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A0LEQ8

- NUON1_SYNFM

UniProt

A0LEQ8 - NUON1_SYNFM

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Protein

NADH-quinone oxidoreductase subunit N 1

Gene
nuoN1, Sfum_0209
Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciSFUM335543:GH6P-214-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit N 1 (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit N 1
NDH-1 subunit N 1
Gene namesi
Name:nuoN1
Ordered Locus Names:Sfum_0209
OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Taxonomic identifieri335543 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
ProteomesiUP000001784: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Reviewed predictionAdd
BLAST
Transmembranei33 – 5321Helical; Reviewed predictionAdd
BLAST
Transmembranei66 – 8621Helical; Reviewed predictionAdd
BLAST
Transmembranei102 – 12221Helical; Reviewed predictionAdd
BLAST
Transmembranei157 – 17721Helical; Reviewed predictionAdd
BLAST
Transmembranei199 – 21921Helical; Reviewed predictionAdd
BLAST
Transmembranei226 – 24823Helical; Reviewed predictionAdd
BLAST
Transmembranei265 – 28521Helical; Reviewed predictionAdd
BLAST
Transmembranei292 – 31221Helical; Reviewed predictionAdd
BLAST
Transmembranei318 – 33821Helical; Reviewed predictionAdd
BLAST
Transmembranei362 – 38221Helical; Reviewed predictionAdd
BLAST
Transmembranei399 – 41921Helical; Reviewed predictionAdd
BLAST
Transmembranei445 – 46521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473NADH-quinone oxidoreductase subunit N 1UniRule annotationPRO_0000391237Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Protein-protein interaction databases

STRINGi335543.Sfum_0209.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1007.
HOGENOMiHOG000100795.
KOiK00343.
OMAiYEGASNE.
OrthoDBiEOG6J48M3.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LEQ8-1 [UniParc]FASTAAdd to Basket

« Hide

MMKWVLFIPE LYYLLMAVVF FACSLSRRLQ SGVLYRWAVI LAGGGLLATV    50
LAVNQNGFIF FDCYRVDLYS QLFKILLALG TFWVIFSCSE LQGIDSRYHA 100
EFFLLTTVCT LGMMMLVSAN ELLTVYVSIE LSSYSLYLLV PMRKQTEIYV 150
ETGIKYFMIG VTASAFMLFG ISFIFGVAHT TYVPDLVKTL PSLIKEPAAI 200
IGLVLTLCGF FFKQALFPFH SWAPDVYMGA ANQVTTYIAT ASKMAAAAMV 250
IRFVNLSGGE SPLFTQVLVG LAVLSMTFGN LVAIIQKDLK RLLAYSSIAH 300
AGYMMIGILT MSEHGVASAI YYSAAYLVMN FACFMVIMKV ADDGRNLQIK 350
ELAGLHKRSP LLAMTLMLGL FGLAGIPPTV GFTGKFLVFA AALRKGYLIL 400
VIIGMINATI SLYYYLIVIK AAYLLEPERP YPDVRVDTWT RALSYGLIVL 450
MIYLGVFPDQ FVALTEAAAR SLP 473
Length:473
Mass (Da):52,334
Last modified:December 12, 2006 - v1
Checksum:i761B65B42450C1A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000478 Genomic DNA. Translation: ABK15910.1.
RefSeqiWP_011697083.1. NC_008554.1.
YP_844345.1. NC_008554.1.

Genome annotation databases

EnsemblBacteriaiABK15910; ABK15910; Sfum_0209.
GeneIDi4461472.
KEGGisfu:Sfum_0209.
PATRICi23845281. VBISynFum78438_0241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000478 Genomic DNA. Translation: ABK15910.1 .
RefSeqi WP_011697083.1. NC_008554.1.
YP_844345.1. NC_008554.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335543.Sfum_0209.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK15910 ; ABK15910 ; Sfum_0209 .
GeneIDi 4461472.
KEGGi sfu:Sfum_0209.
PATRICi 23845281. VBISynFum78438_0241.

Phylogenomic databases

eggNOGi COG1007.
HOGENOMi HOG000100795.
KOi K00343.
OMAi YEGASNE.
OrthoDBi EOG6J48M3.

Enzyme and pathway databases

BioCyci SFUM335543:GH6P-214-MONOMER.

Family and domain databases

HAMAPi MF_00445. NDH1_NuoN_1.
InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10017 / MPOB.

Entry informationi

Entry nameiNUON1_SYNFM
AccessioniPrimary (citable) accession number: A0LEQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: December 12, 2006
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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