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Protein
Submitted name:

Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase

Gene

trpF

Organism
Shewanella sp. (strain ANA-3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotationSAAS annotation
N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 and 4 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (Shewana3_1520)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpF)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotationSAAS annotation, IsomeraseUniRule annotationImported, Lyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042
UPA00035; UER00043

Names & Taxonomyi

Protein namesi
Submitted name:
Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomeraseImported (EC:4.1.1.48Imported, EC:5.3.1.24Imported)
Gene namesi
Name:trpFUniRule annotation
Synonyms:trpCUniRule annotation
Ordered Locus Names:Shewana3_1517Imported
OrganismiShewanella sp. (strain ANA-3)Imported
Taxonomic identifieri94122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002589 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi94122.Shewana3_1517

Structurei

3D structure databases

ProteinModelPortaliA0KVD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 280IGPSInterPro annotationAdd BLAST246
Domaini285 – 489PRAIInterPro annotationAdd BLAST205

Sequence similaritiesi

Belongs to the TrpC family.UniRule annotation
Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DK0 Bacteria
COG0134 LUCA
COG0135 LUCA
HOGENOMiHOG000280458
KOiK13498
OMAiYDIIGIN
OrthoDBiPOG091H02GI

Family and domain databases

CDDicd00331 IGPS, 1 hit
cd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 2 hits
HAMAPiMF_00134_B IGPS_B, 1 hit
MF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR013798 Indole-3-glycerol_P_synth
IPR001468 Indole-3-GlycerolPSynthase_CS
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00218 IGPS, 1 hit
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 2 hits
PROSITEiView protein in PROSITE
PS00614 IGPS, 1 hit

Sequencei

Sequence statusi: Complete.

A0KVD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQVQQPDAH RSEDNQASQD VRGSMQTSTA KANVLTRIVD TKAAHIAALK
60 70 80 90 100
LRFPEDSLTP KISDRSLFAA LKAPKAGYIL ECKKASPSKG LIRKDFDVEA
110 120 130 140 150
IASIYTQYAA GISVLTDEQF FQGDIDYIPK VRAKVSQPIL CKDFFVDEYQ
160 170 180 190 200
VKLAAHQGAD AILLMLSVLE DERYQQLASE AAKYQLDVLT EVSNEEELKR
210 220 230 240 250
AIALNAPIIG INNRNLRDLS TDLATTEALA PHIGSDRVVI SESGIYTNEQ
260 270 280 290 300
VRRLSPLVDG FLVGSSIMAE EDIDLACRKL IFGHNKVCGL TRLEDIQAAA
310 320 330 340 350
TAGAVYAGLI FAEKSPRALT QEAAKQLVQQ YRAANLPAIE FVGVFVNSTP
360 370 380 390 400
ELMASVAQEC SLAALQLHGS ETELEIAELS QLLQQAGLNT QIWKAVSVDA
410 420 430 440 450
QSGELAAMPR GVQRYLFDSK NDAGFGGTGQ AFNWQLPIAH KAEAMLAGGL
460 470 480 490
NADNAARANA QGFYGLDFNS GLETAPGVKS AEKIQAAFSQ LRL
Length:493
Mass (Da):53,347
Last modified:December 12, 2006 - v1
Checksum:i70EEF2789494009F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000469 Genomic DNA Translation: ABK47751.1

Genome annotation databases

EnsemblBacteriaiABK47751; ABK47751; Shewana3_1517
KEGGishn:Shewana3_1517

Similar proteinsi

Entry informationi

Entry nameiA0KVD2_SHESA
AccessioniPrimary (citable) accession number: A0KVD2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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