A0L3K8 (AROE_MAGSM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Mmc1_0022

Organism

Magnetococcus sp. (strain MC-1) [Complete proteome] [HAMAP]

Taxonomic identifier

156889 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Magnetococcus

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325133
Regions
	Nucleotide binding	138 – 142	5	NADP By similarity
Sites
	Active site	76	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A0L3K8 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: D49FFCFA7F9EA55B	FASTA	286	30,863
	10 20 30 40 50 60 MLSKALNING ETGLLAVIGD PVSHSLSPKM HNLALRHCQL NYCYVALPVK PHNLVRAVQG 70 80 90 100 110 120 FAAMGMRGFN ATIPHKENLL PLMHTLSEEA SHIGAVNTVV IDDDGKMTGH NTDAYGFITG 130 140 150 160 170 180 LKEAWRSDLS GLTAIMLGSG GAARAILYGL IQAKAARVII ANRTIERAQA LIEAMQPYAP 190 200 210 220 230 240 NTQLMVAPTQ ADQLPLESCD LLINTTSMGL KGETIPYIDL ARLPHHAFVS DIVYGAHPTP 250 260 270 280 LLRATAQHQL GGQDGLPMLI HQGAKAFELW TGHSMPVELV EHTLRQ

References

[1]

"Complete sequence of Magnetococcus sp. MC-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Goodwin L.A., Brettin T., Bruce D., Han C., Tapia R., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000471 Genomic DNA. Translation: ABK42551.1.
RefSeq	YP_863957.1. NC_008576.1.
3D structure databases
ProteinModelPortal	A0L3K8.
ModBase	Search...
Protein-protein interaction databases
STRING	A0L3K8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4480708.
GenomeReviews	Gene locus Mmc1_0022 in contig CP000471_GR.
KEGG	mgm:Mmc1_0022.
NMPDR	fig|156889.1.peg.3687.
PATRIC	22426500. VBIMagSp23654_0022.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	EHMELDE.
PhylomeDB	A0L3K8.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_MAGSM

Accession

Primary (citable) accession number: A0L3K8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program