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Protein

Anthranilate synthase component 1

Gene

Shewana3_1520

Organism
Shewanella sp. (strain ANA-3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (Shewana3_1520)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Multifunctional fusion protein (trpF)
  4. Multifunctional fusion protein (trpF)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59TryptophanUniRule annotation1
Metal bindingi392MagnesiumUniRule annotation1
Binding sitei480SubstrateUniRule annotation1
Binding sitei500SubstrateUniRule annotation1
Binding sitei516Substrate; via amide nitrogenUniRule annotation1
Metal bindingi529MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00035; UER00040

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate synthase component 1UniRule annotation (EC:4.1.3.27UniRule annotation)
Gene namesi
Ordered Locus Names:Shewana3_1520Imported
OrganismiShewanella sp. (strain ANA-3)Imported
Taxonomic identifieri94122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002589 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi94122.Shewana3_1520

Structurei

3D structure databases

ProteinModelPortaliA0KVD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 215Anth_synt_I_NInterPro annotationAdd BLAST177
Domaini273 – 533Chorismate_bindInterPro annotationAdd BLAST261

Sequence similaritiesi

Belongs to the anthranilate synthase component I family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CRQ Bacteria
COG0147 LUCA
HOGENOMiHOG000025144
KOiK01657
OMAiAYRSFMN
OrthoDBiPOG091H01VQ

Family and domain databases

Gene3Di3.60.120.10, 1 hit
InterProiView protein in InterPro
IPR005801 ADC_synthase
IPR019999 Anth_synth_I-like
IPR006805 Anth_synth_I_N
IPR005257 Anth_synth_I_TrpE
IPR015890 Chorismate_C
PANTHERiPTHR11236:SF22 PTHR11236:SF22, 1 hit
PfamiView protein in Pfam
PF04715 Anth_synt_I_N, 1 hit
PF00425 Chorismate_bind, 1 hit
PIRSFiPIRSF001373 TrpE, 1 hit
PRINTSiPR00095 ANTSNTHASEI
SUPFAMiSSF56322 SSF56322, 1 hit
TIGRFAMsiTIGR00565 trpE_proteo, 1 hit

Sequencei

Sequence statusi: Complete.

A0KVD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLKTFNQVT QVDGAHFAPS QQTFARSHTL KATLAYHSDP LRLYQHITQD
60 70 80 90 100
VPHTMLLESA EIDSKENLKS MVMTHAALMI RCDGYRLRFS ALSDNGVSLL
110 120 130 140 150
APIEQFFIAR SSQTQCQRDG HNLVVTLQKD TELKDEDARL KSTSPLDGLR
160 170 180 190 200
LFVKHIDCGQ TPAFEDLFLG GVLSYDLIDT VEPLPEAPNG ANDCPDYLFY
210 220 230 240 250
LAETLILIDH KQKHAEIITH NFSEGTEQHL EVTQALAERA ENISAQCEAL
260 270 280 290 300
AKSATPAPAL VGITATEQVN VSDDDFKQTV IDLKEHIIAG DIFQVVPSRS
310 320 330 340 350
FSLPCPDTLG AYRALRLTNP SPYMFYFRGY DFTLFGASPE SALKYEASNN
360 370 380 390 400
QVEVYPIAGT RKRGKTASGE IDFDLDSRIE LELRLDKKEL SEHLMLVDLA
410 420 430 440 450
RNDIARISQS GSRKVAELLK VDRYSHVMHL VSRVTGQLRQ DLDALHAYQA
460 470 480 490 500
CMNMGTLVGA PKVRASQLVR QAEKTRRGSY GGAVGYLNAL GDMDTCIVIR
510 520 530 540 550
SAFVKNGVAH IQAGAGVVFD SDPQSEADET RQKAQAVISA IKMGAGLDES
560
QQATATTTTE QQR
Length:563
Mass (Da):62,123
Last modified:December 12, 2006 - v1
Checksum:iBC7CE7DCA65F0890
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000469 Genomic DNA Translation: ABK47754.1
RefSeqiWP_011716573.1, NC_008577.1

Genome annotation databases

EnsemblBacteriaiABK47754; ABK47754; Shewana3_1520
KEGGishn:Shewana3_1520

Similar proteinsi

Entry informationi

Entry nameiA0KVD5_SHESA
AccessioniPrimary (citable) accession number: A0KVD5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: February 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health