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A0L8S5

- PDXJ_MAGSM

UniProt

A0L8S5 - PDXJ_MAGSM

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Protein

Pyridoxine 5'-phosphate synthase

Gene
pdxJ, Mmc1_1860
Organism
Magnetococcus sp. (strain MC-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate By similarity.UniRule annotation

Catalytic activityi

1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 713-amino-2-oxopropyl phosphate By similarity
Binding sitei18 – 1813-amino-2-oxopropyl phosphate By similarity
Active sitei43 – 431Proton acceptor By similarity
Binding sitei45 – 4511-deoxy-D-xylulose 5-phosphate By similarity
Binding sitei50 – 5011-deoxy-D-xylulose 5-phosphate By similarity
Active sitei70 – 701Proton acceptor By similarity
Binding sitei100 – 10011-deoxy-D-xylulose 5-phosphate By similarity
Sitei151 – 1511Transition state stabilizer By similarity
Active sitei191 – 1911Proton donor By similarity
Binding sitei192 – 19213-amino-2-oxopropyl phosphate; via amide nitrogen By similarity

GO - Molecular functioni

  1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyridoxine biosynthesis

Enzyme and pathway databases

BioCyciMSP156889:GH36-1879-MONOMER.
UniPathwayiUPA00244; UER00313.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxine 5'-phosphate synthase (EC:2.6.99.2)
Short name:
PNP synthase
Gene namesi
Name:pdxJ
Ordered Locus Names:Mmc1_1860
OrganismiMagnetococcus sp. (strain MC-1)
Taxonomic identifieri156889 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus
ProteomesiUP000002586: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Pyridoxine 5'-phosphate synthaseUniRule annotationPRO_1000022378Add
BLAST

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi156889.Mmc1_1860.

Structurei

3D structure databases

ProteinModelPortaliA0L8S5.
SMRiA0L8S5. Positions 2-239.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 1021-deoxy-D-xylulose 5-phosphate binding By similarity
Regioni213 – 21423-amino-2-oxopropyl phosphate binding By similarity

Sequence similaritiesi

Belongs to the PNP synthase family.

Phylogenomic databases

eggNOGiCOG0854.
HOGENOMiHOG000258095.
KOiK03474.
OMAiVPETRQE.
OrthoDBiEOG6M9F0H.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00279. PdxJ.
InterProiIPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view]
PfamiPF03740. PdxJ. 1 hit.
[Graphical view]
SUPFAMiSSF63892. SSF63892. 1 hit.
TIGRFAMsiTIGR00559. pdxJ. 1 hit.

Sequencei

Sequence statusi: Complete.

A0L8S5-1 [UniParc]FASTAAdd to Basket

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MILLGVNIDH IATLRQARGE RYPDPVDAAF AAERAGADSI TVHLREDRRH    50
IQDRDVVLLQ QTCQTKINLE MAASEPMLTL AERWKPQDCC LVPEKRHELT 100
TEGGLDVVGN RHRLADAVAR LHDAGIRVSL FVDPDLEQIS AAGAIGATVV 150
EMHTGRYANA ATQAQRNLEL EQLYRAAHQA SLNGLTVHAG HGLTYHNVQP 200
IARLPDLKEL NIGHAIIARA VMVGMESAVK EMKRLMREAV KTP 243
Length:243
Mass (Da):26,799
Last modified:December 12, 2006 - v1
Checksum:i6B275C2FAD05E5D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000471 Genomic DNA. Translation: ABK44368.1.
RefSeqiYP_865774.1. NC_008576.1.

Genome annotation databases

EnsemblBacteriaiABK44368; ABK44368; Mmc1_1860.
GeneIDi4481758.
KEGGimgm:Mmc1_1860.
PATRICi22430309. VBIMagSp23654_1909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000471 Genomic DNA. Translation: ABK44368.1 .
RefSeqi YP_865774.1. NC_008576.1.

3D structure databases

ProteinModelPortali A0L8S5.
SMRi A0L8S5. Positions 2-239.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 156889.Mmc1_1860.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK44368 ; ABK44368 ; Mmc1_1860 .
GeneIDi 4481758.
KEGGi mgm:Mmc1_1860.
PATRICi 22430309. VBIMagSp23654_1909.

Phylogenomic databases

eggNOGi COG0854.
HOGENOMi HOG000258095.
KOi K03474.
OMAi VPETRQE.
OrthoDBi EOG6M9F0H.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00313 .
BioCyci MSP156889:GH36-1879-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00279. PdxJ.
InterProi IPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view ]
Pfami PF03740. PdxJ. 1 hit.
[Graphical view ]
SUPFAMi SSF63892. SSF63892. 1 hit.
TIGRFAMsi TIGR00559. pdxJ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC-1.

Entry informationi

Entry nameiPDXJ_MAGSM
AccessioniPrimary (citable) accession number: A0L8S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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