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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei617ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR156889:G1G7E-451-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mmc1_0432
OrganismiMagnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)
Taxonomic identifieri156889 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus
Proteomesi
  • UP000002586 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000711121 – 859Leucine--tRNA ligaseAdd BLAST859

Proteomic databases

PRIDEiA0L4R4

Interactioni

Protein-protein interaction databases

STRINGi156889.Mmc1_0432

Structurei

3D structure databases

ProteinModelPortaliA0L4R4
SMRiA0L4R4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi614 – 618"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0L4R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQKYNPQAI ESKWQKIWHQ QKTFATPENL GDKETFYLLV MFPYPSGRIH
60 70 80 90 100
MGHVRNYAIG DVIARYQRMQ GKAVLHPMGW DAFGMPAENA AAQRKVHPRD
110 120 130 140 150
WTYENIATMR EELKSMGLSY DWDREFATCD EDYAHAEQVL FLRLYEKGLV
160 170 180 190 200
YRKHAFVNWD PVDHTVLANE QVIDGCGWRS GAPVEQRELN QWFFRITHYA
210 220 230 240 250
DELLDNLQHM DGWPETVRTM QTNWIGKSHG VEFAFALEGY PGTLPVYTTR
260 270 280 290 300
PDTLMGVTFC SVAAEHPIAA AVAENNPAAA AFIKTCQGVG TSEEALEKLE
310 320 330 340 350
KKGFDTGIKA IHPITGESLP VYIANFVLMS YGTGAVMAVP AHDQRDFEFA
360 370 380 390 400
KKHGIEIKVV IQPEGQTLHA EQLSEAYTGP GRLVNSGLFT GMDNEQAKQR
410 420 430 440 450
VAEYFEAQGI GKGTINYRLR DWGISRQRYW GNPIPMVHCA ACGVVPVPVA
460 470 480 490 500
QLPIQLPNEV DFSEPGNPLE RHPSWKTCDC PQCGQPARRE TDTMDTFMES
510 520 530 540 550
SWYFLRYCSP HMGGVPLDKA AVDRWMPVNQ YVGGIEHAVL HLLYARFFHK
560 570 580 590 600
ALRDIGEVSC DEPFARLLTQ GMVRKDTHRC AQHGWRYPKE VQERDGALYC
610 620 630 640 650
IECGGAVTVG RNEKMSKSKH NVVDPNDLIA GYGADTARLF MLFAAPADRD
660 670 680 690 700
LEWNDSGVDG AWRFLGRVWR LVLAAIERCG ERQACTTTPA DEQLKAFRSQ
710 720 730 740 750
LHNTIVKVTE DLNRQSFNTA IAAVMEMSNG AIATFKGEDR LTGEASALLW
760 770 780 790 800
ETAQVTVKLL HPYAPHMTEE LWQRMGEQSL LSDTPWPLAD AAALVKERVL
810 820 830 840 850
IVIQVNGKLR SKLEVPVDMA QEAIEKLALA DEHVKVQTEG KTIRKVVVVP

GRLVNIVAN
Length:859
Mass (Da):96,647
Last modified:December 12, 2006 - v1
Checksum:i26A931CD311A35D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000471 Genomic DNA Translation: ABK42957.1
RefSeqiWP_011712127.1, NC_008576.1

Genome annotation databases

EnsemblBacteriaiABK42957; ABK42957; Mmc1_0432
KEGGimgm:Mmc1_0432

Similar proteinsi

Entry informationi

Entry nameiSYL_MAGMM
AccessioniPrimary (citable) accession number: A0L4R4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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