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A0L7X6 (GCSPA_MAGSM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Mmc1_1560
OrganismMagnetococcus sp. (strain MC-1) [Complete proteome] [HAMAP]
Taxonomic identifier156889 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045666

Sequences

Sequence LengthMass (Da)Tools
A0L7X6 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 0F80DA3E08AEBF74

FASTA46149,931
        10         20         30         40         50         60 
MPFIPHTEDD VRLMLDTIGV ESIDALFDEI PAELNTHPIL ESVPKPQSEA ATLRLQSARA 

        70         80         90        100        110        120 
REGDGRLNFI GAGAYEHHIP AAVWELVTRG EFYSAYTPYQ AEASQGILQT IYEFQSMMAG 

       130        140        150        160        170        180 
LMGMDLSNAS LYDGATALAE AVLMAVRANP APRGSTPRVI MPATVHPAYR EVVQTMVRHQ 

       190        200        210        220        230        240 
GIELVEPSFC AKRGGVAVSA LNLYADEPVQ ALVIAQPNFF GQLEDVDFLT NWAHKRGALV 

       250        260        270        280        290        300 
IGVVNPVAMA LLKPPAAWGE KGADIACGEG QPLGVPLSFG GPYLGFLSCR QALARQMPGR 

       310        320        330        340        350        360 
IVGRTLDQEG KEGFVLTLQA REQHIRRAKA TSNICTNQGL LSIAATIHMA MLGPEGLKNV 

       370        380        390        400        410        420 
ALTCHRRTQQ LWQRLALLEG VERCFEGPFF HEVAIKLSKP AEEVLTCLSG VNIAGGYAVG 

       430        440        450        460 
RRYPGMENVL LVCCTETKER SDLDHYADAL GLIMSEQGSA A 

« Hide

References

[1]"Complete sequence of Magnetococcus sp. MC-1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Goodwin L.A., Brettin T., Bruce D., Han C., Tapia R., Gilna P. expand/collapse author list , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MC-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000471 Genomic DNA. Translation: ABK44069.1.
RefSeqYP_865475.1. NC_008576.1.

3D structure databases

ProteinModelPortalA0L7X6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING156889.Mmc1_1560.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK44069; ABK44069; Mmc1_1560.
GeneID4484178.
KEGGmgm:Mmc1_1560.
PATRIC22429689. VBIMagSp23654_1600.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycMSP156889:GH36-1577-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_MAGSM
AccessionPrimary (citable) accession number: A0L7X6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families