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A0L4R4

- SYL_MAGSM

UniProt

A0L4R4 - SYL_MAGSM

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Magnetococcus sp. (strain MC-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei617 – 6171ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP156889:GH36-437-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mmc1_0432
OrganismiMagnetococcus sp. (strain MC-1)
Taxonomic identifieri156889 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus
ProteomesiUP000002586: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Leucine--tRNA ligasePRO_1000071112Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi156889.Mmc1_0432.

Structurei

3D structure databases

ProteinModelPortaliA0L4R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi614 – 6185"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0L4R4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQKYNPQAI ESKWQKIWHQ QKTFATPENL GDKETFYLLV MFPYPSGRIH
60 70 80 90 100
MGHVRNYAIG DVIARYQRMQ GKAVLHPMGW DAFGMPAENA AAQRKVHPRD
110 120 130 140 150
WTYENIATMR EELKSMGLSY DWDREFATCD EDYAHAEQVL FLRLYEKGLV
160 170 180 190 200
YRKHAFVNWD PVDHTVLANE QVIDGCGWRS GAPVEQRELN QWFFRITHYA
210 220 230 240 250
DELLDNLQHM DGWPETVRTM QTNWIGKSHG VEFAFALEGY PGTLPVYTTR
260 270 280 290 300
PDTLMGVTFC SVAAEHPIAA AVAENNPAAA AFIKTCQGVG TSEEALEKLE
310 320 330 340 350
KKGFDTGIKA IHPITGESLP VYIANFVLMS YGTGAVMAVP AHDQRDFEFA
360 370 380 390 400
KKHGIEIKVV IQPEGQTLHA EQLSEAYTGP GRLVNSGLFT GMDNEQAKQR
410 420 430 440 450
VAEYFEAQGI GKGTINYRLR DWGISRQRYW GNPIPMVHCA ACGVVPVPVA
460 470 480 490 500
QLPIQLPNEV DFSEPGNPLE RHPSWKTCDC PQCGQPARRE TDTMDTFMES
510 520 530 540 550
SWYFLRYCSP HMGGVPLDKA AVDRWMPVNQ YVGGIEHAVL HLLYARFFHK
560 570 580 590 600
ALRDIGEVSC DEPFARLLTQ GMVRKDTHRC AQHGWRYPKE VQERDGALYC
610 620 630 640 650
IECGGAVTVG RNEKMSKSKH NVVDPNDLIA GYGADTARLF MLFAAPADRD
660 670 680 690 700
LEWNDSGVDG AWRFLGRVWR LVLAAIERCG ERQACTTTPA DEQLKAFRSQ
710 720 730 740 750
LHNTIVKVTE DLNRQSFNTA IAAVMEMSNG AIATFKGEDR LTGEASALLW
760 770 780 790 800
ETAQVTVKLL HPYAPHMTEE LWQRMGEQSL LSDTPWPLAD AAALVKERVL
810 820 830 840 850
IVIQVNGKLR SKLEVPVDMA QEAIEKLALA DEHVKVQTEG KTIRKVVVVP

GRLVNIVAN
Length:859
Mass (Da):96,647
Last modified:December 12, 2006 - v1
Checksum:i26A931CD311A35D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000471 Genomic DNA. Translation: ABK42957.1.
RefSeqiYP_864363.1. NC_008576.1.

Genome annotation databases

EnsemblBacteriaiABK42957; ABK42957; Mmc1_0432.
GeneIDi4483919.
KEGGimgm:Mmc1_0432.
PATRICi22427378. VBIMagSp23654_0456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000471 Genomic DNA. Translation: ABK42957.1 .
RefSeqi YP_864363.1. NC_008576.1.

3D structure databases

ProteinModelPortali A0L4R4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 156889.Mmc1_0432.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK42957 ; ABK42957 ; Mmc1_0432 .
GeneIDi 4483919.
KEGGi mgm:Mmc1_0432.
PATRICi 22427378. VBIMagSp23654_0456.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MSP156889:GH36-437-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC-1.

Entry informationi

Entry nameiSYL_MAGSM
AccessioniPrimary (citable) accession number: A0L4R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3