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A0KVZ2 (ASTB_SHESA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-succinylarginine dihydrolase
EC=3.5.3.23
Gene names
Name:astB
Ordered Locus Names:Shewana3_1728
OrganismShewanella sp. (strain ANA-3) [Complete proteome] [HAMAP]
Taxonomic identifier94122 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO2 By similarity. HAMAP MF_01172

Catalytic activity

N(2)-succinyl-L-arginine + 2 H2O = N(2)-succinyl-L-ornithine + 2 NH3 + CO2. HAMAP MF_01172

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 2/5. HAMAP MF_01172

Subunit structure

Homodimer By similarity. HAMAP MF_01172

Sequence similarities

Belongs to the succinylarginine dihydrolase family.

Ontologies

Keywords
   Biological processArginine metabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionN-succinylarginine dihydrolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444N-succinylarginine dihydrolase HAMAP MF_01172
PRO_1000065740

Regions

Region19 – 2810Substrate binding By similarity
Region137 – 1382Substrate binding By similarity

Sites

Active site1741 By similarity
Active site2501 By similarity
Active site3681Nucleophile By similarity
Binding site1101Substrate By similarity
Binding site2141Substrate By similarity
Binding site2521Substrate By similarity
Binding site3621Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A0KVZ2 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 177FE5A4F50AA203

FASTA44449,067
        10         20         30         40         50         60 
MKHFEANFDG LVGPTHNYAG LSFGNVASLN NAALVSNPKA AAKQGLQKAK ALADLGMIQG 

        70         80         90        100        110        120 
MLAPQERPDL NTLRRIGFSG SDAQVLQQAA KTAPALLNAC CSASSMWTAN AATVSPSADT 

       130        140        150        160        170        180 
RDGKLHFTPA NLVDKLHRSI EPTTTGRILT ATFNDPHYFH HHNHLPEHNS FGDEGAANHT 

       190        200        210        220        230        240 
RLCQEYGHAG VELFVYGQEA TNPNAPRPQK YPARQTLEAS MAIARLHQLE EDNCVFIQQN 

       250        260        270        280        290        300 
PDVIDQGVFH NDVIAVGNQN VLFYHEQAFL NTQAKLDEIR RKLDTELFFI EVPTTKVAIN 

       310        320        330        340        350        360 
NAVKSYLFNT QIITLPSGEM AIIAPTDCQE NPAVYAYLNE LLTLNTPIKQ VLYFDVKQSM 

       370        380        390        400        410        420 
QNGGGPACLR LRVAMNEREV AAANQHTLLN DALFARLNTW VDKHYRDRLS TQDLADPQLV 

       430        440 
VESRTALDEL TQIMKLGSVY PFQR

« Hide

References

[1]"Complete sequence of chromosome 1 of Shewanella sp. ANA-3."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Newman D., Salticov C., Konstantinidis K., Klappenback J., Tiedje J., Richardson P.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ANA-3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000469 Genomic DNA. Translation: ABK47961.1.
RefSeqYP_869367.1. NC_008577.1.

3D structure databases

ProteinModelPortalA0KVZ2.
SMRA0KVZ2. Positions 3-444.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0KVZ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4479561.
GenomeReviewsGene locus Shewana3_1728 in contig CP000469_GR.
KEGGshn:Shewana3_1728.
NMPDRfig|94122.5.peg.1807.
PATRIC23571230. VBISheSp134792_2018.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3724.
HOGENOMHBG289862.
OMAHFAHHPA.
PhylomeDBA0KVZ2.
ProtClustDBPRK13281.

Enzyme and pathway databases

BioCycSSP94122:SHEWANA3_1728-MONOMER.

Family and domain databases

HAMAPMF_01172. AstB.
[Tree]
InterProIPR007079. SuccinylArg_d-Hdrlase_AstB.
[Graphical view]
Gene3DG3DSA:3.75.10.20. SuccinylArg_di_hydro. 1 hit.
KOK01484.
PfamPF04996. AstB. 1 hit.
[Graphical view]
TIGRFAMsTIGR03241. Arg_catab_astB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASTB_SHESA
AccessionPrimary (citable) accession number: A0KVZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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