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A0LDB0

- PUR9_MAGSM

UniProt

A0LDB0 - PUR9_MAGSM

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Mmc1_3468
Organism
Magnetococcus sp. (strain MC-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciMSP156889:GH36-3515-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Mmc1_3468
OrganismiMagnetococcus sp. (strain MC-1)
Taxonomic identifieri156889 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus
ProteomesiUP000002586: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000192978Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi156889.Mmc1_3468.

Structurei

3D structure databases

ProteinModelPortaliA0LDB0.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LDB0-1 [UniParc]FASTAAdd to Basket

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MAKIKRALIS VSDKTGLVPF CQGLAEHGVS FLSTGGTARL LRESGLDVMD    50
VSEFTGFPEM LDGRVKTLHP KVHGGLLGLR DNASHQQQMG EHGIEPIDMV 100
VVNLYPFEAT VAKEGCTLEE AIENIDIGGP SMLRSAAKNY RSVTVVTDPA 150
DYARVLESLR AHDGQCDAGL NAQLARKVYA RTAAYDAAIS NWLSALDNEG 200
RPGAFPETYT VQFKKVQGMR YGENPHQSAA FYAESPPSEE ASLATATQLQ 250
GKELSFNNIH DANGALELVK EFSKPAAVVV KHANPCGVAV HDGDLLAAYR 300
MARDTDPVSA FGGIIALNRC VDVAVAKEIA QLFVEVIIAP EYDEQALELF 350
ATKKNLRLLR VPNIGVATAV STMDLKRVTG GLLLQDRDLK QLPEGSLKVV 400
TERAPSEAEM RDLLFAWKVV KHVKSNAIVY AKEQRTLGVG AGQMSRVDAS 450
RIAVWKAQDT AHTAGLRENP LLGAAMASDA FFPFRDGVDA AAKAGAKAVI 500
QPGGSVRDEE VIAAANEHGM AMVFTGMRHF KH 532
Length:532
Mass (Da):57,270
Last modified:December 12, 2006 - v1
Checksum:i9B4C77A1369F150C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000471 Genomic DNA. Translation: ABK45953.1.
RefSeqiYP_867359.1. NC_008576.1.

Genome annotation databases

EnsemblBacteriaiABK45953; ABK45953; Mmc1_3468.
GeneIDi4482824.
KEGGimgm:Mmc1_3468.
PATRICi22433603. VBIMagSp23654_3527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000471 Genomic DNA. Translation: ABK45953.1 .
RefSeqi YP_867359.1. NC_008576.1.

3D structure databases

ProteinModelPortali A0LDB0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 156889.Mmc1_3468.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK45953 ; ABK45953 ; Mmc1_3468 .
GeneIDi 4482824.
KEGGi mgm:Mmc1_3468.
PATRICi 22433603. VBIMagSp23654_3527.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci MSP156889:GH36-3515-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC-1.

Entry informationi

Entry nameiPUR9_MAGSM
AccessioniPrimary (citable) accession number: A0LDB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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