ID   A0L8S3_MAGMM            Unreviewed;       734 AA.
AC   A0L8S3;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:ABK44366.1};
GN   OrderedLocusNames=Mmc1_1858 {ECO:0000313|EMBL:ABK44366.1};
OS   Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Magnetococcales;
OC   Magnetococcaceae; Magnetococcus.
OX   NCBI_TaxID=156889 {ECO:0000313|EMBL:ABK44366.1, ECO:0000313|Proteomes:UP000002586};
RN   [1] {ECO:0000313|Proteomes:UP000002586}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1437 / JCM 17883 / MC-1
RC   {ECO:0000313|Proteomes:UP000002586};
RX   PubMed=19465526; DOI=10.1128/AEM.02874-08;
RA   Schubbe S., Williams T.J., Xie G., Kiss H.E., Brettin T.S., Martinez D.,
RA   Ross C.A., Schuler D., Cox B.L., Nealson K.H., Bazylinski D.A.;
RT   "Complete genome sequence of the chemolithoautotrophic marine magnetotactic
RT   coccus strain MC-1.";
RL   Appl. Environ. Microbiol. 75:4835-4852(2009).
RN   [2] {ECO:0000313|EMBL:ABK44366.1, ECO:0000313|Proteomes:UP000002586}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1437 / JCM 17883 / MC-1
RC   {ECO:0000313|Proteomes:UP000002586};
RX   PubMed=22581902;
RA   Bazylinski D.A., Williams T.J., Lefevre C.T., Berg R.J., Zhang C.L.,
RA   Bowser S.S., Dean A.J., Beveridge T.J.;
RT   "Magnetococcus marinus gen. nov., sp. nov., a marine, magnetotactic
RT   bacterium that represents a novel lineage (Magnetococcaceae fam. nov.;
RT   Magnetococcales ord. nov.) at the base of the Alphaproteobacteria.";
RL   Int. J. Syst. Evol. Microbiol. 0:0-0(2012).
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DR   EMBL; CP000471; ABK44366.1; -; Genomic_DNA.
DR   RefSeq; WP_011713510.1; NC_008576.1.
DR   AlphaFoldDB; A0L8S3; -.
DR   STRING; 156889.Mmc1_1858; -.
DR   KEGG; mgm:Mmc1_1858; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG4252; Bacteria.
DR   HOGENOM; CLU_000445_85_1_5; -.
DR   OrthoDB; 9789782at2; -.
DR   Proteomes; UP000002586; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR007890; CHASE2.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF05226; CHASE2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM01080; CHASE2; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002586};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        363..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        415..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          479..611
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   734 AA;  81552 MW;  A411242B9FC8C738 CRC64;
     MEKIKKTIWF RYAGSFLLVL IFLLLSLNII PSTLFVQLDH QIYDTQLRTT MPGRLESQIV
     ILDVDERSLA RVGRWPWPRN QLAQLVNTLF DQYQINSLGF DFVFAEEDKA GGLEVLEHLA
     TGPLKDFPLF QTTFAKLRPT LLHDTIFARA LTDRPVVMGY YFKQRNDKGG QSGQLPPPLA
     TLDKLEAQQF PGMQPESFGA NLQILQNQAR EGGFFDNPLV DQDGVFRRVP LLQVHNGGIY
     GSLALNLLRT ALGTPTLSIS PTGDAIWLDD GAFRIPVDRD MAVLVPYMGP QGSFPYISAA
     DVLEGRVAQD KLEGRIVLMG TTAPGLLDLR STPVQHVYPG VEIHANIIAG IMDGRIKSRP
     AEMFLIELSA LLVLGILLTL LLPRLSPMLG TLLTASSLAA VVVATLLTWQ KGMVMHVGLL
     LSLTILLYIY HMAYGFFVES RSKRQISKTF GQYIPSELVD EMTASGSDVS IGGESRTMTV
     LFSDVRSFTT ISEGLKPDEL TSLMNSFLTP MTRVIHENRG TIDKYMGDAI MAFWGAPLHD
     PEHTRHAVRS AFQMIEAMQA LSVAFKAKGW PELKIGVGIN TGTMNVGNMG SEFRMAYTVL
     GDAVNLGSRL EGLTKQYGVD IILGQGSKAE VVDLVCRELD LVRVKGKAEP IAIYEPVGFT
     SEVDEARLSE LEQYHQALSL YRQQQWQEAE ALLTALQTAE PSRMIYQIYL DRIAHFKVEP
     PDELWDGVFT HTSK
//