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A0KVN8 (SPEA_SHESA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:Shewana3_1624
OrganismShewanella sp. (strain ANA-3) [Complete proteome] [HAMAP]
Taxonomic identifier94122 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length637 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 637637Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000024271

Regions

Region286 – 29611Substrate-binding Potential

Amino acid modifications

Modified residue1011N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A0KVN8 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 6C9E74595237D74E

FASTA63771,019
        10         20         30         40         50         60 
MNDWSIDAAR AGYNVTHWSQ GFYGISDQGE VTVSPDPKNP DHKIGLNELA KDMVKAGVAL 

        70         80         90        100        110        120 
PVLVRFPQIL HHRVNSLCQA FDQAIQKYEY QADYLLVYPI KVNQQKTVVE EILASQASKE 

       130        140        150        160        170        180 
VPQLGLEAGS KPELMAVLAM AQKASSVIVC NGYKDNEYIR LALIGEKLGH KVYIVLEKLS 

       190        200        210        220        230        240 
ELKMVLAESK RLGVKPRLGL RARLAFQGKG KWQASGGEKS KFGLSAAQIL TVVDQLKQED 

       250        260        270        280        290        300 
MLDSLQLLHF HLGSQIANIR DIRQGVSEAA RFYCELRELG ASINCFDVGG GLAVDYDGTR 

       310        320        330        340        350        360 
SQSNNSMNYG LSEYANNIVN VLTDICNEYE QPMPRIISES GRHLTAHHAV LITDVIGTEA 

       370        380        390        400        410        420 
YQVEEIQPPA EESPQLLHNM WQSWTEISGR ADQRALIEIY HDSQSDLQEA QSLFALGQLS 

       430        440        450        460        470        480 
LAERAWAEQA NLRVCHEVQG LLSTKNRYHR PIIDELNEKL ADKFFVNFSL FQSLPDAWGI 

       490        500        510        520        530        540 
DQVFPVLPLS GLDKAPERRA VMLDITCDSD GIVDQYVDGQ GIETTLPVPA WSAESPYLMG 

       550        560        570        580        590        600 
FFMVGAYQEI LGDMHNLFGD TNSAVVSIEE NGMTNIESVL AGDTVADVLR YVNLDAVDFM 

       610        620        630 
RTYEELVNQH IAEEERAQIL EELQVGLKGY TYLEDFS 

« Hide

References

[1]"Complete sequence of chromosome 1 of Shewanella sp. ANA-3."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Newman D., Salticov C., Konstantinidis K., Klappenback J., Tiedje J., Richardson P.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ANA-3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000469 Genomic DNA. Translation: ABK47857.1.
RefSeqYP_869263.1. NC_008577.1.

3D structure databases

ProteinModelPortalA0KVN8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING94122.Shewana3_1624.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK47857; ABK47857; Shewana3_1624.
GeneID4476588.
KEGGshn:Shewana3_1624.
PATRIC23571020. VBISheSp134792_1913.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAIDHYVDG.
OrthoDBEOG676Z0R.

Enzyme and pathway databases

BioCycSSP94122:GJ9K-1702-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSPEA_SHESA
AccessionPrimary (citable) accession number: A0KVN8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways