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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Shewanella sp. (strain ANA-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (Shewana3_1520)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpF)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei88Anthranilate 1; via carbonyl oxygenUniRule annotation1
Binding sitei88Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei96PhosphoribosylpyrophosphateUniRule annotation1
Metal bindingi100Magnesium 1UniRule annotation1
Binding sitei119Anthranilate 1UniRule annotation1
Binding sitei128Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei174Anthranilate 2UniRule annotation1
Metal bindingi232Magnesium 2UniRule annotation1
Metal bindingi233Magnesium 1UniRule annotation1
Metal bindingi233Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:Shewana3_1518
OrganismiShewanella sp. (strain ANA-3)
Taxonomic identifieri94122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002589 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000430661 – 347Anthranilate phosphoribosyltransferaseAdd BLAST347

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi94122.Shewana3_1518

Structurei

3D structure databases

ProteinModelPortaliA0KVD3
SMRiA0KVD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni91 – 92Phosphoribosylpyrophosphate bindingUniRule annotation2
Regioni98 – 101Phosphoribosylpyrophosphate bindingUniRule annotation4
Regioni116 – 124Phosphoribosylpyrophosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108I0Q Bacteria
COG0547 LUCA
HOGENOMiHOG000230451
KOiK00766
OMAiLCALKIK
OrthoDBiPOG091H01QX

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
HAMAPiMF_00211 TrpD, 1 hit
InterProiView protein in InterPro
IPR005940 Anthranilate_Pribosyl_Tfrase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
TIGRFAMsiTIGR01245 trpD, 1 hit

Sequencei

Sequence statusi: Complete.

A0KVD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATSIQPLL DILFLGKALT REQTASLFST LIQGEMNEAV MAAMLMALKI
60 70 80 90 100
RGETIAEISG AADAMRAAAK PFPYPASSRS QGIIDIVGTG GDGFNTINIS
110 120 130 140 150
TTAAFVAAAA GAKVAKHGNR SVSSKSGSSD LLAQFGIDLT MSPELASRCL
160 170 180 190 200
ESLNLCFLFA PHYHGGVKHA VPVRQALKTR TLFNVLGPLI NPARPEFMLL
210 220 230 240 250
GVYSPELVTP IARVLQALGT QRAMVVHGSG LDEVALHGST QVAELKDGEI
260 270 280 290 300
IEYQLTPADF GVPQAQISEL EGGEPAQNAQ ITQSILQGQG SDAHTHAVAI
310 320 330 340
NAGCALYLCG LSDSVKAGTA LALNTIKSGK AFELLNQLAK VSSEAQE
Length:347
Mass (Da):36,225
Last modified:December 12, 2006 - v1
Checksum:iBE7A08DCC9697E06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000469 Genomic DNA Translation: ABK47752.1
RefSeqiWP_011716571.1, NC_008577.1

Genome annotation databases

EnsemblBacteriaiABK47752; ABK47752; Shewana3_1518
KEGGishn:Shewana3_1518

Similar proteinsi

Entry informationi

Entry nameiTRPD_SHESA
AccessioniPrimary (citable) accession number: A0KVD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: November 22, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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