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Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Shewanella sp. (strain ANA-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi15 – 151Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi18 – 181Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi94 – 941Iron-sulfur (4Fe-4S)UniRule annotation
Binding sitei219 – 2191S-adenosyl-L-methionineUniRule annotation
Binding sitei248 – 2481S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei269 – 2691S-adenosyl-L-methionineUniRule annotation
Binding sitei316 – 3161S-adenosyl-L-methionineUniRule annotation
Active sitei343 – 3431NucleophileUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSSP94122:GJ9K-3423-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
Synonyms:rumB
Ordered Locus Names:Shewana3_3309
OrganismiShewanella sp. (strain ANA-3)
Taxonomic identifieri94122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002589 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 38438423S rRNA (uracil(747)-C(5))-methyltransferase RlmCPRO_0000282014Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi94122.Shewana3_3309.

Structurei

3D structure databases

ProteinModelPortaliA0L0G4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107SFS. Bacteria.
COG2265. LUCA.
HOGENOMiHOG000218547.
KOiK03212.
OMAiNIQPIHM.
OrthoDBiPOG091H00VG.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01012. 23SrRNA_methyltr_RlmC. 1 hit.
InterProiIPR011825. 23SrRNA_MeTrfase_RlmC.
IPR030390. MeTrfase_TrmA_AS.
IPR030391. MeTrfase_TrmA_CS.
IPR029063. SAM-dependent_MTases.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0L0G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLVQCGYF ERGQCQSCRH IKLPMAQQLA AKNLELQQLL APFVDKTEPQ
60 70 80 90 100
FLPPVVGDSS GFRNKAKMVA LGAAHAPVLG IVSPSGEAVS LCDCLLYPTD
110 120 130 140 150
MQALLHRLER FVQQAGIPPY RVDKAKGELK FILLTRSQVR GEYMLRFVLR
160 170 180 190 200
SRDAIARIER ELPTLMAEYP QIKVVSVNLQ PVHMAILEGE EEIFLTENTR
210 220 230 240 250
LEERFNDVPL FIRPKSFFQT NPQVAAKLYQ TAREWVADFA PASLWDLFCG
260 270 280 290 300
VGGFGLHCAA KDIPLTGIEI EAEAIACAKM SAQLMGLDKV EFMALDSTDF
310 320 330 340 350
AKGEAAQTKP ELIIVNPPRR GIGESLCHSL SEFAPKAILY SSCNPKTLAK
360 370 380
DLGHIRGYRL TKVQLFDLFP HSDHFEVLAL LVKD
Length:384
Mass (Da):42,758
Last modified:December 12, 2006 - v1
Checksum:i33D819ED4A95DBD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000469 Genomic DNA. Translation: ABK49533.1.
RefSeqiWP_011718114.1. NC_008577.1.

Genome annotation databases

EnsemblBacteriaiABK49533; ABK49533; Shewana3_3309.
KEGGishn:Shewana3_3309.
PATRICi23574604. VBISheSp134792_3668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000469 Genomic DNA. Translation: ABK49533.1.
RefSeqiWP_011718114.1. NC_008577.1.

3D structure databases

ProteinModelPortaliA0L0G4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi94122.Shewana3_3309.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK49533; ABK49533; Shewana3_3309.
KEGGishn:Shewana3_3309.
PATRICi23574604. VBISheSp134792_3668.

Phylogenomic databases

eggNOGiENOG4107SFS. Bacteria.
COG2265. LUCA.
HOGENOMiHOG000218547.
KOiK03212.
OMAiNIQPIHM.
OrthoDBiPOG091H00VG.

Enzyme and pathway databases

BioCyciSSP94122:GJ9K-3423-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01012. 23SrRNA_methyltr_RlmC. 1 hit.
InterProiIPR011825. 23SrRNA_MeTrfase_RlmC.
IPR030390. MeTrfase_TrmA_AS.
IPR030391. MeTrfase_TrmA_CS.
IPR029063. SAM-dependent_MTases.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRLMC_SHESA
AccessioniPrimary (citable) accession number: A0L0G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 12, 2006
Last modified: September 7, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.