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Protein

Glycosyl hydrolase family 109 protein 1

Gene

Shewana3_1428

Organism
Shewanella sp. (strain ANA-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Glycosidase.By similarity

Cofactori

NAD(+)By similarityNote: Binds 1 NAD(+) per subunit. The NAD(+) cannot dissociate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861NADBy similarity
Binding sitei184 – 1841NADBy similarity
Binding sitei213 – 2131SubstrateBy similarity
Binding sitei232 – 2321SubstrateBy similarity
Binding sitei244 – 2441NADBy similarity
Binding sitei326 – 3261SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 652NADBy similarity
Nucleotide bindingi135 – 1384NADBy similarity
Nucleotide bindingi155 – 1562NADBy similarity

GO - Molecular functioni

  1. hydrolase activity, acting on glycosyl bonds Source: UniProtKB-KW
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSSP94122:GJ9K-1492-MONOMER.

Protein family/group databases

CAZyiGH109. Glycoside Hydrolase Family 109.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosyl hydrolase family 109 protein 1 (EC:3.2.1.-)
Gene namesi
Ordered Locus Names:Shewana3_1428
OrganismiShewanella sp. (strain ANA-3)
Taxonomic identifieri94122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002589 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Tat-type signalPROSITE-ProRule annotationAdd
BLAST
Chaini32 – 459428Glycosyl hydrolase family 109 protein 1PRO_0000348563Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Interactioni

Protein-protein interaction databases

STRINGi94122.Shewana3_1428.

Structurei

3D structure databases

ProteinModelPortaliA0KV43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni244 – 2474Substrate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0673.
HOGENOMiHOG000252553.
OMAiMESGKHA.
OrthoDBiEOG61P6MK.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF10518. TAT_signal. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0KV43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNIHRRHFL KAAGAVTAGL VTANIALNAN ASSVAPKPRV GKSVIGLIAP
60 70 80 90 100
KMELVRVGFI GVGERGFSHV EQFCHLEGVE LKAICDTHQA VIDRAVEHIV
110 120 130 140 150
KQNRPKPAVY TGNDLSYREL LNRDDIDIVI ISTPWEWHAP MAIDTMESGK
160 170 180 190 200
HAFVEVPLAL TVEECWQLVD TAERTQKNCM MMENVNYGRE ELMVLNMVRQ
210 220 230 240 250
GVFGELLHGE AAYIHELRWQ MKEIDHKTGS WRTYWHTKRN GNLYPTHGLG
260 270 280 290 300
PISQYMNINR GDRFDYLTSM SSPALGRALY AKREFPADHE RNQLKYINGD
310 320 330 340 350
MSTSLIKTVK GRTIMVQHDT TTPRPYSRHN LIQGTNGVFA GFPNRIAVEH
360 370 380 390 400
GGFGKSYHEW DMDMQKWYDK YDHPLWQRIG KEAEINGGHG GMDFVMLWRM
410 420 430 440 450
VYCLRNGEAL DQDVYDGAAW SVVNILSEQS LNNRSNSVNF PDFTRGAWEH

ATPLGIVGA
Length:459
Mass (Da):52,027
Last modified:December 11, 2006 - v1
Checksum:i360BB310F4E3318D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000469 Genomic DNA. Translation: ABK47662.1.
RefSeqiWP_011716495.1. NC_008577.1.
YP_869068.1. NC_008577.1.

Genome annotation databases

EnsemblBacteriaiABK47662; ABK47662; Shewana3_1428.
KEGGishn:Shewana3_1428.
PATRICi23570570. VBISheSp134792_1702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000469 Genomic DNA. Translation: ABK47662.1.
RefSeqiWP_011716495.1. NC_008577.1.
YP_869068.1. NC_008577.1.

3D structure databases

ProteinModelPortaliA0KV43.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi94122.Shewana3_1428.

Protein family/group databases

CAZyiGH109. Glycoside Hydrolase Family 109.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK47662; ABK47662; Shewana3_1428.
KEGGishn:Shewana3_1428.
PATRICi23570570. VBISheSp134792_1702.

Phylogenomic databases

eggNOGiCOG0673.
HOGENOMiHOG000252553.
OMAiMESGKHA.
OrthoDBiEOG61P6MK.

Enzyme and pathway databases

BioCyciSSP94122:GJ9K-1492-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF10518. TAT_signal. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ANA-3.

Entry informationi

Entry nameiG1091_SHESA
AccessioniPrimary (citable) accession number: A0KV43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2008
Last sequence update: December 11, 2006
Last modified: March 31, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.