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A0L4N8

- TRMB_MAGSM

UniProt

A0L4N8 - TRMB_MAGSM

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Magnetococcus sp. (strain MC-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei84 – 841S-adenosyl-L-methionineUniRule annotation
    Binding sitei109 – 1091S-adenosyl-L-methionineUniRule annotation
    Binding sitei136 – 1361S-adenosyl-L-methionineUniRule annotation
    Active sitei159 – 1591By similarity
    Binding sitei159 – 1591S-adenosyl-L-methionineUniRule annotation
    Binding sitei163 – 1631SubstrateUniRule annotation
    Binding sitei195 – 1951SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMSP156889:GH36-410-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Mmc1_0405
    OrganismiMagnetococcus sp. (strain MC-1)
    Taxonomic identifieri156889 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaMagnetococcalesMagnetococcaceaeMagnetococcus
    ProteomesiUP000002586: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 253253tRNA (guanine-N(7)-)-methyltransferasePRO_0000288173Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi156889.Mmc1_0405.

    Structurei

    3D structure databases

    ProteinModelPortaliA0L4N8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni232 – 2354Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiTSATNDY.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0L4N8-1 [UniParc]FASTAAdd to Basket

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    MSQTPMPQPD QAPPVDVGQP VDEAEAKRRR FKTHGRKKGK VNDTRLARIE    50
    AGLLALSLPP GSADRGALID QLGGNGQSQR VILEIGFGNG ETLAALAARH 100
    PEDCFIGIDV FLEGFGTLLN RLTRGDISNV RLVCQNALQV LLERIPDASL 150
    DGVIINFPDP WRKKRHFKRR IVQTEFLDAL APKMRSGADL TLATDWANYA 200
    EWMVAHLEPH TAFVNQAEPG PFAAPPPWWI ETNFERKGVA AGRIIRHLHY 250
    KKR 253
    Length:253
    Mass (Da):28,129
    Last modified:December 12, 2006 - v1
    Checksum:iEEA696FB6ACF6640
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000471 Genomic DNA. Translation: ABK42931.1.
    RefSeqiYP_864337.1. NC_008576.1.

    Genome annotation databases

    EnsemblBacteriaiABK42931; ABK42931; Mmc1_0405.
    GeneIDi4480889.
    KEGGimgm:Mmc1_0405.
    PATRICi22427324. VBIMagSp23654_0429.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000471 Genomic DNA. Translation: ABK42931.1 .
    RefSeqi YP_864337.1. NC_008576.1.

    3D structure databases

    ProteinModelPortali A0L4N8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 156889.Mmc1_0405.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK42931 ; ABK42931 ; Mmc1_0405 .
    GeneIDi 4480889.
    KEGGi mgm:Mmc1_0405.
    PATRICi 22427324. VBIMagSp23654_0429.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi TSATNDY.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci MSP156889:GH36-410-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC-1.

    Entry informationi

    Entry nameiTRMB_MAGSM
    AccessioniPrimary (citable) accession number: A0L4N8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3