60 
MMKWVLFIPE LYYLLMAVVF FACSLSRRLQ SGVLYRWAVI LAGGGLLATV LAVNQNGFIF 

        70         80         90        100        110        120 
FDCYRVDLYS QLFKILLALG TFWVIFSCSE LQGIDSRYHA EFFLLTTVCT LGMMMLVSAN 

       130        140        150        160        170        180 
ELLTVYVSIE LSSYSLYLLV PMRKQTEIYV ETGIKYFMIG VTASAFMLFG ISFIFGVAHT 

       190        200        210        220        230        240 
TYVPDLVKTL PSLIKEPAAI IGLVLTLCGF FFKQALFPFH SWAPDVYMGA ANQVTTYIAT 

       250        260        270        280        290        300 
ASKMAAAAMV IRFVNLSGGE SPLFTQVLVG LAVLSMTFGN LVAIIQKDLK RLLAYSSIAH 

       310        320        330        340        350        360 
AGYMMIGILT MSEHGVASAI YYSAAYLVMN FACFMVIMKV ADDGRNLQIK ELAGLHKRSP 

       370        380        390        400        410        420 
LLAMTLMLGL FGLAGIPPTV GFTGKFLVFA AALRKGYLIL VIIGMINATI SLYYYLIVIK 

       430        440        450        460        470 
AAYLLEPERP YPDVRVDTWT RALSYGLIVL MIYLGVFPDQ FVALTEAAAR SLP 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000478 Genomic DNA. Translation: ABK15910.1.
RefSeqYP_844345.1. NC_008554.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING335543.Sfum_0209.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK15910; ABK15910; Sfum_0209.
GeneID4461472.
KEGGsfu:Sfum_0209.
PATRIC23845281. VBISynFum78438_0241.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1007.
HOGENOMHOG000100795.
KOK00343.
OMAYEGASNE.
OrthoDBEOG6J48M3.

Enzyme and pathway databases

BioCycSFUM335543:GH6P-214-MONOMER.

Family and domain databases

HAMAPMF_00445. NDH1_NuoN_1.
InterProIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsTIGR01770. NDH_I_N. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNUON1_SYNFM
AccessionPrimary (citable) accession number: A0LEQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families