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A0KXK3

- NAGZ_SHESA

UniProt

A0KXK3 - NAGZ_SHESA

Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Shewanella sp. (strain ANA-3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei61 – 611SubstrateUniRule annotation
    Binding sitei69 – 691SubstrateUniRule annotation
    Binding sitei134 – 1341SubstrateUniRule annotation
    Sitei175 – 1751Important for catalytic activityUniRule annotation
    Active sitei177 – 1771Proton donor/acceptorUniRule annotation
    Active sitei249 – 2491NucleophileUniRule annotation

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cell cycle Source: UniProtKB-KW
    3. cell division Source: UniProtKB-KW
    4. peptidoglycan biosynthetic process Source: UniProtKB-KW
    5. peptidoglycan turnover Source: UniProtKB-HAMAP
    6. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSSP94122:GJ9K-2386-MONOMER.
    UniPathwayiUPA00544.

    Protein family/group databases

    CAZyiGH3. Glycoside Hydrolase Family 3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
    Alternative name(s):
    Beta-N-acetylhexosaminidaseUniRule annotation
    N-acetyl-beta-glucosaminidaseUniRule annotation
    Gene namesi
    Name:nagZUniRule annotation
    Ordered Locus Names:Shewana3_2293
    OrganismiShewanella sp. (strain ANA-3)
    Taxonomic identifieri94122 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002589: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Beta-hexosaminidasePRO_1000005662Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi94122.Shewana3_2293.

    Structurei

    3D structure databases

    ProteinModelPortaliA0KXK3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni164 – 1652Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000248526.
    KOiK01207.
    OMAiLLNGFVW.
    OrthoDBiEOG6BCT06.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    HAMAPiMF_00364. NagZ.
    InterProiIPR022956. Beta_hexosaminidase_bac.
    IPR019800. Glyco_hydro_3_AS.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00933. Glyco_hydro_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0KXK3-1 [UniParc]FASTAAdd to Basket

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    MSYLMLDLLS LDVSEAEAEM LRHPQVGGLI LFSRNFSSRE QLIALVQQIR    50
    QIRPEILIAV DHEGGRVQRF REGFTLIPAM GDILPAAKGD MVIAKRWACE 100
    LGFLMAIELL ACDIDLSFAP VLDLNGISQV IGKRSFSAKP EEVIALAQSF 150
    IEGMAEAGMG AVGKHFPGHG SVAADSHIAQ PIDEREAEAI FNQDILPFKD 200
    LIAMGKLSGI MPAHVIYPKV DPNPAGFSSY WLKQILRKEL GFNGVIFSDD 250
    LGMKGASIAG DYLGRAQAAL DAGCDMILVC NDNPGVMSLL NGFVWPASAP 300
    QHPASLLKPN AAQTAIALEN ASRWENAKQL AEQIQLAQQA KV 342
    Length:342
    Mass (Da):36,985
    Last modified:December 12, 2006 - v1
    Checksum:i0B1837F600E85098
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000469 Genomic DNA. Translation: ABK48522.1.
    RefSeqiWP_011717228.1. NC_008577.1.
    YP_869928.1. NC_008577.1.

    Genome annotation databases

    EnsemblBacteriaiABK48522; ABK48522; Shewana3_2293.
    GeneIDi4478050.
    KEGGishn:Shewana3_2293.
    PATRICi23572455. VBISheSp134792_2614.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000469 Genomic DNA. Translation: ABK48522.1 .
    RefSeqi WP_011717228.1. NC_008577.1.
    YP_869928.1. NC_008577.1.

    3D structure databases

    ProteinModelPortali A0KXK3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 94122.Shewana3_2293.

    Protein family/group databases

    CAZyi GH3. Glycoside Hydrolase Family 3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK48522 ; ABK48522 ; Shewana3_2293 .
    GeneIDi 4478050.
    KEGGi shn:Shewana3_2293.
    PATRICi 23572455. VBISheSp134792_2614.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000248526.
    KOi K01207.
    OMAi LLNGFVW.
    OrthoDBi EOG6BCT06.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .
    BioCyci SSP94122:GJ9K-2386-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    HAMAPi MF_00364. NagZ.
    InterProi IPR022956. Beta_hexosaminidase_bac.
    IPR019800. Glyco_hydro_3_AS.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00933. Glyco_hydro_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ANA-3.

    Entry informationi

    Entry nameiNAGZ_SHESA
    AccessioniPrimary (citable) accession number: A0KXK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3