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A0L8H9

- NADK_MAGSM

UniProt

A0L8H9 - NADK_MAGSM

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Protein
NAD kinase
Gene
nadK, Mmc1_1764
Organism
Magnetococcus sp. (strain MC-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei71 – 711Proton acceptor By similarity
Binding sitei156 – 1561NAD By similarity
Binding sitei173 – 1731NAD By similarity
Binding sitei175 – 1751NAD By similarity
Binding sitei245 – 2451NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 722NAD By similarity
Nucleotide bindingi145 – 1462NAD By similarity
Nucleotide bindingi186 – 1916NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP156889:GH36-1783-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:Mmc1_1764
OrganismiMagnetococcus sp. (strain MC-1)
Taxonomic identifieri156889 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus
ProteomesiUP000002586: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303NAD kinaseUniRule annotation
PRO_1000079500Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi156889.Mmc1_1764.

Structurei

3D structure databases

ProteinModelPortaliA0L8H9.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiGAEFCLN.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A0L8H9-1 [UniParc]FASTAAdd to Basket

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MNSIGLVTKL SDPMAIRATS ELTEWLNKQH RRVTVTAEAA KAANISPKLA    50
AIKPLEDIGE GQDLVIVLGG DGTFIGAARD VLRWKVPVLG VNMGRLGFLT 100
EVSYDEMYDN LKEVFAGHYN VEDRMMLTAF IRRESGEVLS HHVLNDVVAH 150
KGHLARMMEF QVSINGQHVF TSRADGLIVA TPTGSTGYSL SAGGPIIHPR 200
LDTIIINPIC PHTLSNRPIA VPGDGQISFR LTQNEPDRLL TLDGQTGVPL 250
LDGDEIVIRK SDRSLRVIHS PDRNYYDILR KKLHWAETVG TKRDLSLRPA 300
DDR 303
Length:303
Mass (Da):33,466
Last modified:December 12, 2006 - v1
Checksum:i22BD4AF5F261B35E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000471 Genomic DNA. Translation: ABK44272.1.
RefSeqiYP_865678.1. NC_008576.1.

Genome annotation databases

EnsemblBacteriaiABK44272; ABK44272; Mmc1_1764.
GeneIDi4482590.
KEGGimgm:Mmc1_1764.
PATRICi22430111. VBIMagSp23654_1810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000471 Genomic DNA. Translation: ABK44272.1 .
RefSeqi YP_865678.1. NC_008576.1.

3D structure databases

ProteinModelPortali A0L8H9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 156889.Mmc1_1764.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK44272 ; ABK44272 ; Mmc1_1764 .
GeneIDi 4482590.
KEGGi mgm:Mmc1_1764.
PATRICi 22430111. VBIMagSp23654_1810.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi GAEFCLN.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci MSP156889:GH36-1783-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC-1.

Entry informationi

Entry nameiNADK_MAGSM
AccessioniPrimary (citable) accession number: A0L8H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 12, 2006
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3