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A0L8S5

- PDXJ_MAGSM

UniProt

A0L8S5 - PDXJ_MAGSM

Protein

Pyridoxine 5'-phosphate synthase

Gene

pdxJ

Organism
Magnetococcus sp. (strain MC-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.UniRule annotation

    Catalytic activityi

    1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei7 – 713-amino-2-oxopropyl phosphateUniRule annotation
    Binding sitei18 – 1813-amino-2-oxopropyl phosphateUniRule annotation
    Active sitei43 – 431Proton acceptorUniRule annotation
    Binding sitei45 – 4511-deoxy-D-xylulose 5-phosphateUniRule annotation
    Binding sitei50 – 5011-deoxy-D-xylulose 5-phosphateUniRule annotation
    Active sitei70 – 701Proton acceptorUniRule annotation
    Binding sitei100 – 10011-deoxy-D-xylulose 5-phosphateUniRule annotation
    Sitei151 – 1511Transition state stabilizerUniRule annotation
    Active sitei191 – 1911Proton donorUniRule annotation
    Binding sitei192 – 19213-amino-2-oxopropyl phosphate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Enzyme and pathway databases

    BioCyciMSP156889:GH36-1879-MONOMER.
    UniPathwayiUPA00244; UER00313.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyridoxine 5'-phosphate synthaseUniRule annotation (EC:2.6.99.2UniRule annotation)
    Short name:
    PNP synthaseUniRule annotation
    Gene namesi
    Name:pdxJUniRule annotation
    Ordered Locus Names:Mmc1_1860
    OrganismiMagnetococcus sp. (strain MC-1)
    Taxonomic identifieri156889 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus
    ProteomesiUP000002586: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 243243Pyridoxine 5'-phosphate synthasePRO_1000022378Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer; tetramer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi156889.Mmc1_1860.

    Structurei

    3D structure databases

    ProteinModelPortaliA0L8S5.
    SMRiA0L8S5. Positions 2-239.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni9 – 1021-deoxy-D-xylulose 5-phosphate bindingUniRule annotation
    Regioni213 – 21423-amino-2-oxopropyl phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0854.
    HOGENOMiHOG000258095.
    KOiK03474.
    OMAiVPETRQE.
    OrthoDBiEOG6M9F0H.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00279. PdxJ.
    InterProiIPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view]
    PfamiPF03740. PdxJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF63892. SSF63892. 1 hit.
    TIGRFAMsiTIGR00559. pdxJ. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0L8S5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILLGVNIDH IATLRQARGE RYPDPVDAAF AAERAGADSI TVHLREDRRH    50
    IQDRDVVLLQ QTCQTKINLE MAASEPMLTL AERWKPQDCC LVPEKRHELT 100
    TEGGLDVVGN RHRLADAVAR LHDAGIRVSL FVDPDLEQIS AAGAIGATVV 150
    EMHTGRYANA ATQAQRNLEL EQLYRAAHQA SLNGLTVHAG HGLTYHNVQP 200
    IARLPDLKEL NIGHAIIARA VMVGMESAVK EMKRLMREAV KTP 243
    Length:243
    Mass (Da):26,799
    Last modified:December 12, 2006 - v1
    Checksum:i6B275C2FAD05E5D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000471 Genomic DNA. Translation: ABK44368.1.
    RefSeqiYP_865774.1. NC_008576.1.

    Genome annotation databases

    EnsemblBacteriaiABK44368; ABK44368; Mmc1_1860.
    GeneIDi4481758.
    KEGGimgm:Mmc1_1860.
    PATRICi22430309. VBIMagSp23654_1909.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000471 Genomic DNA. Translation: ABK44368.1 .
    RefSeqi YP_865774.1. NC_008576.1.

    3D structure databases

    ProteinModelPortali A0L8S5.
    SMRi A0L8S5. Positions 2-239.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 156889.Mmc1_1860.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK44368 ; ABK44368 ; Mmc1_1860 .
    GeneIDi 4481758.
    KEGGi mgm:Mmc1_1860.
    PATRICi 22430309. VBIMagSp23654_1909.

    Phylogenomic databases

    eggNOGi COG0854.
    HOGENOMi HOG000258095.
    KOi K03474.
    OMAi VPETRQE.
    OrthoDBi EOG6M9F0H.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00313 .
    BioCyci MSP156889:GH36-1879-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00279. PdxJ.
    InterProi IPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view ]
    Pfami PF03740. PdxJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63892. SSF63892. 1 hit.
    TIGRFAMsi TIGR00559. pdxJ. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC-1.

    Entry informationi

    Entry nameiPDXJ_MAGSM
    AccessioniPrimary (citable) accession number: A0L8S5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3