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A0L9F4

- UPPP_MAGSM

UniProt

A0L9F4 - UPPP_MAGSM

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Magnetococcus sp. (strain MC-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciMSP156889:GH36-2124-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Mmc1_2096
    OrganismiMagnetococcus sp. (strain MC-1)
    Taxonomic identifieri156889 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus
    ProteomesiUP000002586: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Undecaprenyl-diphosphatasePRO_0000290723Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi156889.Mmc1_2096.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei39 – 5921HelicalUniRule annotationAdd
    BLAST
    Transmembranei87 – 10721HelicalUniRule annotationAdd
    BLAST
    Transmembranei114 – 13421HelicalUniRule annotationAdd
    BLAST
    Transmembranei147 – 16721HelicalUniRule annotationAdd
    BLAST
    Transmembranei193 – 21321HelicalUniRule annotationAdd
    BLAST
    Transmembranei223 – 24321HelicalUniRule annotationAdd
    BLAST
    Transmembranei250 – 27021HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiMEIGTIF.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0L9F4-1 [UniParc]FASTAAdd to Basket

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    MDLFNAAILA LIQGITEFLP ISSSGHLILT PYLLGWQDQG LVFDIAANSG    50
    SLAAVMLYFR REVGQMLRGG WRLLCAPRAW RQANAESHLV LQLALATIPV 100
    GLVGLACKDW VATVARDPMI IATTSILFGL LLWWADRQGR CNNDGSALSW 150
    RQVGIIGIAQ AFALIPGTSR SGVTMTAGLM LGLTREAAAR FSFLMAIPVG 200
    ILAALLDLKD LFAHPMQGDE LYFLGVGFCV SGLSAYMVIH GLLAWLKRQT 250
    MTPFVVYRVV LGVVIFATLG 270
    Length:270
    Mass (Da):29,193
    Last modified:December 12, 2006 - v1
    Checksum:i514BC8C9936F327C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000471 Genomic DNA. Translation: ABK44597.1.
    RefSeqiYP_866003.1. NC_008576.1.

    Genome annotation databases

    EnsemblBacteriaiABK44597; ABK44597; Mmc1_2096.
    GeneIDi4480845.
    KEGGimgm:Mmc1_2096.
    PATRICi22430787. VBIMagSp23654_2139.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000471 Genomic DNA. Translation: ABK44597.1 .
    RefSeqi YP_866003.1. NC_008576.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 156889.Mmc1_2096.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK44597 ; ABK44597 ; Mmc1_2096 .
    GeneIDi 4480845.
    KEGGi mgm:Mmc1_2096.
    PATRICi 22430787. VBIMagSp23654_2139.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi MEIGTIF.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci MSP156889:GH36-2124-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC-1.

    Entry informationi

    Entry nameiUPPP_MAGSM
    AccessioniPrimary (citable) accession number: A0L9F4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3