A0L1S2 (SLMA_SHESA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoid occlusion factor SlmA

Gene names

Name:	slmA
Ordered Locus Names:	Shewana3_3773

Organism

Shewanella sp. (strain ANA-3) [Complete proteome] [HAMAP]

Taxonomic identifier

94122 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions By similarity. HAMAP-Rule MF_01839
Subunit structure	Homodimer By similarity. Interacts with FtsZ By similarity.
Subcellular location	Cytoplasm › nucleoid By similarity.
Sequence similarities	Belongs to the nucleoid occlusion factor SlmA family. Contains 1 HTH tetR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cytoplasm
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of barrier septum assembly Inferred from electronic annotation. Source: InterPro
Cellular_component	bacterial nucleoid Inferred from electronic annotation. Source: HAMAP cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	Nucleoid occlusion factor SlmA HAMAP-Rule MF_01839		PRO_1000070531
Regions
	Domain	7 – 67	61	HTH tetR-type
	DNA binding	30 – 49	20	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0L1S2 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: FB1A71C69B72D5EE	FASTA	197	22,703
	10 20 30 40 50 60 MAVSPKINRR EHILQCLAQM LETSPGQRIT TAKLASEVGV SEAALYRHFP SKARMFEGLI 70 80 90 100 110 120 EFIEESLLSR INIIMNDEKD TMRRCQLVLQ LLLIFAERNP GISRVLNGDA LLGENERLRS 130 140 150 160 170 180 RISTLFAKIE TQLKQILREK TLREGKGFNL DEAILANLLL AFAEGRIAQF VRSEFKLKPT 190 QHFDEQWRFI QHQLLQS

References

[1]

"Complete sequence of chromosome 1 of Shewanella sp. ANA-3." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Newman D., Salticov C., Konstantinidis K., Klappenback J., Tiedje J., Richardson P. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ANA-3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000469 Genomic DNA. Translation: ABK49991.1.
RefSeq	YP_871397.1. NC_008577.1.
3D structure databases
ProteinModelPortal	A0L1S2.
ModBase	Search...
Protein-protein interaction databases
STRING	94122.Shewana3_3773.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK49991; ABK49991; Shewana3_3773.
GeneID	4479983.
KEGG	shn:Shewana3_3773.
PATRIC	23575590. VBISheSp134792_4150.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1309.
HOGENOM	HOG000266053.
KO	K05501.
OMA	GERRVQI.
ProtClustDB	PRK09480.
Family and domain databases
Gene3D	1.10.357.10. 1 hit.
HAMAP	MF_01839. NO_factor_SlmA.
InterPro	IPR009057. Homeodomain-like. IPR001647. HTH_TetR. IPR023769. NO_SlmA. IPR015893. Tet_transcr_reg_TetR-like_C. IPR011075. Tet_transcr_reg_TetR-rel_C. [Graphical view]
Pfam	PF00440. TetR_N. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit. SSF48498. TetR_like_C. 1 hit.
PROSITE	PS01081. HTH_TETR_1. False negative. PS50977. HTH_TETR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SLMA_SHESA

Accession

Primary (citable) accession number: A0L1S2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	December 12, 2006
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program