A0LDT4 (CLPP_MAGSM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit
EC=3.4.21.92

Alternative name(s):
Endopeptidase Clp

Gene names

Name:	clpP
Ordered Locus Names:	Mmc1_3642

Organism

Magnetococcus sp. (strain MC-1) [Complete proteome] [HAMAP]

Taxonomic identifier

156889 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Magnetococcus

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	ATP-dependent Clp protease proteolytic subunit HAMAP MF_00444		PRO_1000135158
Sites
	Active site	98	1	By similarity
	Active site	123	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0LDT4 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: BCCE34CB2154D1F7	FASTA	202	22,281
	10 20 30 40 50 60 MSLVPMVVET TNRGERAYDI YSRLLKERVV FLVGQVEEHM ANLVVAQLLF LESENPEKDI 70 80 90 100 110 120 HLYINSPGGS VTAGMAIYDT MQFIRPSVST LCIGQAASMG AVLLAAGEAG KRLVLPNARV 130 140 150 160 170 180 MIHQPLGGFS GQASDFEIHA REILRIRENL NQVLSHHTGK PLEQVQLDTE RDNFLSATEA 190 200 VEYGLVDKVI SHRELPEAEA ES

References

[1]

"Complete sequence of Magnetococcus sp. MC-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Goodwin L.A., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000471 Genomic DNA. Translation: ABK46127.1.
RefSeq	YP_867533.1. NC_008576.1.
3D structure databases
ProteinModelPortal	A0LDT4.
SMR	A0LDT4. Positions 3-193.
ModBase	Search...
Protein-protein interaction databases
STRING	A0LDT4.
Protein family/group databases
MEROPS	S14.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4483829.
GenomeReviews	Gene locus Mmc1_3642 in contig CP000471_GR.
KEGG	mgm:Mmc1_3642.
NMPDR	fig|156889.1.peg.3647.
PATRIC	22434005. VBIMagSp23654_3725.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0740.
HOGENOM	HBG558421.
OMA	SHRELPE.
PhylomeDB	A0LDT4.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
TIGRFAMs	TIGR00493. ClpP. 1 hit.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CLPP_MAGSM

Accession

Primary (citable) accession number: A0LDT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program