Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei84S-adenosyl-L-methionineUniRule annotation1
Binding sitei109S-adenosyl-L-methionineUniRule annotation1
Binding sitei136S-adenosyl-L-methionineUniRule annotation1
Active sitei159By similarity1
Binding sitei159S-adenosyl-L-methionineUniRule annotation1
Binding sitei163SubstrateUniRule annotation1
Binding sitei195SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMMAR156889:G1G7E-423-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Mmc1_0405
OrganismiMagnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)
Taxonomic identifieri156889 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus
Proteomesi
  • UP000002586 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002881731 – 253tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST253

Interactioni

Protein-protein interaction databases

STRINGi156889.Mmc1_0405

Structurei

3D structure databases

ProteinModelPortaliA0L4N8
SMRiA0L4N8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni232 – 235Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ1 Bacteria
COG0220 LUCA
HOGENOMiHOG000073968
KOiK03439
OMAiGHALEYC
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

A0L4N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTPMPQPD QAPPVDVGQP VDEAEAKRRR FKTHGRKKGK VNDTRLARIE
60 70 80 90 100
AGLLALSLPP GSADRGALID QLGGNGQSQR VILEIGFGNG ETLAALAARH
110 120 130 140 150
PEDCFIGIDV FLEGFGTLLN RLTRGDISNV RLVCQNALQV LLERIPDASL
160 170 180 190 200
DGVIINFPDP WRKKRHFKRR IVQTEFLDAL APKMRSGADL TLATDWANYA
210 220 230 240 250
EWMVAHLEPH TAFVNQAEPG PFAAPPPWWI ETNFERKGVA AGRIIRHLHY

KKR
Length:253
Mass (Da):28,129
Last modified:December 12, 2006 - v1
Checksum:iEEA696FB6ACF6640
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000471 Genomic DNA Translation: ABK42931.1
RefSeqiWP_011712101.1, NC_008576.1

Genome annotation databases

EnsemblBacteriaiABK42931; ABK42931; Mmc1_0405
KEGGimgm:Mmc1_0405

Similar proteinsi

Entry informationi

Entry nameiTRMB_MAGMM
AccessioniPrimary (citable) accession number: A0L4N8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health