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Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Gene

murA

Organism
Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93UDP-N-acetylglucosamineUniRule annotation1
Active sitei117Proton donorUniRule annotation1
Binding sitei306UDP-N-acetylglucosamineUniRule annotation1
Binding sitei328UDP-N-acetylglucosamine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandPyruvate

Enzyme and pathway databases

BioCyciMMAR156889:G1G7E-1290-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferaseUniRule annotation (EC:2.5.1.7UniRule annotation)
Alternative name(s):
Enoylpyruvate transferaseUniRule annotation
UDP-N-acetylglucosamine enolpyruvyl transferaseUniRule annotation
Short name:
EPTUniRule annotation
Gene namesi
Name:murAUniRule annotation
Ordered Locus Names:Mmc1_1221
OrganismiMagnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)
Taxonomic identifieri156889 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus
Proteomesi
  • UP000002586 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000230521 – 419UDP-N-acetylglucosamine 1-carboxyvinyltransferaseAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1172-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation1

Proteomic databases

PRIDEiA0L6Y9

Interactioni

Protein-protein interaction databases

STRINGi156889.Mmc1_1221

Structurei

3D structure databases

ProteinModelPortaliA0L6Y9
SMRiA0L6Y9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 23Phosphoenolpyruvate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDF Bacteria
COG0766 LUCA
HOGENOMiHOG000075602
KOiK00790
OMAiCDPHRAT
OrthoDBiPOG091H01PG

Family and domain databases

CDDicd01555 UdpNAET, 1 hit
Gene3Di3.65.10.10, 3 hits
HAMAPiMF_00111 MurA, 1 hit
InterProiView protein in InterPro
IPR001986 Enolpyruvate_Tfrase_dom
IPR036968 Enolpyruvate_Tfrase_sf
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
IPR005750 UDP_GlcNAc_COvinyl_MurA
PfamiView protein in Pfam
PF00275 EPSP_synthase, 1 hit
SUPFAMiSSF55205 SSF55205, 1 hit
TIGRFAMsiTIGR01072 murA, 1 hit

Sequencei

Sequence statusi: Complete.

A0L6Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKILVRGGN TLKGTIPISG AKNACLPELA ATLLTEDTVT LRNVPHLRDV
60 70 80 90 100
TTMLELLGQH GAAITIDEKL GVSIDCKSIQ NTMAPYDLVR TMRASVLVMG
110 120 130 140 150
PLVARCGHAE ISLPGGCAIG SRPINLHLRG LEMMGAHVTL EDGYVRIKAG
160 170 180 190 200
RLKGAHIVFD LVTVTGTENL LMAATLADGI TILDNAAAEP EVVDLANLLM
210 220 230 240 250
AMGAKIDGAG TRTITIEGVK NLHGTSHDIL PDRIETGTFM VAAAVTGGDI
260 270 280 290 300
TMTGTYPALL EAHIAKMREA GCQIDEMDRA IRVRAEAGTL RAVDITTLPH
310 320 330 340 350
PGFPTDLQAQ MMVLLTVAKG AAQIKETIFE NRFMHVSELQ RMGADITVQG
360 370 380 390 400
NTAIVRGVPQ LRGAPVMATD LRASASLVLA GLCAEGETLI SRVYHIDRGY
410
ERIEEKLKAL GADIQRLGR
Length:419
Mass (Da):44,625
Last modified:December 12, 2006 - v1
Checksum:iD35BA85106532E1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000471 Genomic DNA Translation: ABK43732.1
RefSeqiWP_011712887.1, NC_008576.1

Genome annotation databases

EnsemblBacteriaiABK43732; ABK43732; Mmc1_1221
KEGGimgm:Mmc1_1221

Similar proteinsi

Entry informationi

Entry nameiMURA_MAGMM
AccessioniPrimary (citable) accession number: A0L6Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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