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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciMMAR156889:G1G7E-1639-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Mmc1_1560
OrganismiMagnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)
Taxonomic identifieri156889 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus
Proteomesi
  • UP000002586 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456661 – 461Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST461

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi156889.Mmc1_1560

Structurei

3D structure databases

ProteinModelPortaliA0L7X6
SMRiA0L7X6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

A0L7X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFIPHTEDD VRLMLDTIGV ESIDALFDEI PAELNTHPIL ESVPKPQSEA
60 70 80 90 100
ATLRLQSARA REGDGRLNFI GAGAYEHHIP AAVWELVTRG EFYSAYTPYQ
110 120 130 140 150
AEASQGILQT IYEFQSMMAG LMGMDLSNAS LYDGATALAE AVLMAVRANP
160 170 180 190 200
APRGSTPRVI MPATVHPAYR EVVQTMVRHQ GIELVEPSFC AKRGGVAVSA
210 220 230 240 250
LNLYADEPVQ ALVIAQPNFF GQLEDVDFLT NWAHKRGALV IGVVNPVAMA
260 270 280 290 300
LLKPPAAWGE KGADIACGEG QPLGVPLSFG GPYLGFLSCR QALARQMPGR
310 320 330 340 350
IVGRTLDQEG KEGFVLTLQA REQHIRRAKA TSNICTNQGL LSIAATIHMA
360 370 380 390 400
MLGPEGLKNV ALTCHRRTQQ LWQRLALLEG VERCFEGPFF HEVAIKLSKP
410 420 430 440 450
AEEVLTCLSG VNIAGGYAVG RRYPGMENVL LVCCTETKER SDLDHYADAL
460
GLIMSEQGSA A
Length:461
Mass (Da):49,931
Last modified:December 12, 2006 - v1
Checksum:i0F80DA3E08AEBF74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000471 Genomic DNA Translation: ABK44069.1
RefSeqiWP_011713219.1, NC_008576.1

Genome annotation databases

EnsemblBacteriaiABK44069; ABK44069; Mmc1_1560
KEGGimgm:Mmc1_1560

Similar proteinsi

Entry informationi

Entry nameiGCSPA_MAGMM
AccessioniPrimary (citable) accession number: A0L7X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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