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A0KSX7 (NRFA_SHESA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c-552
EC=1.7.2.2
Alternative name(s):
Ammonia-forming cytochrome c nitrite reductase
Short name=Cytochrome c nitrite reductase
Gene names
Name:nrfA
Ordered Locus Names:Shewana3_0658
OrganismShewanella sp. (strain ANA-3) [Complete proteome] [HAMAP]
Taxonomic identifier94122 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in nitrite reduction By similarity. HAMAP MF_01182

Catalytic activity

NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+. HAMAP MF_01182

Cofactor

Binds 1 calcium ion per monomer By similarity. HAMAP MF_01182

Binds 5 heme groups covalently per monomer By similarity.

Pathway

Nitrogen metabolism; nitrate reduction (assimilation). HAMAP MF_01182

Subcellular location

Periplasm By similarity HAMAP MF_01182.

Sequence similarities

Belongs to the cytochrome c-552 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 473440Cytochrome c-552 HAMAP MF_01182
PRO_1000138223

Sites

Metal binding931Iron (heme 3 axial ligand) By similarity
Metal binding1251Iron (heme 1 axial ligand) By similarity
Metal binding1631Iron (heme 2 axial ligand) By similarity
Metal binding2051Iron (heme 3 axial ligand) By similarity
Metal binding2071Calcium By similarity
Metal binding2081Calcium; via carbonyl oxygen By similarity
Metal binding2561Calcium; via carbonyl oxygen By similarity
Metal binding2581Calcium By similarity
Metal binding2701Iron (heme 5 axial ligand) By similarity
Metal binding2811Iron (heme 4 axial ligand) By similarity
Metal binding2961Iron (heme 2 axial ligand) By similarity
Metal binding3131Iron (heme 5 axial ligand) By similarity
Metal binding3881Iron (heme 4 axial ligand) By similarity
Binding site1211Heme 1 (covalent) By similarity
Binding site1241Heme 1 (covalent) By similarity
Binding site1591Heme 2 (covalent) By similarity
Binding site1621Heme 2 (covalent) By similarity
Binding site2011Heme 3 (covalent) By similarity
Binding site2041Heme 3 (covalent) By similarity
Binding site2081Substrate By similarity
Binding site2591Substrate By similarity
Binding site2771Heme 4 (covalent) By similarity
Binding site2801Heme 4 (covalent) By similarity
Binding site3091Heme 5 (covalent) By similarity
Binding site3121Heme 5 (covalent) By similarity

Sequences

Sequence LengthMass (Da)Tools
A0KSX7 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 46CA9B7417F288A4

FASTA47352,673
        10         20         30         40         50         60 
MQHGDEMMKK MTGKSFALSA LVAASFMAAG AMASDKTEPR NEVYKDKFAN QYNSWHDTAK 

        70         80         90        100        110        120 
SEEITDALAG DPSLVILWAG YGFAKDYNAP RGHMYAVTDV RNTLRTGAPA NAEDGPMPMA 

       130        140        150        160        170        180 
CWSCKSPDVP RLIEEQGEEG YFKGKWAKGG PEVVNTIGCS DCHEKGTPKL RISRPFAERA 

       190        200        210        220        230        240 
METIGTPFDK ASKKDKQSMV CGQCHVEYYF EKKDDRKGFV KFPWDSGTTV EQMEAYYDAI 

       250        260        270        280        290        300 
EFSDWTHALS KTPMLKAQHP GYETWKLGVH GKNDVSCVDC HMPKVTNDKG RKYTDHKVGN 

       310        320        330        340        350        360 
PFDRFDETCA TCHSQSKEFL EGITKERYAK VKELKARAEG QLVKAHFEAA KAWEVGATEA 

       370        380        390        400        410        420 
EMKPILTDIR HAQWRWDFAI ASHGVAAHAP EEALRILGTA VDKAADARVK LAQLLAKKGV 

       430        440        450        460        470 
TDAVAIPDIS TKAKAQAALG MDMDKMNAEK EAFKKDVLPK WDEEAKKREA TYK

« Hide

References

[1]"Complete sequence of chromosome 1 of Shewanella sp. ANA-3."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Newman D., Salticov C., Konstantinidis K., Klappenback J., Tiedje J., Richardson P.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ANA-3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000469 Genomic DNA. Translation: ABK46896.1.
RefSeqYP_868302.1. NC_008577.1.

3D structure databases

ProteinModelPortalA0KSX7.
SMRA0KSX7. Positions 38-467.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0KSX7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4476868.
GenomeReviewsGene locus Shewana3_0658 in contig CP000469_GR.
KEGGshn:Shewana3_0658.
NMPDRfig|94122.5.peg.798.
PATRIC23568914. VBISheSp134792_0913.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3303.
HOGENOMHBG488281.
OMARDINSAC.
PhylomeDBA0KSX7.
ProtClustDBPRK11125.

Enzyme and pathway databases

BioCycSSP94122:SHEWANA3_0658-MONOMER.

Family and domain databases

HAMAPMF_01182. Cytochrom_C552.
[Tree]
InterProIPR003321. Cyt_c552.
IPR017570. Cyt_c_NO2Rdtase_formate-dep.
IPR011031. Multihaem_cyt.
[Graphical view]
KOK03385.
PfamPF02335. Cytochrom_C552. 1 hit.
[Graphical view]
PIRSFPIRSF000243. Cyt_c552. 1 hit.
TIGRFAMsTIGR03152. Cyto_c552_HCOOH. 1 hit.
PROSITEPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNRFA_SHESA
AccessionPrimary (citable) accession number: A0KSX7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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