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Protein
Submitted name:

Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase

Gene

Shewana3_1517

Organism
Shewanella sp. (strain ANA-3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.SAAS annotation

Pathway: L-tryptophan biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-tryptophan from chorismate.SAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (Shewana3_1520)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. no protein annotated in this organism
  4. Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (Shewana3_1517)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseSAAS annotation, IsomeraseImported, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisSAAS annotation

Enzyme and pathway databases

BioCyciSSP94122:GJ9K-1581-MONOMER.
UniPathwayiUPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Submitted name:
Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomeraseImported (EC:4.1.1.48Imported, EC:5.3.1.24Imported)
Gene namesi
Ordered Locus Names:Shewana3_1517Imported
OrganismiShewanella sp. (strain ANA-3)Imported
Taxonomic identifieri94122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002589 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi94122.Shewana3_1517.

Structurei

3D structure databases

ProteinModelPortaliA0KVD2.
SMRiA0KVD2. Positions 32-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0134.
HOGENOMiHOG000280458.
KOiK13498.
OMAiSFILECK.
OrthoDBiEOG6WT8JX.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
HAMAPiMF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0KVD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQVQQPDAH RSEDNQASQD VRGSMQTSTA KANVLTRIVD TKAAHIAALK
60 70 80 90 100
LRFPEDSLTP KISDRSLFAA LKAPKAGYIL ECKKASPSKG LIRKDFDVEA
110 120 130 140 150
IASIYTQYAA GISVLTDEQF FQGDIDYIPK VRAKVSQPIL CKDFFVDEYQ
160 170 180 190 200
VKLAAHQGAD AILLMLSVLE DERYQQLASE AAKYQLDVLT EVSNEEELKR
210 220 230 240 250
AIALNAPIIG INNRNLRDLS TDLATTEALA PHIGSDRVVI SESGIYTNEQ
260 270 280 290 300
VRRLSPLVDG FLVGSSIMAE EDIDLACRKL IFGHNKVCGL TRLEDIQAAA
310 320 330 340 350
TAGAVYAGLI FAEKSPRALT QEAAKQLVQQ YRAANLPAIE FVGVFVNSTP
360 370 380 390 400
ELMASVAQEC SLAALQLHGS ETELEIAELS QLLQQAGLNT QIWKAVSVDA
410 420 430 440 450
QSGELAAMPR GVQRYLFDSK NDAGFGGTGQ AFNWQLPIAH KAEAMLAGGL
460 470 480 490
NADNAARANA QGFYGLDFNS GLETAPGVKS AEKIQAAFSQ LRL
Length:493
Mass (Da):53,347
Last modified:December 12, 2006 - v1
Checksum:i70EEF2789494009F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000469 Genomic DNA. Translation: ABK47751.1.
RefSeqiWP_011716570.1. NC_008577.1.
YP_869157.1. NC_008577.1.

Genome annotation databases

EnsemblBacteriaiABK47751; ABK47751; Shewana3_1517.
KEGGishn:Shewana3_1517.
PATRICi23570756. VBISheSp134792_1795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000469 Genomic DNA. Translation: ABK47751.1.
RefSeqiWP_011716570.1. NC_008577.1.
YP_869157.1. NC_008577.1.

3D structure databases

ProteinModelPortaliA0KVD2.
SMRiA0KVD2. Positions 32-287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi94122.Shewana3_1517.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK47751; ABK47751; Shewana3_1517.
KEGGishn:Shewana3_1517.
PATRICi23570756. VBISheSp134792_1795.

Phylogenomic databases

eggNOGiCOG0134.
HOGENOMiHOG000280458.
KOiK13498.
OMAiSFILECK.
OrthoDBiEOG6WT8JX.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00043.
BioCyciSSP94122:GJ9K-1581-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
HAMAPiMF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ANA-3Imported.

Entry informationi

Entry nameiA0KVD2_SHESA
AccessioniPrimary (citable) accession number: A0KVD2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: June 24, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.