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A0LDB0

- PUR9_MAGSM

UniProt

A0LDB0 - PUR9_MAGSM

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Magnetococcus sp. (strain MC-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciMSP156889:GH36-3515-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Mmc1_3468
OrganismiMagnetococcus sp. (strain MC-1)
Taxonomic identifieri156889 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus
ProteomesiUP000002586: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Bifunctional purine biosynthesis protein PurHPRO_1000192978Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi156889.Mmc1_3468.

Structurei

3D structure databases

ProteinModelPortaliA0LDB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LDB0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIKRALIS VSDKTGLVPF CQGLAEHGVS FLSTGGTARL LRESGLDVMD
60 70 80 90 100
VSEFTGFPEM LDGRVKTLHP KVHGGLLGLR DNASHQQQMG EHGIEPIDMV
110 120 130 140 150
VVNLYPFEAT VAKEGCTLEE AIENIDIGGP SMLRSAAKNY RSVTVVTDPA
160 170 180 190 200
DYARVLESLR AHDGQCDAGL NAQLARKVYA RTAAYDAAIS NWLSALDNEG
210 220 230 240 250
RPGAFPETYT VQFKKVQGMR YGENPHQSAA FYAESPPSEE ASLATATQLQ
260 270 280 290 300
GKELSFNNIH DANGALELVK EFSKPAAVVV KHANPCGVAV HDGDLLAAYR
310 320 330 340 350
MARDTDPVSA FGGIIALNRC VDVAVAKEIA QLFVEVIIAP EYDEQALELF
360 370 380 390 400
ATKKNLRLLR VPNIGVATAV STMDLKRVTG GLLLQDRDLK QLPEGSLKVV
410 420 430 440 450
TERAPSEAEM RDLLFAWKVV KHVKSNAIVY AKEQRTLGVG AGQMSRVDAS
460 470 480 490 500
RIAVWKAQDT AHTAGLRENP LLGAAMASDA FFPFRDGVDA AAKAGAKAVI
510 520 530
QPGGSVRDEE VIAAANEHGM AMVFTGMRHF KH
Length:532
Mass (Da):57,270
Last modified:December 12, 2006 - v1
Checksum:i9B4C77A1369F150C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000471 Genomic DNA. Translation: ABK45953.1.
RefSeqiYP_867359.1. NC_008576.1.

Genome annotation databases

EnsemblBacteriaiABK45953; ABK45953; Mmc1_3468.
GeneIDi4482824.
KEGGimgm:Mmc1_3468.
PATRICi22433603. VBIMagSp23654_3527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000471 Genomic DNA. Translation: ABK45953.1 .
RefSeqi YP_867359.1. NC_008576.1.

3D structure databases

ProteinModelPortali A0LDB0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 156889.Mmc1_3468.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK45953 ; ABK45953 ; Mmc1_3468 .
GeneIDi 4482824.
KEGGi mgm:Mmc1_3468.
PATRICi 22433603. VBIMagSp23654_3527.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci MSP156889:GH36-3515-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC-1.

Entry informationi

Entry nameiPUR9_MAGSM
AccessioniPrimary (citable) accession number: A0LDB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 12, 2006
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3