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A0L4R4

- SYL_MAGSM

UniProt

A0L4R4 - SYL_MAGSM

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Magnetococcus sp. (strain MC-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei617 – 6171ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMSP156889:GH36-437-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Mmc1_0432
    OrganismiMagnetococcus sp. (strain MC-1)
    Taxonomic identifieri156889 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus
    ProteomesiUP000002586: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 859859Leucine--tRNA ligasePRO_1000071112Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi156889.Mmc1_0432.

    Structurei

    3D structure databases

    ProteinModelPortaliA0L4R4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi614 – 6185"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0L4R4-1 [UniParc]FASTAAdd to Basket

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    MDQKYNPQAI ESKWQKIWHQ QKTFATPENL GDKETFYLLV MFPYPSGRIH    50
    MGHVRNYAIG DVIARYQRMQ GKAVLHPMGW DAFGMPAENA AAQRKVHPRD 100
    WTYENIATMR EELKSMGLSY DWDREFATCD EDYAHAEQVL FLRLYEKGLV 150
    YRKHAFVNWD PVDHTVLANE QVIDGCGWRS GAPVEQRELN QWFFRITHYA 200
    DELLDNLQHM DGWPETVRTM QTNWIGKSHG VEFAFALEGY PGTLPVYTTR 250
    PDTLMGVTFC SVAAEHPIAA AVAENNPAAA AFIKTCQGVG TSEEALEKLE 300
    KKGFDTGIKA IHPITGESLP VYIANFVLMS YGTGAVMAVP AHDQRDFEFA 350
    KKHGIEIKVV IQPEGQTLHA EQLSEAYTGP GRLVNSGLFT GMDNEQAKQR 400
    VAEYFEAQGI GKGTINYRLR DWGISRQRYW GNPIPMVHCA ACGVVPVPVA 450
    QLPIQLPNEV DFSEPGNPLE RHPSWKTCDC PQCGQPARRE TDTMDTFMES 500
    SWYFLRYCSP HMGGVPLDKA AVDRWMPVNQ YVGGIEHAVL HLLYARFFHK 550
    ALRDIGEVSC DEPFARLLTQ GMVRKDTHRC AQHGWRYPKE VQERDGALYC 600
    IECGGAVTVG RNEKMSKSKH NVVDPNDLIA GYGADTARLF MLFAAPADRD 650
    LEWNDSGVDG AWRFLGRVWR LVLAAIERCG ERQACTTTPA DEQLKAFRSQ 700
    LHNTIVKVTE DLNRQSFNTA IAAVMEMSNG AIATFKGEDR LTGEASALLW 750
    ETAQVTVKLL HPYAPHMTEE LWQRMGEQSL LSDTPWPLAD AAALVKERVL 800
    IVIQVNGKLR SKLEVPVDMA QEAIEKLALA DEHVKVQTEG KTIRKVVVVP 850
    GRLVNIVAN 859
    Length:859
    Mass (Da):96,647
    Last modified:December 12, 2006 - v1
    Checksum:i26A931CD311A35D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000471 Genomic DNA. Translation: ABK42957.1.
    RefSeqiYP_864363.1. NC_008576.1.

    Genome annotation databases

    EnsemblBacteriaiABK42957; ABK42957; Mmc1_0432.
    GeneIDi4483919.
    KEGGimgm:Mmc1_0432.
    PATRICi22427378. VBIMagSp23654_0456.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000471 Genomic DNA. Translation: ABK42957.1 .
    RefSeqi YP_864363.1. NC_008576.1.

    3D structure databases

    ProteinModelPortali A0L4R4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 156889.Mmc1_0432.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK42957 ; ABK42957 ; Mmc1_0432 .
    GeneIDi 4483919.
    KEGGi mgm:Mmc1_0432.
    PATRICi 22427378. VBIMagSp23654_0456.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MSP156889:GH36-437-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC-1.

    Entry informationi

    Entry nameiSYL_MAGSM
    AccessioniPrimary (citable) accession number: A0L4R4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3