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A0LEQ8

- NUON1_SYNFM

UniProt

A0LEQ8 - NUON1_SYNFM

Protein

NADH-quinone oxidoreductase subunit N 1

Gene

nuoN1

Organism
Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciSFUM335543:GH6P-214-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit N 1UniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit N 1UniRule annotation
    NDH-1 subunit N 1UniRule annotation
    Gene namesi
    Name:nuoN1UniRule annotation
    Ordered Locus Names:Sfum_0209
    OrganismiSyntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
    Taxonomic identifieri335543 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophobacteraceaeSyntrophobacter
    ProteomesiUP000001784: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 473473NADH-quinone oxidoreductase subunit N 1PRO_0000391237Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi335543.Sfum_0209.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalUniRule annotationAdd
    BLAST
    Transmembranei33 – 5321HelicalUniRule annotationAdd
    BLAST
    Transmembranei66 – 8621HelicalUniRule annotationAdd
    BLAST
    Transmembranei102 – 12221HelicalUniRule annotationAdd
    BLAST
    Transmembranei157 – 17721HelicalUniRule annotationAdd
    BLAST
    Transmembranei199 – 21921HelicalUniRule annotationAdd
    BLAST
    Transmembranei226 – 24823HelicalUniRule annotationAdd
    BLAST
    Transmembranei265 – 28521HelicalUniRule annotationAdd
    BLAST
    Transmembranei292 – 31221HelicalUniRule annotationAdd
    BLAST
    Transmembranei318 – 33821HelicalUniRule annotationAdd
    BLAST
    Transmembranei362 – 38221HelicalUniRule annotationAdd
    BLAST
    Transmembranei399 – 41921HelicalUniRule annotationAdd
    BLAST
    Transmembranei445 – 46521HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 2 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1007.
    HOGENOMiHOG000100795.
    KOiK00343.
    OMAiYEGASNE.
    OrthoDBiEOG6J48M3.

    Family and domain databases

    HAMAPiMF_00445. NDH1_NuoN_1.
    InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0LEQ8-1 [UniParc]FASTAAdd to Basket

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    MMKWVLFIPE LYYLLMAVVF FACSLSRRLQ SGVLYRWAVI LAGGGLLATV    50
    LAVNQNGFIF FDCYRVDLYS QLFKILLALG TFWVIFSCSE LQGIDSRYHA 100
    EFFLLTTVCT LGMMMLVSAN ELLTVYVSIE LSSYSLYLLV PMRKQTEIYV 150
    ETGIKYFMIG VTASAFMLFG ISFIFGVAHT TYVPDLVKTL PSLIKEPAAI 200
    IGLVLTLCGF FFKQALFPFH SWAPDVYMGA ANQVTTYIAT ASKMAAAAMV 250
    IRFVNLSGGE SPLFTQVLVG LAVLSMTFGN LVAIIQKDLK RLLAYSSIAH 300
    AGYMMIGILT MSEHGVASAI YYSAAYLVMN FACFMVIMKV ADDGRNLQIK 350
    ELAGLHKRSP LLAMTLMLGL FGLAGIPPTV GFTGKFLVFA AALRKGYLIL 400
    VIIGMINATI SLYYYLIVIK AAYLLEPERP YPDVRVDTWT RALSYGLIVL 450
    MIYLGVFPDQ FVALTEAAAR SLP 473
    Length:473
    Mass (Da):52,334
    Last modified:December 12, 2006 - v1
    Checksum:i761B65B42450C1A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000478 Genomic DNA. Translation: ABK15910.1.
    RefSeqiWP_011697083.1. NC_008554.1.
    YP_844345.1. NC_008554.1.

    Genome annotation databases

    EnsemblBacteriaiABK15910; ABK15910; Sfum_0209.
    GeneIDi4461472.
    KEGGisfu:Sfum_0209.
    PATRICi23845281. VBISynFum78438_0241.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000478 Genomic DNA. Translation: ABK15910.1 .
    RefSeqi WP_011697083.1. NC_008554.1.
    YP_844345.1. NC_008554.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335543.Sfum_0209.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK15910 ; ABK15910 ; Sfum_0209 .
    GeneIDi 4461472.
    KEGGi sfu:Sfum_0209.
    PATRICi 23845281. VBISynFum78438_0241.

    Phylogenomic databases

    eggNOGi COG1007.
    HOGENOMi HOG000100795.
    KOi K00343.
    OMAi YEGASNE.
    OrthoDBi EOG6J48M3.

    Enzyme and pathway databases

    BioCyci SFUM335543:GH6P-214-MONOMER.

    Family and domain databases

    HAMAPi MF_00445. NDH1_NuoN_1.
    InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 10017 / MPOB.

    Entry informationi

    Entry nameiNUON1_SYNFM
    AccessioniPrimary (citable) accession number: A0LEQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 9, 2010
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3