Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A0LDR4 (NUON_MAGSM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit N

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit N
NDH-1 subunit N
Gene names
Name:nuoN
Ordered Locus Names:Mmc1_3622
OrganismMagnetococcus sp. (strain MC-1) [Complete proteome] [HAMAP]
Taxonomic identifier156889 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_00445

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_00445

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00445.

Sequence similarities

Belongs to the complex I subunit 2 family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processATP synthesis coupled electron transport

Inferred from electronic annotation. Source: InterPro

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483NADH-quinone oxidoreductase subunit N HAMAP-Rule MF_00445
PRO_0000391174

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane78 – 9821Helical; Potential
Transmembrane106 – 12621Helical; Potential
Transmembrane131 – 15121Helical; Potential
Transmembrane166 – 18621Helical; Potential
Transmembrane206 – 22621Helical; Potential
Transmembrane241 – 26121Helical; Potential
Transmembrane275 – 29521Helical; Potential
Transmembrane303 – 32321Helical; Potential
Transmembrane330 – 35021Helical; Potential
Transmembrane373 – 39321Helical; Potential
Transmembrane399 – 41921Helical; Potential
Transmembrane452 – 47221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A0LDR4 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 6D2C95DEA196F801

FASTA48351,796
        10         20         30         40         50         60 
MAIQMPDINL ALMLPEIVIS VVAMGLLLAS AWWEGAEGAR RIRRIAAGAL MVAMVITLLG 

        70         80         90        100        110        120 
VGATQSSTFG GMFVNDRFAA FMKVMLYLST LLPMVVSWVY LEKSKLGNGE YFVLTLFAML 

       130        140        150        160        170        180 
GGMFMISSGS FLVLYLGIEL LSLAIYVLAA YKRDDLASNE AGLKYFVLGS MASGILLYGI 

       190        200        210        220        230        240 
SLIYGVTGSV DFATINAYLQ QDHHSMLGIT MGLILVVSGL SFKIAAAPFH MWAPDVYEGA 

       250        260        270        280        290        300 
PTSVTAFMAA MPKIAAFAAL FRVLVEAFGP MHATWGPIMA LLAVVSMGVG ALAGLGQSNI 

       310        320        330        340        350        360 
KRLLAYSSIG HVGYALIGLA VGNQMGYEAV LVYLTIYIFM NVGAFGLILV LNKEGFGDQI 

       370        380        390        400        410        420 
EDYKGLSAKR PGLALLMAIF MFSMAGIPPL AGFMAKLQIF MAAIDAHMYT VAILGVLFSA 

       430        440        450        460        470        480 
VSAFYYLKVI KTMYFDEAER AFDMPMDFLS RAIVGVSGIL VVLWGILPGS LMASVAETIK 


SLM 

« Hide

References

[1]"Complete sequence of Magnetococcus sp. MC-1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Goodwin L.A., Brettin T., Bruce D., Han C., Tapia R., Gilna P. expand/collapse author list , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MC-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000471 Genomic DNA. Translation: ABK46107.1.
RefSeqYP_867513.1. NC_008576.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING156889.Mmc1_3622.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK46107; ABK46107; Mmc1_3622.
GeneID4480522.
KEGGmgm:Mmc1_3622.
PATRIC22433961. VBIMagSp23654_3705.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1007.
HOGENOMHOG000100795.
KOK00343.
OMAFQFMVSS.
OrthoDBEOG64JFNZ.

Enzyme and pathway databases

BioCycMSP156889:GH36-3670-MONOMER.

Family and domain databases

HAMAPMF_00445. NDH1_NuoN_1.
InterProIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsTIGR01770. NDH_I_N. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNUON_MAGSM
AccessionPrimary (citable) accession number: A0LDR4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: December 12, 2006
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families