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A0L576 (ACSA_MAGSM) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene names
Name:acsA
Ordered Locus Names:Mmc1_0598
OrganismMagnetococcus sp. (strain MC-1) [Complete proteome] [HAMAP]
Taxonomic identifier156889 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Magnetococcus

Protein attributes

Sequence length644 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   PTMAcetylation
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionAMP binding

Inferred from electronic annotation. Source: InterPro

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate-CoA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 644644Acetyl-coenzyme A synthetase HAMAP MF_01123
PRO_1000065295

Sites

Active site5141 By similarity

Amino acid modifications

Modified residue6061N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A0L576 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 6FBDDFBA7473755A

FASTA64471,653
        10         20         30         40         50         60 
MSDVKVYPVD PNVAANALIN EEQYQEMYKR SIDDPAAFWA EQAEARIDWF KKWDNVLDFD 

        70         80         90        100        110        120 
LRKGHIKWFE GAKLNVSYNC IDRHLEKRGD KVAILWEGDN PAADRKITYR ELSALVNKFA 

       130        140        150        160        170        180 
NALKARGVKK GDRVCIYMPM IPEAAVAMLA CTRIGAVHSI VFGGFSPDAL RDRIIDAECR 

       190        200        210        220        230        240 
VVITADGGMR GSKKIPLRKN VETALAQCPN VHTCFVVQDT QLEIEWTEGR DVWYHEAIAA 

       250        260        270        280        290        300 
ASADCPPEEM DAEDPLFVLY TSGSTGKPKG VLHTTGGYLL YASITHQYIF DYHEDDIYWC 

       310        320        330        340        350        360 
TADVGWVTGH TYIVYGPLAN GATTLMFEGV PTYPDASRFW QVVDKHQVSI FYTAPTAIRS 

       370        380        390        400        410        420 
IMSQGDALVK ATSRQSLRIL GSVGEPINPE AWEWYYHVVG EGRCPIVDTW WQTETGGILI 

       430        440        450        460        470        480 
TPLPGATPLK PGSATRPFFG VNPKVLSNEG KEMEGPCEGI LVLDHPWPGM MRTVYGDHDR 

       490        500        510        520        530        540 
FINTYFANYP GYYFCGDGCR RDEDGYYWIT GRVDDVINVS GHRLGTAEVE SALVLHDQVA 

       550        560        570        580        590        600 
EAAVVGMPHE IKGQGIYAYV TLMSGVEPSD ALKTELVKLV RKEIGPIASL DVIQFAPGLP 

       610        620        630        640 
KTRSGKIMRR ILRKIAAHEV DTLGDTSTLA DPSVVQNLID NMPK

« Hide

References

[1]"Complete sequence of Magnetococcus sp. MC-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Goodwin L.A., Brettin T., Bruce D., Han C., Tapia R., Gilna P. expand/collapse author list , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MC-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000471 Genomic DNA. Translation: ABK43119.1.
RefSeqYP_864525.1. NC_008576.1.

3D structure databases

ProteinModelPortalA0L576.
SMRA0L576. Positions 7-640.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0L576.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4481798.
GenomeReviewsGene locus Mmc1_0598 in contig CP000471_GR.
KEGGmgm:Mmc1_0598.
NMPDRfig|156889.1.peg.3477.
PATRIC22427708. VBIMagSp23654_0621.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0365.
HOGENOMHBG547964.
OMAHQRMVDT.
PhylomeDBA0L576.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACSA_MAGSM
AccessionPrimary (citable) accession number: A0L576
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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